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Brett Andrew McCray, M.D., Ph.D.

Brett Andrew McCray, M.D., Ph.D.

Headshot of Brett Andrew McCray
  • Co-director of the Johns Hopkins Charcot-Marie-Tooth Disease Clinic
  • Assistant Professor of Neurology

Expertise

Charcot Marie Tooth Disease (CMT), Hereditary Neuropathy, Peripheral Neuropathy ...read more

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Insurance Information

Main Phone

Outside of Maryland & Washington D.C.

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Locations

Johns Hopkins Outpatient Center

Appointment Phone: 410-614-1196
601 N. Caroline St.
Baltimore, MD 21287 map
Fax: 410-502-5459

Background

Dr. Brett McCray is an assistant professor in neurology whose clinical and research interest is furthering the understanding and treatment of peripheral neuropathy, particularly inherited forms of peripheral neuropathy such as Charcot-Marie-Tooth (CMT) disease. He serves as the co-director of the Johns Hopkins CMT Clinic and the Johns Hopkins site principal investigator for the Inherited Neuropathies Consortium (INC) natural history studies. He is particularly focused on inherited neuropathy due to mutations in TRPV4 (transient receptor potential vanilloid 4) that cause a range of conditions including CMT type 2C, scapuloperoneal spinal muscular atrophy, and congenital distal spinal muscular atrophy.

Dr. McCray's laboratory research uses a combined strategy of analyzing cultured cells, primary neurons, mouse models, and Drosophila models to elucidate pathways important in the pathogenesis of TRPV4 neuropathy and other forms of neuropathy.

Working with the INC and Dr. Charlotte Sumner at Johns Hopkins, Dr. McCray has established a TRPV4 neuropathy patient database to gain more knowledge about the natural history of TRPV4 neuropathy, learn more about the range of associated symptoms, and to determine if there are ways to detect and measure disease over time. He has also established a TRPV4 Channelopathies Clinic at Johns Hopkins to learn more about this condition. The overall goal of these efforts is to move towards a clinical trial in TRPV4 neuropathy.

If you are interested in learning more about the Johns Hopkins CMT Center, the TRPV4 patient registry, or the Johns Hopkins TRPV4 Channelopathies Clinic, please call 410-614-1196.

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Titles

  • Co-director of the Johns Hopkins Charcot-Marie-Tooth Disease Clinic
  • Director of the Johns Hopkins TRPV4 Channelopathies Clinic
  • Assistant Professor of Neurology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; University of Pennsylvania School of Medicine (2011)

Residencies

  • Neurology; Brigham and Women's Hospital (2015)

Fellowships

  • Neuromuscular Medicine; Johns Hopkins University School of Medicine (2016)

Board Certifications

  • American Board of Psychiatry And Neurology (Neurology) (2015)

Research & Publications

Selected Publications

McCray BA, Diehl E, Sullivan JM, Aisenberg WH, Zaccor NW, Lau AR, Rich DJ, Goretzki B, Hellmich UA, Lloyd TE, Sumner CJ. Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension. Nat Commun. 2021 Mar 4;12(1):1444. PubMed Central PMCID: PMC7933254.

Woolums BM, McCray BA, Sung H, Tabuchi M, Sullivan JM, Ruppell KT, Yang Y, Mamah C, Aisenberg WH, Saavedra-Rivera PC, Larin BS, Lau AR, Robinson DN, Xiang Y, Wu MN, Sumner CJ, Lloyd TE. TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2. Nat Commun. 2020 May 29;11(1):2679. PubMed Central PMCID: PMC7260201.

McCray BA, Schindler A, Hoover-Fong JE, Sumner CJ. cmt2c. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Mirzaa G, Amemiya A, editors. Autosomal Dominant TRPV4 Disorders [Internet] Seattle (WA): University of Washington, Seattle; 1993.

Activities & Honors

Honors

  • Wolfe Neuropathy Research Prize, American Neurological Association, 2021
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