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Brett Andrew McCray, M.D., Ph.D.

Headshot of Brett Andrew McCray
  • Assistant Professor of Neurology
Male

Expertise

Charcot Marie Tooth Disease (CMT)

Background

Dr. Brett McCray is an assistant professor in neurology whose research interest is furthering understanding of the molecular pathogenesis of Charcot-Marie-Tooth disease and other inherited forms of axonal neuropathy. The goals of his research are to identify common pathways that are disrupted across various forms of Charcot-Marie-Tooth disease and to identify therapeutic targets that can ultimately lead to the development of treatments. His current studies focus on how mutations in the cation channel TRPV4 and the mitochondrial protein mitofusin2 (MFN2) lead to axonal forms of Charcot-Marie-Tooth disease. Dr. McCray's research uses a combined strategy of analyzing cultured cells, primary neurons, mouse models, and Drosophila models to elucidate pathways important in the pathogenesis of neuropathy. His earlier studies explored the axonal trafficking protein Rab7 lead to a subtype of Charcot-Marie-Tooth disease. 

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Titles

  • Assistant Professor of Neurology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; University of Pennsylvania School of Medicine (2011)

Residencies

  • Neurology; Brigham and Women's Hospital (2015)

Fellowships

  • Neuromuscular Medicine; Johns Hopkins University School of Medicine (2016)

Patient Ratings & Comments

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