Research Summary
We study airway neural control. We have characterized the CNS pathways regulating airway defensive reflexes and the interactions amongst various afferent nerve subtypes in regulating these reflexes.
Clinical Trials
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Selected Publications
Mazzone SB, Reynolds SR, Mori N, Kollarik M, Farmer DG, Myers AC, Canning BJ (2009). Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough. J Neurosci., 29(43):13662-13671
Canning BJ, Mori N (2010). An essential element to cough gating identified in anesthetized guinea pigs. FASEB J., 24(10):3916-3926
Canning BJ, Mori N (2011). Encoding of the cough reflex in anesthetized guinea pigs. Am J Physiol, 300(2):R369-77
Krasteva G, Canning BJ, Hartmann P, Veres T, Papadakis T et al. (2011). Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U.S.A., 108(23):9478 - 9483
Chou YL, Mori M and Canning BJ (2018). Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs. Am J Physiol, 314(3):R489-R498