We study airway neural control. We have characterized the CNS pathways regulating airway defensive reflexes and the interactions amongst various afferent nerve subtypes in regulating these reflexes.
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Mazzone SB, Reynolds SR, Mori N, Kollarik M, Farmer DG, Myers AC, Canning BJ (2009). Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough. J Neurosci., 29(43):13662-13671
Canning BJ, Mori N (2010). An essential element to cough gating identified in anesthetized guinea pigs. FASEB J., 24(10):3916-3926
Canning BJ, Mori N (2011). Encoding of the cough reflex in anesthetized guinea pigs. Am J Physiol, 300(2):R369-77
Krasteva G, Canning BJ, Hartmann P, Veres T, Papadakis T et al. (2011). Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U.S.A., 108(23):9478 - 9483
Chou YL, Mori M and Canning BJ (2018). Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs. Am J Physiol, 314(3):R489-R498