Arnold Bakker, Ph.D., M.A.

Headshot of Arnold Bakker
  • Director, Psychiatry Neuroimaging Core
  • Associate Professor of Psychiatry and Behavioral Sciences

Research Interests

Cognitive neuroscience of human memory; Neural mechanisms of normal memory function; Impaired memory function in aging and disease using neuropsychological assessment; Experimental behavioral assessment and advanced neuroimaging methods; Structural and functional magnetic resonance imaging; Diffusion tensor imaging and magnetic resonance spectroscopy more



  • Director, Psychiatry Neuroimaging Core
  • Associate Professor of Psychiatry and Behavioral Sciences
  • Associate Professor of Neurology

Departments / Divisions



  • M.A.; Johns Hopkins University (Maryland) (2007)
  • Ph.D.; Johns Hopkins University (Maryland) (2011)
  • B.A.; Tilburg University (The Netherlands) (2002)
  • M.A.; Tilburg University (The Netherlands) (2002)

Research & Publications

Research Summary

My research focuses on the cognitive neuroscience of human memory. I study the neural mechanisms underlying normal memory function and impaired memory function in aging and disease using neuropsychological assessment, experimental behavioral assessment and particularly advanced neuroimaging methods, including structural and functional magnetic resonance imaging, diffusion tensor imaging, and magnetic resonance spectroscopy.


Lab Website: Bakker Memory Laboratory

Clinical Trial Keywords

Mild Cognitive Impairment (MCI); Functional neuroimaging; Memory impairment; Levetiracetam (Keppra)

Clinical Trials

Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)

Selected Publications

View all on PubMed

Tran, T.T., Speck, C.L., Pisupati, A., Gallagher, M., & Bakker, A. (2016). Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment. NeuroImage: Clinical, 13, 237-245.    

Bakker A, Albert MS, Krauss G, Speck CL, Gallagher M., Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance. NeuroImage. Clinical. 2015; 7:688-98. PubMed [journal]PMID: 25844322 PMCID: PMC4377841

Bakker, A., Krauss, G.L., Albert, M.S., Speck, C.L., Jones, L.R., Stark, C.E., Yassa, M.A., Bassett, S.S., Shelton, L., & Gallagher, M. (2012). Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron, 74, 467-474

Marchette, S., Bakker, A., & Shelton, A.L. (2011). Cognitive mappers to creatures of habit: differential engagement of place and response learning mechanisms predicts human navigational behavior. Journal of Neuroscience, 31, 15264-15268

Bakker, A., Kirwan, C.B., Miller, M., & Stark, C.E.L. (2008).  Pattern separation in the human hippocampal CA3 and dentate gyrus. Science, 319, 1640-1642

Contact for Research Inquiries

Phipps Building
600 N. Wolfe Street
Baltimore, MD 21287 map
Phone: 410-502-6944
Fax: 410-614-3676

Email me

Academic Affiliations & Courses

Graduate Program Affiliation

Psychological and Brain Sciences

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