- Director, Psychiatry Neuroimaging Core
- Associate Professor of Psychiatry and Behavioral Sciences
- Associate Professor of Neurology
Arnold Bakker, Ph.D., M.A.
Cognitive neuroscience of human memory; Neural mechanisms of normal memory function; Impaired memory function in aging and disease using neuropsychological assessment; Experimental behavioral assessment and advanced neuroimaging methods; Structural and functional magnetic resonance imaging; Diffusion tensor imaging and magnetic resonance spectroscopy ...read more
My research focuses on the cognitive neuroscience of human memory. I study the neural mechanisms underlying normal memory function and impaired memory function in aging and disease using neuropsychological assessment, experimental behavioral assessment and particularly advanced neuroimaging methods, including structural and functional magnetic resonance imaging, diffusion tensor imaging, and magnetic resonance spectroscopy.
Lab Website: Bakker Memory Laboratory
Mild Cognitive Impairment (MCI); Functional neuroimaging; Memory impairment; Levetiracetam (Keppra)
Tran, T.T., Speck, C.L., Pisupati, A., Gallagher, M., & Bakker, A. (2016). Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment. NeuroImage: Clinical, 13, 237-245.
Bakker A, Albert MS, Krauss G, Speck CL, Gallagher M., Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance. NeuroImage. Clinical. 2015; 7:688-98. PubMed [journal]PMID: 25844322 PMCID: PMC4377841
Bakker, A., Krauss, G.L., Albert, M.S., Speck, C.L., Jones, L.R., Stark, C.E., Yassa, M.A., Bassett, S.S., Shelton, L., & Gallagher, M. (2012). Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron, 74, 467-474
Marchette, S., Bakker, A., & Shelton, A.L. (2011). Cognitive mappers to creatures of habit: differential engagement of place and response learning mechanisms predicts human navigational behavior. Journal of Neuroscience, 31, 15264-15268
Bakker, A., Kirwan, C.B., Miller, M., & Stark, C.E.L. (2008). Pattern separation in the human hippocampal CA3 and dentate gyrus. Science, 319, 1640-1642
Psychological and Brain Sciences