Research Summary
My research focuses on the cognitive neuroscience of human memory. I study the neural mechanisms underlying normal memory function and impaired memory function in aging and disease using neuropsychological assessment, experimental behavioral assessment and particularly advanced neuroimaging methods, including structural and functional magnetic resonance imaging, diffusion tensor imaging, and magnetic resonance spectroscopy.
Lab
Lab Website: Bakker Memory Laboratory
Clinical Trial Keywords
Mild Cognitive Impairment (MCI); Functional neuroimaging; Memory impairment; Levetiracetam (Keppra)
Clinical Trials
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
Selected Publications
View all on PubMed
Tran, T.T., Speck, C.L., Pisupati, A., Gallagher, M., & Bakker, A. (2016). Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment. NeuroImage: Clinical, 13, 237-245.
Bakker A, Albert MS, Krauss G, Speck CL, Gallagher M., Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task performance. NeuroImage. Clinical. 2015; 7:688-98. PubMed [journal]PMID: 25844322 PMCID: PMC4377841
Bakker, A., Krauss, G.L., Albert, M.S., Speck, C.L., Jones, L.R., Stark, C.E., Yassa, M.A., Bassett, S.S., Shelton, L., & Gallagher, M. (2012). Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron, 74, 467-474
Marchette, S., Bakker, A., & Shelton, A.L. (2011). Cognitive mappers to creatures of habit: differential engagement of place and response learning mechanisms predicts human navigational behavior. Journal of Neuroscience, 31, 15264-15268
Bakker, A., Kirwan, C.B., Miller, M., & Stark, C.E.L. (2008). Pattern separation in the human hippocampal CA3 and dentate gyrus. Science, 319, 1640-1642
