Antonio C. Wolff, M.D.

Antonio Carlos Wolff, M.D.

Headshot of Antonio C. Wolff
  • Interim Director, Women's Malignancies Disease Group
  • Professor of Oncology

Languages: English, French, Portuguese, Spanish


Breast Cancer, Cancer Survivorship, Clinical Practice Guidelines, Clinical Trials, Medical Oncology, New Therapies in Breast Cancer, Quality Care, Quality Measures, Risk Assessment and Early Detection more

Research Interests

Breast Cancer

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Insurance Information

Main Phone

Outside of Maryland & Washington D.C.

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International Patients

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Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 410-955-8964
10803 Falls Road
Pavilion III, Suite 1500
Lutherville, MD 21093
Phone: 410-583-2970
Johns Hopkins Medicine - Green Spring Station - Google Maps

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964
401 N. Broadway
Harry and Jeanette Weinberg Building
Baltimore, MD 21231
Phone: 410-614-4192
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center - Google Maps


Dr. Antonio Wolff is a Professor of Oncology at Johns Hopkins University and is Director of Breast Cancer Trials in the Women’s Malignancies Program at the Johns Hopkins Kimmel Comprehensive Cancer Center. He is a practicing breast cancer medical oncologist and translational investigator with expertise in therapeutic clinical trials, biomarker development and implementation, survivorship, clinical practice guidelines, and quality initiatives. He is past member of American Society of Clinical Oncology’s Quality of Care Committee and past Chair of ASCO’s Clinical Practice Guidelines Committee. He is Panel Co-Chair and a lead author/senior author of the ASCO/College of American Pathology clinical practice guidelines on HER2 and hormone receptor testing in breast cancer. He has experience in collaborative, multidisciplinary national and international breast cancer clinical trials and on the integration of research findings into clinical practice. He serves as Chief Operating Officer of the Translational Breast Cancer Research Consortium. In 2009, he received an NCI Cancer Clinical Investigator Team Leadership Award. He serves as Chair of the ECOG-ACRIN Breast Cancer Committee and as member of the Breast Cancer Steering Committee as part of the NCI-funded National Clinical Trials Network (NCTN). He is a Fellow of ASCO and served as a Susan G. Komen Scholar between 2010-2021 and again as of 2023. He was identified in 2017 by Clarivate Analytics (Thomson Reuters) as one of the world’s most highly cited researchers (top 1% in clinical medicine). Dr. Wolff served as Associate Editor of Journal of Clinical Oncology between 2012-2022. At Johns Hopkins, he is a member of the Professorial Promotions Committee of the School of Medicine, and was inducted in 2018 in the JHU Miller Coulson Academy of Clinical Excellence. As part of the 125th anniversary celebration of the JHU School of Medicine, he was also recognized as one of 125 Living the Hopkins Mission Honorees, who were selected for their outstanding dedication to the institution’s core values of excellence and discovery, leadership and integrity, diversity and inclusion, and respect and collegiality. more


  • Interim Director, Women's Malignancies Disease Group
  • Professor of Oncology

Departments / Divisions

  • Oncology - Division of Women's Malignancies

Centers & Institutes



  • MD; Faculdade de Medicina da Universidade Federal do Rio de Janeiro (1986)


  • Internal Medicine; MedStar Health (1990)
  • Internal Medicine; The Mount Sinai Hospital (1991)


  • Medical Oncology; Johns Hopkins University School of Medicine (1995)
  • Hematology and Oncology; Washington University School of Medicine (1992)

Board Certifications

  • American Board of Internal Medicine (Medical Oncology) (1995)

Research & Publications

Clinical Trial Keywords

breast cancer, biomarkers, survivorship

Selected Publications

Wolff AC, Somerfield MR, Dowsett M, Hammond MEH, Hayes DF, McShane LM, Saphner TJ, Spears PA, Allison KH. Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: ASCO-College of American Pathologists Guideline Update. J Clin Oncol. 2023 Jun 7:JCO2202864. doi: 10.1200/JCO.22.02864. Online ahead of print. PMID: 37284804

Santa-Maria CA, Wolff AC. Antibody-Drug Conjugates in Breast Cancer: Searching for Magic Bullets. J Clin Oncol. 2023 Feb 1;41(4):732-735. doi: 10.1200/JCO.22.02217. Epub 2022 Nov 29. PMID: 36446052

Visvanathan K, Cope L, Fackler MJ, Considine M, Sokoll L, Carey LA, Forero-Torres A, Ingle JN, Lin NU, Nanda R, Storniolo AM, Tulac S, Venkatesan N, Wu NC, Marla S, Campbell S, Bates M, Umbricht CB, Wolff AC, Sukumar S. Evaluation of a Liquid Biopsy-Breast Cancer Methylation (LBx-BCM) Cartridge Assay for Predicting Early Disease Progression and Survival: TBCRC 005 Prospective Trial. Clin Cancer Res. 2023 Feb 16;29(4):784-790. doi: 10.1158/1078-0432.CCR-22-2128. PMID: 36534524

Kim HS, Umbricht CB, Illei PB, Cimino-Mathews A, Cho S, Chowdhury N, Figueroa-Magalhaes MC, Pesce C, Jeter SC, Mylander C, Rosman M, Tafra L, Turner BM, Hicks DG, Jensen TA, Miller DV, Armstrong DK, Connolly RM, Fetting JH, Miller RS, Park BH, Stearns V, Visvanathan K, Wolff AC, Cope L. Optimizing the Use of Gene Expression Profiling in Early-Stage Breast Cancer. J Clin Oncol. 2016 Dec 20;34(36):4390-4397. doi: 10.1200/JCO.2016.67.7195. Epub 2016 Oct 31. PMID: 27998227 

Wolff AC, Blackford AL, Visvanathan K, Rugo HS, Moy B, Goldstein LJ, Stockerl-Goldstein K, Neumayer L, Langbaum TS, Theriault RL, Hughes ME, Weeks JC, Karp JE. Risk of marrow neoplasms after adjuvant breast cancer therapy: the national comprehensive cancer network experience. J Clin Oncol. 2015 Feb 1;33(4):340-8. doi: 10.1200/JCO.2013.54.6119. Epub 2014 Dec 22. PMID: 25534386 

Activities & Honors


  • Member, JHU Miller Coulson Academy of Clinical Excellence, 2018
  • Scholar, Susan G Komen Foundation, 2023
  • Fellow, American Society of Clinical Oncology, 2010
  • Recipient, NCI Cancer Clinical Investigator Team Leadership Award, 2010
  • Fellow, American College of Physicians, 2004


  • American Society of Clinical Oncology
  • European Society of Medical Oncology

Professional Activities

  • Associate Editor for Breast Cancer, The Journal of Clinical Oncology, 2012 - 2022
  • Chair, ECOG-ACRIN Breast Cancer Committee, 2018

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