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Anthony Ross Cammarato, Ph.D.

Headshot of Anthony Ross Cammarato
  • Associate Professor of Medicine

Research Interests

Myopathic Processes; Integrative Analysis of Striated Muscle Performance; Hierarchical Modeling and Imaging of Contractile Machinery ...read more

Background

Dr. Anthony Cammarato is an Associate Professor of Medicine and of Physiology. His research interests include the identification and manipulation of age- and mutation-dependent modifiers of cardiac function. His lab performs hierarchical modeling and imaging of contractile machinery and integrative analysis of striated muscle performance and myopathic processes.

Dr. Cammarato holds a bachelor’s degree in Biology from Mary Washington College and a Ph.D., in Physiology and Biophysics, from Boston University School of Medicine. He completed a postdoctoral fellowship at San Diego State University and worked as a staff scientist and later as an assistant research professor at the Sanford-Burnham Medical Research Institute before joining the Johns Hopkins faculty in 2011. He is a member of the American Physiological Society, the Biophysical Society, the American Society for Cell Biology, and the Genetics Society of America.

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Titles

  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D.; Boston University (Massachusetts) (2003)
  • B.S.; Mary Washington College (Virginia) (1995)

Additional Training

  • San Diego State University, San Diego, CA, 2008, Postdoctoral Fellow, Molecular Genetics, Structural Biology, Cardiac Function

Research & Publications

Selected Publications

View all on PubMed

Schmidt W, Madan A, Foster DB, Cammarato A. Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity. J Biol Chem. 2020 Nov 13;295(46):15527-15539. doi: 10.1074/jbc.RA120.015277. Epub 2020 Sep 1.PMID: 32873710

Madan A, Viswanathan MC, Woulfe KC, Schmidt W, Sidor A, Liu T, Nguyen TH, Trinh B, Wilson C, Madathil S, Vogler G, O'Rourke B, Biesiadecki BJ, Tobacman LS, Cammarato A. TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18822-18831. doi: 10.1073/pnas.2001692117. Epub 2020 Jul 20.PMID: 32690703 

Viswanathan MC, Schmidt W, Franz P, Rynkiewicz MJ, Newhard CS, Madan A, Lehman W, Swank DM, Preller M, Cammarato A. A role for actin flexibility in thin filament-mediated contractile regulation and myopathy. Nat Commun. 2020 May 15;11(1):2417. doi: 10.1038/s41467-020-15922-5.PMID: 32415060 

Viswanathan MC, Schmidt W, Rynkiewicz MJ, Agarwal K, Gao J, Katz J, Lehman W, Cammarato A. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy. Cell Rep. 2017 Sep 12;20(11):2612-2625. doi: 10.1016/j.celrep.2017.08.070.PMID: 28903042 

Blice-Baum AC, Zambon AC, Kaushik G, Viswanathan MC, Engler AJ, Bodmer R, Cammarato A. Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age-associated functional decline. Aging Cell. 2017 Feb;16(1):93-103. doi: 10.1111/acel.12543.PMID: 28090761 

Contact for Research Inquiries

Johns Hopkins University
720 Rutland Avenue
Division of Cardiology, Ross 1050
Baltimore, MD 21205 map
Phone: 410-955-1807
Fax: 410-502-2558

Activities & Honors

Memberships

  • Biophysical Society 
    Member
  • Genetics Society of America
    Member
  • The American Physiological Society 
    Member
  • The American Society for Cell Biology 
    Member
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