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Anne Margaret Murphy, M.D.

Anne Margaret Murphy, M.D.

Headshot of Anne Margaret Murphy
  • Vice Chair for Basic and Translational Research, Department of Pediatrics
  • Professor of Pediatrics


Cardiology, Hypertrophic Cardiomyopathy, Inherited Cardiomyopathies, Inherited Heart Diseases, Pediatric Cardiology, Pediatric Congenital Heart Disease more

Research Interests

Long-term management of children; Adolescents and young adults with congenital heart defects; Cardiovascular genetics; Hypertrophic cardiomyopathy; Molecular biology of cardiac muscle more

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Outside of Maryland & Washington D.C.

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 443-997-5437
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, Pediatric Cardiology, M2201
Baltimore, MD 21287 map

Johns Hopkins Health Care and Surgery Center

Appointment Phone: 443-997-5437
6420 Rockledge Drive
Johns Hopkins Children's Center Specialists, Suite 2300
Bethesda, MD 20817 map


Dr. Anne Murphy is a Professor of Pediatrics at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include pediatric congenital heart disease, hypertrophic cardiomyopathy, inherited heart diseases and general pediatric cardiology. She participates in the HCMNet a network that conducts studies and clinical trials in hypertrophic cardiomyopathy. 

Dr. Murphy also serves as the Vice Chair for Basic and Translational Research for the Department of Pediatrics.

She earned her M.D. from Johns Hopkins University School of Medicine and completed her residency at The Johns Hopkins Hospital. She performed a fellowship at Cincinnati Children’s Hospital. She was an attending pediatric cardiologist at St. Louis Children's Hospital prior to her appointment at Johns Hopkins. 

Dr. Murphy maintains a clinical practice as well as a research laboratory. Her laboratory has received grants from the American Heart Association, the National Institutes of Health and the Children's Cardiomyopathy Foundation. She has received the Rowe Award for Cardiology Research from the Society for Pediatric Research and the Meritorious Achievement Award from the American Heart Association Council on Cardiovascular Disease in the Young. Her research on the molecular basis of myocardial stunning was named one of the top 10 research achievements for 1999 by the American Heart Association. 

Dr. Murphy is a fellow of the American College of Cardiology and a member of the Society for Pediatric Research. more


  • Vice Chair for Basic and Translational Research, Department of Pediatrics
  • Professor of Pediatrics
  • Professor of Genetic Medicine

Departments / Divisions

Centers & Institutes



  • MD; Johns Hopkins University School of Medicine (1981)


  • Pediatrics; Johns Hopkins University School of Medicine (1984)


  • Pediatric Cardiology; Cincinnati Childrens Hospital Medical Center (1987)

Board Certifications

  • American Board of Pediatrics (Pediatric Cardiology) (2010)
  • American Board of Pediatrics (Pediatrics) (1986)

Research & Publications

Clinical Trials

Valsartan for Attenuating Disease Evolution In Early Sarcomeric HCM (VANISH)

Selected Publications

View all on PubMed

Genetic Dilated Cardiomyopathy Due to TTN Variants Without Known Familial Disease. Brown EE, Murray B, Vaishnav J, Tampakakis E, Barouch LA, James C, Murphy AM, Judge DP. Circ Genom Precis Med. 2020 Dec;13(6):e003082. doi: 10.1161/CIRCGEN.120.003082. Epub 2020 Nov 15. PMID: 33190517 No abstract available.

Baseline Characteristics of the VANISH Cohort. Axelsson Raja A, Shi L, Day SM, Russell M, Zahka K, Lever H, Colan SD, Margossian R, Hall EK, Becker J, Jefferies JL, Patel AR, Choudhury L, Murphy AM, Canter C, Bach R, Taylor M, Mestroni L, Wheeler MT, Benson L, Owens AT, Rossano J, Lin KY, Pahl E, Pereira AC, Bundgaard H, Lewis GD, Vargas JD, Cirino AL, McMurray JJV, MacRae CA, Solomon SD, Orav EJ, Braunwald E, Ho CY. Circ Heart Fail. 2019 Dec;12(12):e006231. doi: 10.1161/CIRCHEARTFAILURE.119.006231. Epub 2019 Dec 9. PMID: 31813281 Free PMC article. Clinical Trial.

Genetic aetiologies should be considered in paediatric cases of acute heart failure presumed to be myocarditis. Brown EE, McMilllan KN, Halushka MK, Ravekes WJ, Knight M, Crosson JE, Judge DP, Murphy AM. Cardiol Young. 2019 Jul;29(7):917-921. doi: 10.1017/S1047951119001124. Epub 2019 Jun 14. PMID: 31198128

Prevalence and Progression of Late Gadolinium Enhancement in Children and Adolescents With Hypertrophic Cardiomyopathy. Axelsson Raja A, Farhad H, Valente AM, Couce JP, Jefferies JL, Bundgaard H, Zahka K, Lever H, Murphy AM, Ashley E, Day SM, Sherrid MV, Shi L, Bluemke DA, Canter CE, Colan SD, Ho CY. Circulation. 2018 Aug 21;138(8):782-792. doi: 10.1161/CIRCULATIONAHA.117.032966. PMID: 29622585

Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo. Li Y, Zhu G, Paolocci N, Zhang P, Takahashi C, Okumus N, Heravi A, Keceli G, Ramirez-Correa G, Kass DA, Murphy AM. Circ Heart Fail. 2017 Sep;10(9):e003850. doi: 10.1161/CIRCHEARTFAILURE.117.003850. PMID: 28899987

Activities & Honors


  • Rowe Award for Cardiology Research, Society for Pediatric Research
  • Clinician-Scientist Award, American Heart Association
  • Meritorious Achievement Award, American Heart Association Council on Cardiovascular Disease in the Young, 2016


  • Fellow American College of Cardiology
  • Society for Pediatric Research
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