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Anne Marie Spalding Comi, M.D.

Headshot of Anne Marie Spalding Comi
  • Professor of Neurology



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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-614-1522
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 443-923-9150

Johns Hopkins Outpatient Center

601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 443-923-9150


Dr. Comi graduated from SUNY Buffalo School of Medicine and received her training in pediatrics at the Children's Hospital of Buffalo and her child neurology training at Johns Hopkins Medicine. Her clinical specialization is in the treatment of the neurological aspects of Sturge-Weber syndrome and other disorders related to capillary malformation.

Dr. Comi's clinical research interests focus on improving the early diagnosis and treatment of brain involvement in Sturge-Weber syndrome in order to prevent ischemic brain injury in affected infants and young children, and on studies to understand what causes Sturge-Weber syndrome. Her laboratory research work deals with the pathogenesis of Sturge-Weber syndrome, recently shown to be caused by a somatic mutation, and on developing new drug targets, screening assays, models and therapeutic strategies for Sturge-Weber syndrome. Her lab group also works on developing better neuroprotective and neuroregenerative responses to brain injury resulting from impaired blood flow to the brain. more


  • Professor of Neurology
  • Professor of Pediatrics

Departments / Divisions



  • MD; Medicine; SUNY at Buffalo School of Medicine (1993)


  • Neurology; Johns Hopkins University School of Medicine (1999)
  • Neurology; Women & Children's Hospital of Buffalo (1996)

Board Certifications

  • American Board of Psychiatry and Neurology (Neurology/Special Child Neurology) (2000)
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