Ana-Maria Orbai, M.D., M.H.S.

Headshot of Ana-Maria Orbai
  • Director, Psoriatic Arthritis Program
  • Associate Professor of Medicine

Languages: English, Romanian


Autoimmune Diseases, Psoriatic Arthritis, Rheumatology, Spondyloarthritis more

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Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-8089
4940 Eastern Avenue
Asthma and Allergy Center
Baltimore, MD 21224 map
Phone: 410-550-8089 | Fax: 410-550-5601


Dr. Ana-Maria Orbai is an Assistant Professor of Medicine in the Division of Rheumatology at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include rheumatology and psoriatic arthritis.

Dr. Orbai earned her M.D. from the Iuliu Hatieganu School of Medicine and Pharmacy, Cluj-Napoca, in Romania. She completed internship and residency training in internal medicine at the Johns Hopkins University-Sinai Hospital program. Subsequently, Dr. Orbai completed her post-doctoral fellowship training in rheumatology at Johns Hopkins. During her fellowship she earned her Master in Health Sciences degree in Clinical Investigation at the Johns Hopkins Bloomberg School of Public Health.

Dr. Orbai directs the Psoriatic Arthritis Program in the Johns Hopkins Arthritis Center.  Her clinical focus is psoriatic arthritis and spodyloarthritis.

Dr. Orbai's research aims to understand psoriatic disease subtypes and improve treatment strategies for people with psoriatic arthritis. Dr. Orbai was awarded a Rheumatology Research Foundation Scientist Development award in 2014 and a Jerome L Greene Foundation Scholar award in 2018. more


  • Director, Psoriatic Arthritis Program
  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD; Iuliu Hatieganu University of Medicine and Pharmacy - Romania (2004)


  • Internal Medicine; Sinai Hospital (2010)


  • Rheumatology; Johns Hopkins University School of Medicine (2013)

Board Certifications

  • American Board of Internal Medicine (Internal Medicine) (2010)
  • American Board of Internal Medicine (Rheumatology) (2012)

Research & Publications

Research Summary

Dr. Orbai directs the Psoriatic Arthritis Program in the Johns Hopkins Arthritis Center. Her research focus is characterization of psoriatic disease phenotypes and individualizing treatment strategies. The goal is to improve long-term patient outcomes in psoriatic arthritis.Dr. Orbai co-chaired the international GRAPPA-OMERACT Psoriatic Arthritis working group through their update of the PsA core outcome set for clinical trials in 2016.  She subsequently led the endorsement of the first core patient reported outcome measure for psoriatic arthritis clinical trials in 2018. Dr. Orbai has been an expert panel member for treatment recommendations for psoriatic arthritis. Dr. Orbai serves on the steering committee of Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and on the Board of Medical Directors for the National Psoriasis Foundation.  She is a reviewer for many rheumatology journals.

Dr. Orbai contributed to the development of the 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria for systemic lupus erythematosus with Dr. Michelle Petri in the Johns Hopkins Lupus Center.


Lab Website: Ana-Marie Orbai Lab

Technology Expertise Keywords

Psoriatic arthritis; Patient reported outcomes; Core outcomes; Clinical trials

Selected Publications

View all on PubMed

Orbai AM, Holland R, Leung YY, Tillett W, Goel N, Christensen R, McHugh N, Gossec L, de Wit M, Højgaard P, Coates LC, Mease PJ, Birt J, Fallon L, FitzGerald O, Ogdie A, Shea B, Strand V, Callis Duffin K, Tugwell P, Beaton D, Gladman DD. PsAID12 Provisionally Endorsed at OMERACT 2018 as Core Outcome Measure to Assess Psoriatic Arthritis-specific Health-related Quality of Life in Clinical Trials. J Rheumatol. 2018 Dec 15. pii: jrheum.181077. doi: 10.3899/jrheum.181077. [Epub ahead of print] PMID: 30554154

Singh JA, Guyatt G, Ogdie A, Gladman DD, Deal C, Deodhar A, Dubreuil M, Dunham J, Husni ME, Kenny S, Kwan-Morley J, Lin J, Marchetta P, Mease PJ, Merola JF, Miner J, Ritchlin CT, Siaton B, Smith BJ, Van Voorhees AS, Jonsson AH, Shah AA, Sullivan N, Turgunbaev M, Coates LC, Gottlieb A, Magrey M, Nowell WB, Orbai AM, Reddy SM, Scher JU, Siegel E, Siegel M, Walsh JA, Turner AS, Reston J. Special Article: 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis. Arthritis Rheumatol. 2019 Jan;71(1):5-32. doi: 10.1002/art.40726. Epub 2018 Nov 30. PMID: 30499246

Gorlier C, Orbai AM, Puyraimond-Zemmour D, Coates LC, Kiltz U, Leung YY, Palominos P, Cañete JD, Scrivo R, Balanescu A, Dernis E, Tälli S, Ruyssen-Witrand A, Soubrier M, Aydin SZ, Eder L, Gaydukova I, Lubrano E, Kalyoncu U, Richette P, Husni ME, de Wit M, Smolen JS, Gossec L. Comparing patient-perceived and physician-perceived remission and low disease activity in psoriatic arthritis: an analysis of 410 patients from 14 countries. Ann Rheum Dis. 2018 Nov 15. pii: annrheumdis-2018-214140. doi: 10.1136/annrheumdis-2018-214140. [Epub ahead of print] PMID: 30442648

Orbai AM, de Wit M, Mease P, Shea JA, Gossec L, Leung YY, Tillett W, Elmamoun M, Callis Duffin K, Campbell W, Christensen R, Coates L, Dures E, Eder L, FitzGerald O, Gladman D, Goel N, Grieb SD, Hewlett S, Hoejgaard P, Kalyoncu U, Lindsay C, McHugh N, Shea B, Steinkoenig I, Strand V, Ogdie A. International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials.Ann Rheum Dis. 2017 Apr;76(4):673-680. doi: 10.1136/annrheumdis-2016-210242. Epub 2016 Sep 9. PMID: 27613807

Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, Sánchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth VP, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta MA, Jacobsen S, Buyon JP, Maddison P, Dooley MA, van Vollenhoven RF, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim SS, Fessler BJ, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG Jr, Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman MH, McGwin G Jr, Magder LS. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012 Aug;64(8):2677-86. doi: 10.1002/art.34473. PMID: 22553077

Activities & Honors


  • Scientist Development Award, Rheumatology Research Foundation, 2014 - 2017
  • Jerome L Greene Foundation Scholar, Jerome L Greene Foundation, 2018


  • American College of Rheumatology


  • Maryland Society for the Rheumatic Diseases


  • Group for Research and Assessment of Psoriasis and Psoriatic Arthritis

Videos & Media

Recent News Articles and Media Coverage

Arthritis Makes Life With Chronic Diseases Worse, U.S. News & World Report, Aug. 6, 2015

What Are Common Symptoms of Autoimmune Disease?, Johns Hopkins Medicine

Autoimmune Disease: Why Is My Immune System Attacking Itself? Johns Hopkins Medicine

Psoriatic Arthritis – Disease Overview, Johns Hopkins Medicine, Johns Hopkins Rheumatology (May 7, 2018)

Diagnosing Psoriatic Arthritis, Johns Hopkins Rheumatology (May 9, 2018)

Treating Psoriatic Arthritis, Johns Hopkins Rhematology (May 10, 2018)

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