Alexander Hillel, M.D.

Alexander Tell Hillel, M.D.

Headshot of Alexander Hillel
  • Professor of Otolaryngology - Head and Neck Surgery


Airway Disorders, Dysphonia, Hoarseness, Laryngeal Disorders, Laryngeal Stenosis, Laryngeal Surgery, Otolaryngology, Otolaryngology (ENT), Tracheal Stenosis, Voice Problems more

Research Interests

Tracheal transplantation; Laryngeal tissue engineering; Development of biomaterial therapeutics for subglottic stenosis; Laryngeal and soft tissue fillers more

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Outside of Maryland & Washington D.C.

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Johns Hopkins Outpatient Center (now called Levi Watkins, Jr., M.D., Outpatient Center)

Appointment Phone: 443-997-6467
601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-955-1654 | Fax: 410-367-2300

Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 443-997-6467
10803 Falls Road
Pavilion III, Suite 2500
Lutherville, MD 21093 map
Fax: 410-367-2300

Johns Hopkins Health Care and Surgery Center

6420 Rockledge Drive
Suite 4920
Bethesda, MD 20817 map
Phone: 301-896-3332 | Fax: 301-530-2650


Alexander Hillel received his M.D. from the Tulane University School of Medicine, completed his residency at the Johns Hopkins University School of Medicine, and a fellowship in Laryngology at the Emory Voice Center. Dr. Hillel specializes in the medical and surgical management of patients who have scar tissue blocking their larynx and/or trachea, a condition called laryngotrachealstenosis. This condition occurs in patients who have had prolonged intubation, autoimmune disease, and a rare disease called idiopathic subglottic stenosis. He also treats patients with voice and throat problems, including spasmodic dysphonia, and swallowing difficulty.

Dr. Hillel’s research seeks to better understand why scar forms in the larynx and trachea.  He and his team investigate the relationship among the immune system, bacteria, and scar formation in the airway in an effort to improve treatment.  They are also testing drugs that may halt the progression of, or reverse, scar formation and engineered a drug-eluting stent which is being tested to translate to patients with laryngotrachealstenosis. Dr. Hillel holds sponsored grants from the National Institute of Health, surgical foundations, and the medical device industry to conduct his research.

In addition to clinical and research work, Dr. Hillel holds a leadership role within the Department, serving as the Residency Program Director and Vice Director of Education. He leads 25 resident physicians and serves as the critical communication node between faculty and residents.

This provider is registered with the Florida Department of Health to perform telehealth services for patients in Florida. more


  • Professor of Otolaryngology - Head and Neck Surgery
  • Professor of Anesthesiology and Critical Care Medicine

Departments / Divisions

Centers & Institutes



  • MD; Tulane University School of Medicine (2004)


  • Otolaryngology Head and Neck Surgery; Johns Hopkins University School of Medicine (2010)


  • Otolaryngology; Emory University School of Medicine (2012)

Board Certifications

  • American Board of Otolaryngology - Head and Neck Surgery (Otolaryngology-General) (2011)

Research & Publications


Dr. Alexander Hillel's clinical practice and research focuses centers on risk factors for, the prevention of, and treatment for laryngotracheal stenosis (LTS) and other diseases of the trachea and larynx. His laboratory developed robust in vitro and in vivo model systems to study immunologic and metabolic mechanisms promoting laryngotracheal inflammation, airway wall remodeling, and fibrosis to develop new therapies targeting airway disease. Ongoing efforts include applying a novel drug-eluting stent to influence to treat laryngotracheal stenosis. He serves on the leadership team of the North American Airway Collaborative (NoAAC) which is an international organization dedicated to improving our understanding of adult airway disease and developing effective, cost-conscious treatments.

Lab Website: Hillel Laboratory

Selected Publications

View all on PubMed

Murphy MK, Motz K, Ding D, Yin LX, Duvvuri MV, Feeley M, Hillel AT. Targeting metabolic abnormalities to reverse fibrosis in iatrogenic laryngotracheal stenosis. Laryngoscope. 2018;128:E59-67. PMID: 28940431.  PMC5771827.

Ma G, Samad I, Ding D, Namba DR, Elisseeff JH, Horton MR, Hillel AT. Metabolic variations in normal and fibrotic human laryngotracheal derived fibroblasts in vitro. Laryngoscope. 2017;127:E107-13. PMID: 27585358. PMC5321789.

Gadkaree S, Pandian V, Best SA, Motz K, Allen C, Kim Y, Akst LM, Hillel AT. Laryngotracheal stenosis: Risk factors for tracheostomy dependence and dilation interval.  Otolaryngol Head Neck Surg. 2017;156:321-8. PMID: 28112014. PMC5348246.

Motz K, Yin LX, Samad I, Ding D, Murphy MK, Duvvuri MV, Hillel AT.  Quantification of inflammatory markers in laryngotracheal stenosis. Otolaryngol Head Neck Surg. 2017;156:321-8. PMID: 28485188. PMC5593763.

Hillel AT, Gelbard A. Unleashing rapamycin on fibrosis. Oncotarget. 2015;6:15722-3. PMID: 26158293. PMC: 4599220.

Videos & Media

Recent News Articles and Media Coverage

Comprehensive Treatment of Laryngotracheal Stenosis, HeadWay (Winter 2017)

The Johns Hopkins Voice Center: Speaking Up, Johns Hopkins Bayview News (Fall 2013)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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