Research Summary
Akhil Maheshwari is an internationally recognized expert in neonatal intestinal injury and associated innate immune response. His major scientific contributions include mechanisms underlying the unique susceptibility of premature neonates to intestinal injury, role of macrophages in NEC, role of RBC transfusions in neonatal intestinal injury, and unique developmental roles of inflammatory mediators. His laboratory has developed several preclinical and clinical models to investigate the mechanisms of NEC. He has been continuously funded by the NIH through the R01 mechanism since 2007, and currently has two major lines of investigation, each supported through the R01 mechanism, focused on RBC transfusions and platelet transfusions in NEC, respectively. Dr. Maheshwari has authored or co-authored more than 100 manuscripts and book chapters, edited two textbooks of neonatology, and has been awarded several patents for novel anti-inflammatory agents. He serves on the editorial boards of several professional journals and is an active reviewer for many others. He sits on grant review committees at the NIH, Canadian Institutes for Health Research, American Heart Association, and on several similar committees in Europe and Asia.
Clinical Trials
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Selected Publications
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Ho TTB, Groer MW, Kane B, Yee AL, Torres BA, Gilbert JA, Maheshwari A. Dichotomous development of the gut microbiome in preterm infants. Microbiome. 2018; 6(1):157. PMID: 30208950, PMCID: PMC6136210
Maheshwari A, Kelly DR, Nicola T, Ambalavanan N, Jain SK, Murphy-Ullrich J, Athar M, Shimamura M, Bhandari V, Aprahamian C, Dimmitt RA, Serra R, Ohls RK. TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology. 2011; 140(1):242-53. NIHMSID: NIHMS239996; PMID: 20875417, PMCID: PMC3008335
Clinics in Perinatology, Special edition on Necrotizing Enterocolitis. Denning PW, Maheshwari A (eds); Mar 2013;40 (1)
Hematology, Immunology, and Infectious Disease: Neonatology Questions and Controversies. Ohls RK, Maheshwari A (eds). Philadelphia, Elsevier, 2nd Ed. 12 Mar 2012; ISBN-13: 978-1437726626
Hematology, Immunology & Genetics: Neonatology Questions and Controversies. Ohls RK, Maheshwari A, Christensen RD (Eds.). Philadelphia, Elsevier, 3rd Ed. 4 Sep 2018; ISBN-18: 978-0323544009; eBook ISBN: 978-0323568470; 978-0323568487
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