Research Summary
Dr. Dobs is presently an active investigator in the field of sex hormone disorders and a clinical investigator who has published extensively in HIV-related endocrinopathies and risks and benefits of testosterone replacement therapies.
Lab
Lab Website: Adrian Dobs Lab
Core Facility:
Clinical Trial Keywords
Hormone replacement therapy men and women, hyperlipidemia, diabetes
Selected Publications
Research Support.
Ongoing Research Support:
RO1 DA1409801 (Dobs AS) 06/15/03 05/31/09
NIDA/NIH Cognitive Consequences of Endocrine Dysfunction in Injection Drug Users
Role: Principal Investigator
The major goal of this project is to investigate the consequences of hypogonadal endocrine dysfunction in injection drug users with and without HIV.
2U01 AI35042-07 (Margolick JB) 04/01/04 03/31/11
NIAID/NIH Multi-Center AIDS Cohorts
Role: Co-Investigator
The major goal of this project is to determine metabolic abnormalities of HIV disease.
R03DA026038 09/30/08 9/29/10
Serum Sex Hormones and Cardiovascular Risk in the MACS
The major goal of this project is to study the relationship of sex steroids to heart disease
Principal Investigator
Publications
1. Paller CJ, Shiels MS,Rohrmann S, Basaria S, Rifai N, Nelson W, Platz EA, Dobs A, Relationship of Sex Streriod Hormones with Bone Mineral Density in a Nationally-Representative Sample of Men, Clin Endocrinol (Oxf) May 2008 (E-pub ahead of print) PMID 18485120
2. Wohl D, Scherzer R, Heymensfield S, Simberkoff M, Sidney S, Bacchetti P, Grunfeld C:FRAM Study Investigators (including Dobs A), The Associations of Regional Adipose Tissue with Lipid and Lipoprotein Levels in HIV Infected Men, J Aquir Immune Defic Syndr. , May 2008 48 (1):44-52.
3. Brown T, Jacobson L, Xu X, Tang Y, Qaqish R, Kingsley L, Palella F, Witt M, Visscher B, Dobs A, The Relationship Between Inflammatory Markers, the Metabolic Syndrome and Body Composition Among HIV Seropositive and Seronegative Men: Two Nested Case-Control Studies from the Multicenter AIDS Cohort Study, Conference on Retroviruses and Oppurtunistic Infections.
4. Dobs A, Mortgentaler A, Does Testosterone Therapy Increase the Risk of Prostate Cancer?Endocr.Prac.,2008,14,7,904-911 PMID 18996823
Eckman A, Dobs A, Drug-Induced Gynecomastia,Expert Opin.Drug Saf..,2008,7,6,691-702, England PMID 18983216
5. Mortgentaler A, Dobs AS, Kaufman JM, Miner MM, Shsbsigh R, Swerdloff, RS, Wang C. Long Acting Testosterone Therapyin Men with Hypogonadism: Results of a Pharmacokinetic Clinical Study, JUrol.,2008,180,6,2307-2313,United States, PMID 18930255
6. Ouyang P, Vaidya D, Dobs A, Golden S, Szklo M, Heckbert S, Kopp P, Gapstur S, Sex Hormone Levels and Subclinical Atherosclerosis , Atherosclerosis, 2008 PMID 18849030
7. Andrade A, Hendrix C, Parsons T, Caballero B, Yuan C, Flexner C, Dobs A, Brown T, BMC Complementary and Alternative Medicine.,2008,8,50,England, PMID 18713456
8. Vaidya D, Dobs A, Gapstur S, Golden S, Hankinson A, Liu K, Ouyang P, The Association of Endogenous Sex Hormones with Lipoprotein Subfraction Profile in the Multi-Ethnic Study of Atheroschlerosis, Metabolism, 2008,57,6,782-790, United States, PMID 18502260
9. Pfeil E., Dobs A, Current and Future Testosterone Delivery Systems for Treatment of the Hypogonadal Male, Expert Opin. Drug Deliv., 2008 5,4,471-481, England, PMID 18426387
10. Cofrancesco J, Scherzer R, Tien P, Gilbert C, Southwell H, Sidney S, Dobs A, Grunfeld C, Illicit Drug Use and HIV Treatment Outcomes in a US Cohort, AIDS,2008,22,3,357-365, England, PMID 18195562
Journal Citations
Basaria, S.; Muller, D.C.; Carducci, M.A.; Egan, J.; Dobs, A.S. Hyperglycemia and insulin resistance in men with prostate carcinoma who receive androgen-deprivation therapy. Cancer. 2006 Feb 1;106(3):581-588.
Braga-Basaria, M.; Dobs, A.S.; Muller, D.C.; Carducci, M.A.; John, M.; Egan, J.; Basaria, S. Metabolic syndrome in men with prostate cancer undergoing long-term androgen-deprivation therapy. J Clin Oncol. 2006 Aug 20;24(24):3979-3983.
Braga-Basaria, M.; Muller, D.C.; Carducci, M.A.; Dobs, A.S.; Basaria, S. Lipoprotein profile in men with prostate cancer undergoing androgen deprivation therapy. International journal of impotence research. 2006 Sep-Oct;18(5):494-498.
Levinson, N.M.; Kuchment, O.; Shen, K.; Young, M.A.; Koldobskiy, M.; Karplus, M.; Cole, P.A.; Kuriyan, J. A Src-like inactive conformation in the abl tyrosine kinase domain. PLoS Biol. 2006 May;4(5):e144.
Maggio, M.; Blackford, A.; Taub, D.; Carducci, M.; Ble, A.; Metter, E.J.; Braga-Basaria, M.; Dobs, A.; Basaria, S. Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy. J Androl. 2006 Nov-Dec;27(6):725-728.
Basaria, S.; Muller, D.C.; Carducci, M.A.; Egan, J.; Dobs, A.S. Relation between duration of androgen deprivation therapy and degree of insulin resistance in men with prostate cancer. Archives of internal medicine. 2007 Mar 26;167(6):612-613.
Rohrmann, S.; Nelson, W.G.; Rifai, N.; Brown, T.R.; Dobs, A.; Kanarek, N.; Yager, J.D.; Platz, E.A. Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans. J Clin Endocrinol Metab. 2007 Jul;92(7):2519-2525.
Selvin, E.; Feinleib, M.; Zhang, L.; Rohrmann, S.; Rifai, N.; Nelson, W.G.; Dobs, A.; Basaria, S.; Golden, S.H.; Platz, E.A. Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III). Diabetes Care. 2007 Feb;30(2):234-238.
Paller, C.J.; Shiels, M.S.; Rohrmann, S.; Basaria, S.; Rifai, N.; Nelson, W.; Platz, E.A.; Dobs, A. Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men. Clinical endocrinology. 2009 Jan;70(1):26-34.
Sharma, P.; Wisniewski, A.; Braga-Basaria, M.; Xu, X.; Yep, M.; Denmeade, S.; Dobs, A.S.; DeWeese, T.; Carducci, M.; Basaria, S. Lack of an effect of high dose isoflavones in men with prostate cancer undergoing androgen deprivation therapy. J Urol. 2009 Nov;182(5):2265-2272.
Shiels, M.S.; Rohrmann, S.; Menke, A.; Selvin, E.; Crespo, C.J.; Rifai, N.; Dobs, A.; Feinleib, M.; Guallar, E.; Platz, E.A. Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men. Cancer Causes Control. 2009 Aug;20(6):877-886.
Menke, A.; Guallar, E.; Rohrmann, S.; Nelson, W.G.; Rifai, N.; Kanarek, N.; Feinleib, M.; Michos, E.D.; Dobs, A.; Platz, E.A. Sex steroid hormone concentrations and risk of death in US men. Am J Epidemiol. 2010 Mar 1;171(5):583-592.
Mondul, A.M.; Selvin, E.; Rohrmann, S.; Menke, A.; Feinleib, M.; Kanarek, N.; Rifai, N.; Dobs, A.S.; Platz, E.A. Association of serum cholesterol and cholesterol-lowering drug use with serum sex steroid hormones in men in NHANES III. Cancer Causes Control. 2010 Oct;21(10):1575-1583.
