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Adam Kaplin, M.D.

Adam Ian Kaplin, M.D.

Headshot of Adam Kaplin
  • Clinical Director, Johns Hopkins Psychiatric Esketamine Clinic


Adult Psychiatry, AIDS Psychiatry, Multiple Sclerosis, Psychiatry, Psychiatry and Behavioral Sciences more

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The Johns Hopkins Hospital

Appointment Phone: 410-614-3307
600 N. Wolfe Street
Meyer Building Suite 121
Baltimore, MD 21287 map
Phone: 410-929-5544 | Fax: 410-934-4224


Dr. Adam Kaplin is a neuropsychiatrist in Baltimore, caring for patients with central nervous system (CNS) neuroinflammatory diseases, such as multiple sclerosis (MS) and related MS spectrum diseases. As one of the few psychiatrists in the U.S. who specializes in MS, he treats people who have MS and other CNS neuroinflammatory diseases with neuropsychiatric symptoms. Patients travel from all over the country – and as far away as the Middle East – to see him. Dr. Kaplin is the principal psychiatric consultant to the Johns Hopkins Multiple Sclerosis Center of Excellence and the clinical director of the Johns Hopkins Psychiatric Esketamine Clinic. 

He graduated magna cum laude from Yale University before earning his M.D. and Ph.D. at Johns Hopkins, where he was a Medical Science Training Program awardee. He went on to complete an internship in internal medicine at Johns Hopkins Bayview Medical Center and a residency in psychiatry at Johns Hopkins Hospital, where he served as the chief resident of psychiatry.

Dr. Kaplin performs both pre-clinical and clinical research on the biological basis of immune-mediated mood disorders and cognitive impairment, with the goal of elucidating novel therapeutic strategies for neuroinflammatory and neurodegenerative disorders. 

To enhance his clinical research, he has become progressively more involved in health information technology, especially as it applies to mental health care and research. He invented and co-developed a mobile, automated, SMS- and web-based platform that serves as both a patient electronic diary and HIPAA-compliant virtual chart that facilitates patient, family and health care provider collaboration of care. He has also been involved in the testing of other novel technologies, such as the DANA tablet-based software that provides exquisitely sensitive and reliable mobile cognitive assessment.    

Dr. Kaplin serves as review editor of Frontiers in Neurology, Frontiers in Neuroscience and Frontiers in Psychiatry. more


  • Clinical Director, Johns Hopkins Psychiatric Esketamine Clinic

Departments / Divisions

Centers & Institutes



  • MD PhD; Medicine; Johns Hopkins University School of Medicine (1996)


  • Psychiatry; Johns Hopkins University School of Medicine (2000)

Board Certifications

  • American Board of Psychiatry and Neurology (Psychiatry-General) (2001)

Research & Publications

Research Summary

  1. Investigating the biological basis of depression and cognitive impairment in autoimmune CNS diseases, such as Multiple Sclerosis.
  2. Developing novel treatments for depression that prevent the potential suicidality that has been associated with SSRIs and led to their black box warning.
  3. Testing a novel treatment for cognitive impairment in MS by first testing it in an animal model of MS (i.e., experimental autoimmune encephalomyelitis).
  4. Developing a bioassay to predict responses in the use of high-dose cyclophosphamide, which has shown unprecedented results in restoring function and stopping disease activity in pilot studies in MS.
  5. Developing a novel technology to monitor patients’ subjective mental phenomena (e.g., mood, anxiety, pain, sleep) in the outpatient setting.
  6. Development and testing of an automated mHealth system to study suicide crisis interventions and link individuals to care.

Selected Publications

Wang M, Kaplin AI. “Explaining naltrexone’s interference with ketamine’s antidepressant effect.” Am J Psychiatry. 2019 May;176:5

Hollinger KR, Alt J, Rais R, Kaplin AI, Slusher BS. “The NAAG'ing concerns of modeling human Alzheimer's disease in mice.” J Alzheimers Dis. 2019;68(3):939-945

Kalmbach DA, Fang Y, Arnedt JT, Cochran AL, Deldin PJ, Kaplin AI, Sen S. “Effects of sleep, physical activity, and shift work on daily mood: A prospective mobile monitoring study of medical interns.” J Gen Intern Med. 2018 Jun;33(6):914-920

Hollinger KR, Woods SR, Adams-Clark A, Choi SY, Franke CL, Susukida R, Thompson C, Reti IM, Kaplin AI. “Defense automated neurobehavioral assessment accurately measures cognition in patients undergoing electroconvulsive therapy for major depressive disorder.” J ECT. 2018 Mar;34(1):14-20

Pinto MD, Greenblatt AM, Williams BL, Kaplin AI. “Exploring the mechanism of the clinical encounter on depressive symptoms in young adults: A path analysis.” Issues Ment Health Nurs. 2017 Jul;38(7):533-539

Academic Affiliations & Courses

Courses and Syllabi

  • T32 Seminar: Ethics, Morbidity, and Mortality
    Johns Hopkins Medicine, Department of Psychiatry
  • How Science is Really Done. A Personal Account from Successful Scientists
    Johns Hopkins Medicine, Department of Psychiatry
  • Medical Student Psychiatry Course
    Johns Hopkins Medicine, Department of Psychiatry and Behavioral Sciences
    2007 - 2015
  • Becoming a Successful Scientific Faculty Member
    Johns Hopkins Medicine, Department of Psychiatry
    2009 - 2010

Activities & Honors


  • ELITE Tech-Know Geek, PM360, 2014
  • Baltimore Magazine Top Psychiatrist, 2012

Professional Activities

  • Review Editor, Frontiers in Neurology, Frontiers in Neuroscience and Frontiers in Psychiatry, 2019
  • Scientific and Medical Advisor on CBT for MS Project, Pear Therapeutics, 2017
  • Founding Medical Advisor; Member of Board of Advisors, Cure Addiction Now, 2017
  • Medical Advisor, Memotext, 2016
  • Medical Advisor, MS Cure Project, 2015
  • Steering Committee Member, Johns Hopkins University Global mHealth Initiative (JHU-GmI), 2014
  • Board of Scientific Advisors, Apellis Pharmaceutical, 2014
  • Board of Advisors, Crisis Text Line, 2013
  • Board of Scientific Advisors, Anthrotronix, 2012
  • Board of Medical Advisors, Remedy Health, 2008
  • Scientific and Medical Advisor, Nancy Davis Center Without Walls MS Foundation, 2005
  • Board Member and Chief Scientific Advisor, Cody Unser First Step Foundation, 2005
  • Faculty Member, Member of the Scientific Advisory Council and Operating Committee, 2004
  • Chairman of Scientific Advisory Board, Montel Williams MS Foundation, 2003
  • Medical Advisory Board Member, International Transverse Myelitis Association, 2002

Videos & Media

Recent News Articles and Media Coverage

Paxil Unsafe for Teenagers, KCSW, Sept. 21, 2015

People with Paralysis Explore Therapeutic Effects of Scuba Diving, Washington Post, Sept. 15, 2014

Apps for Mastering Your Mood, Time, July 18, 2013

Sharing Psychiatric Records Helps Care, New York Times, Jan. 7, 2013

How Keeping Psych Records Too Private Can Hurt Patient Care, Time, Jan. 7, 2013

Clues in the Cycle of Suicide, New York Times, June 24, 2013

Apps Alert the Doctor When Trouble Looms, New York Times, Oct. 8, 2012

Scuba Diving Could Raise Hope for the Paralyzed, CBS News, Oct. 27, 2011

Scuba Diving May Hold Promise for Paraplegic, Baltimore Sun, Oct. 15, 2011

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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