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Sridhar Nimmagadda

Sridhar Nimmagadda

Primary Department Affiliation: Radiology
Joint:  Medicine
Secondary: Pharmacology and Molecular Sciences and Oncology
Degree: Ph.D., Wayne State University
Rank: Associate Professor
Phone: 410-502-6244
Fax: 410-614-3147
School of Medicine Address: 491 CRB II, 1550 Orleans Street, Baltimore, MD  21287

Chemokine receptor biology and molecular imaging applications in drug development.

To understand tumor response to therapy, our laboratory works at the intersection of chemistry and biology, drawing on extensive expertise in chemical, radiochemical, and biocongugate -techniques, molecular imaging methodologies, and animal models. We synthesize imaging agents and therapeutics with a focus on cancer and immune -cell expressed proteins, including chemokine receptors (e.g., CXCR4) and the immune checkpoint proteins (e.g., PD-L1), and integrate those novel chemical tools with innovative imaging techniques to guide and optimize molecularly targeted combination therapies.  

Representative Publications:  

  • Chatterjee S, Behnam Azad B, Nimmagadda S. The intricate role of CXCR4 in Cancer. Adv Cancer Res. 124:31-82, 2014. Pub Med Reference

  • Behnam Azad B, Chatterjee S, Lisok A, Lesniak W, Pullambhatla M, Pomper MG, Nimmagadda S.  A fully human CXCR4 antibody demonstrates diagnostic and therapeutic utility in solid tumor xenografts. Oncotarge Mar 15;7(11):12344-58, 2016. Pub Med Reference

  • Chatterjee S, Lesniak W, Gabrielson M, Lisok A, Wharram B, Sysa-Shah P, Behnam Azad B, Poper MG, Nimmagadda S.  A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors. Oncotarget Mar 1;7(9):10215-27, 2016. Pub Med Reference

  • Lesniak W, Oskolkov N, Yang X, Pomper MG, Nimmagadda S*, McMahon MT*.  Salicylic Acid Conjugated Dendrimers Are a Tunable, High Performance CEST MRI Nanoplatform. Nano Lett. Apr 13;16(4):2248-53, 2016.  Pub Med Reference

  • Behnam Azad B, Chatterjee S, Poierier JT, Lisok A, Lesniak W, Pullambhatla M, Luker G, Pomper MG, Nimmagadda S.  Targeted Imaging of the Atypical Chemokine Receptor 3 (ACKR3/CXCR7) in Human Cancer Xenografts. J Nucl Med. Jun;57(6):981-8, 2016. Pub Med Reference

  • Gniadek T, Li QK, Tully E, Chatterjee S, Nimmagadda S, Gabrielson E.  Heterogeneous expression of PD-L1 in non-small cell lung cancer: implications for assessment by small biopsy. Mod Pathol. 2017 Jan 6. doi: 10.1038/modpathol.2016.213 [Epub ahead of print]. Pub Med Reference

  • Chatterjee S, Lesniak W, Miller MS, Lisok A, Wharram B, Gabrielson M, Pomper MG, Gabelli SG, Nimmagadda S.  Rapid detection of tumor PD-L1 expression in tumors with PET using a highly specific peptide. Biochem Biophys Res Commun. Jan 29;483(1):258-263. 2017.  Pub Med Reference


Other graduate programs in which Dr. Nimmagadda participates:

  • None