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Matthew M. Ippolito

Richard Ambinder 

Department Affiliation: Primary: Medicine, Division of Clinical Pharmacology; Secondary: Pharmacology and Molecular Sciences and W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health (Malaria Research Institute); Joint: Medicine, Division of Infectious Diseases
Degree: M.D., The Geisel School of Medicine at Dartmouth
Rank: Assistant Professor
Telephone Number: 443-287-4809
Fax Number: 410-502-7029
E-mail address:
School of Medicine Address: Osler 503, 600 N. Wolfe Street, Baltimore, MD 21287


Chemotherapeutics for malaria control and elimination

Research focuses on antimalarial drug PK/PD in the context of malaria control and elimination, and malaria epidemiology in high-transmission settings recalcitrant to current control measures. Emphasis is on field-based Phase II/III trials of antimalarials, clinical approaches to lower malaria mortality in resource-limited areas, and PK drug interactions of antimalarial agents with other anti-infectives and with the gut microbiome.

Representative Publications:

  • Ippolito, M., Johnson, J., Mullin, C., Mallow, C., Morgan, N., Wallender, E., Li, T., Rosenthal, P.J. The relative effects of artemether-lumefantrine and non-artemisinin antimalarials on gametocyte carriage and transmission of Plasmodium falciparum: a systematic review and meta-analysis. Clinical Infectious Diseases 2017;65:486-494.  Pub Med Reference
  • Bakshi, R., Tatham, L., Savage, A., Tripathi, A., Mlambo, G., Ippolito, M., Nenortas, B., Rannard, S., Owen, A., Shapiro, T.A. Long-acting injectable atovaquone nanomedicines for malaria prophylaxis. Nature Communications 2018;9(1):315.  Pub Med Reference 
  • Ippolito, M., Huang, L., Siame, M., Thuma, P., Shapiro, T.A., Aweeka, F.T. Semi-quantitative measurement of the antimalarial lumefantrine from untreated dried blood spots using LC-MS/MS. Journal of Pharmaceutical and Biomedical Analysis 2018;155:241-246. Pub Med Reference   
  • Ippolito, M., Jacobson, J.M., Lederman, M.M., Winterberg, M., Tarning, J., Shapiro, T.A., Flexner, C. Effect of antiretroviral therapies on plasma concentrations of chloroquine. Clinical Infectious Diseases 2018 Oct 30;67(10):1617-1620. Pub Med Reference
  • Ippolito, M., Kamavu, L., Kabuya, J., Tente, C., Wapachole, M., Chileshe, E., Thuma, P., Muleba, M., Chaponda, M., Mulenga, M., Moss, W.J. Risk factors for mortality in children hospitalized with severe malaria in northern Zambia: a retrospective case-control study. American Journal of Tropical Medicine and Hygiene 2018 Jun;98(6):1699-1704.  Pub Med Reference
  • Ippolito, M., Denny, J.E., Langelier, C., Sears, C.L., Schmidt, N.W. Malaria and the microbiome: a systematic review. Clinical Infectious Diseases 2018 Nov 28;67(12):1831-1839. Pub Med Reference



Other graduate programs in which Dr. Ippolito participates:  None