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Ling He

James C. Barrow
Department Affiliation: Primary: Pediatrics/Divisions of Metabolism and Endocrinology;
Secondary: Pharmacology and Molecular Sciences;
Degree: M.D., Third Military Medical University, Chongqin, China; Ph.D., University of Arkansas for Medical Sciences
Rank: Associate Professor
Telephone Number: 410-502-5765
Fax Number: 410-502-5779
E-mail address:
School of Medicine Address: CMSC 10-113, 600 N. Wolfe Street, Baltimore, MD  21287

Coactivators regulate metabolism and mitochondrial function.

My laboratory focuses on the studies: 1) mechanisms of metformin action and AMPK's role in regulating glucose metabolism and mitochondrial function; 2) how the change of intestinal microbiota composition and co-activator CBP and P300’s activity leads to the development of fatty liver.


Representative Publications:  

  • Wang, Y., An, H., Liu, T., Qin, C., Sesaki, H., Guo, S., Radovick, S., Hussain, M., Maheshwari, A., Wondisford, F.E., O'Rourke, B., He, L. Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK. Cell Reports 29(6):1511-1523, 2019. Pub Med Reference
  • Cao, J., Peng, J., An, H., He, Q., Boronina, T., Guo, S., White, M.F., Cole, P.A., He, L. Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity. Nature Communications 8(1):131, 2017. Pub Med Reference
  • He, L., Wondisford, F.E. Metformin action: concentrations matter. Cell Metabolism  21: 159-162, 2015.  Pub Med Reference
  • He, L., Sabet, A., Miller. R., Djedjos, S., Sun, X., Hussain, M., Radovick, S., Wondisford, F.E. Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein (CBP). Cell 137: 635-646, 2009.  Pub Med Reference
  • He, L., Simmen, F.A., Mehendale, H.M., Ronis, M.J., Bader, T.M. Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation. J. Biol. Chem.  281: 11126-11134, 2006.  Pub Med Reference


Other graduate programs in which Dr. He participates:  None