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Ling He

James C. Barrow
Department Affiliation: Primary: Pediatrics/Divisions of Metabolism and Endocrinology;
Secondary: Pharmacology and Molecular Sciences;
Degree: M.D., Third Military Medical University, Chongqin, China; Ph.D., University of Arkansas for Medical Sciences
Rank: Associate Professor
Telephone Number: 410-502-5765
Fax Number: 410-502-5779
E-mail address: heling@jhmi.edu
School of Medicine Address: CMSC 10-113, 600 N. Wolfe Street, Baltimore, MD  21287

Regulations of glucose and lipid metabolism by co-activators and metformin.

My research focuses on the study of physiological roles co-activator CBP and P300 in regulating glucose production and lipogenesis in the liver, and seeks to uncover the mechanisms​ underlying the development of insulin resistance and non-alcoholic fatty liver disease.

Dr. He's laboratory also aims to define the mechanisms underlying the beneficial effects of metformin (first-line antidiabetic agent), such as, amelioration of hyperglycemia in type 2 diabetes.

 

Representative Publications:  

  • He, L., Simmen, F.A., Mehendale, H.M., Ronis, M.J., Bader, T.M. Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation. J. Biol. Chem.  281: 11126-11134, 2006.  Pub Med Reference
     
  • He, L., Sabet, A., Miller. R., Djedjos, S., Sun, X., Hussain, M., Radovick, S., Wondisford, F.E. Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein (CBP). Cell 137: 635-646, 2009.  Pub Med Reference
     
  • Wang, J.,Gallagher, D., DeVito, L.M., Cancino, G.I., Tsui, D., He, L., Keller, G.M., Frankland, P.W., Kaplan, D.R., Miller, F.D. Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 11: 23-35, 2012.  Pub Med Reference    
     
  • Cao, J., Meng, S., Chang, E., Beckwith-Fickas, K., Xiong, L., Cole, B., Radovick, S., Wondisford, F.E., He, L. Low concentrations of metformin suppress glucose production in hepatocytes through AMPK. J. Biol. Chem. 289: 20435-20446, 2014. Paper of the Week (JBC).  Pub Med Reference
     
  • He, L., Wondisford, F.E. Metformin action: concentrations matter. Cell Metabolism  21: 159-162, 2015.  Pub Med Reference
     
  • Meng, S., Cao, J., He, Q., Xiong, L., Chang, E., Radovick, S., Wondisford, F.E., He, L. Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex. J. Biol. Chem.  290: 3793-3802, 2015.  Pub Med Reference 
     

 




Other graduate programs in which Dr. He participates:  None