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Philip A. Cole


Department Affiliation: Pharmacology
Degree: M.D., Ph.D., Johns Hopkins University
Rank: Adjunct Professor
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E-mail address:
Address: Departments of Medicine and Biological Chemistry and Molecular Pharmacology
Harvard Medical School
Division of Genetics, Brigham and Women's Hospital
Room 168C NRB
77 Ave. Louis Pasteur
Boston, MA 02115


Click here to view Dr. Cole's web page at Harvard University.


Chemical and biochemical approaches in the study of signal transduction, gene regulation, and metabolism.

Our lab studies the chemical biology of protein post-translational modification and regulation.  We study the structure, function, and regulation of protein kinases and protein phosphatases by phosphorylation, acetylation, and glycosylation.  In this regard, we have developed a series of technologies including expressed protein ligation, chemical rescue of mutant enzymes, and bisubstrate analog inhibitors that we apply to the analysis of signaling proteins that help clarify substrate selectivity, activation state, and function.  Our lab also studies histone acetyltransferases and demethylases and how they contribute to the regulation of gene expression and signaling.  We have designed a series of selective inhibitors of these enzymes as tools for pharmacologic research. We employ and develop novel protein chemistry and proteomics methods including mass spectrometry to analyze the function of signaling enzymes on a broad scale.  In addition, we are studying the mechanism and function of acyltransferases involved in circadian rhythm and metabolism using chemical biology strategies.


Hopkins Ph.D. Students

Hanjie Jiang
Ph.D. Student in the Pharmacology Graduate Program at Johns Hopkins School of Medicine
Antonieta L. Salguero
Ph.D. Student in the Chemistry-Biology Interface Program at Johns Hopkins University

Other graduate programs in which Dr. Cole participates:

BCMB Program
Chemistry-Biology Interface Program (CBI)
Program in Molecular Biophysics