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Training Program Faculty
Our training faculty are made up of primary faculty in Pharmacology and Molecular Sciences as well as faculty from a variety of other departments at Johns Hopkins who have research interests in (among others) oncology, virology, immunology, chemistry, chemical biology, and clinical pharmacology.
James C. Barrow, Ph.D., Associate Professor
Drug discovery for disorders of neurodevelopment.
Gregory V. Carr, Ph.D., Assistant Professor
Preclinical models of neurological and psychiatric disorders.
Jun O. Liu, Ph.D., Professor
Chemical biology and molecular biology; use of small molecules as probes to elucidate mechanisms of signal transduction; angiogenesis and cell proliferation.
Caren L. Freel Meyers, Ph.D., Associate Professor
Organic and medicinal chemistry, chemical biology: drug delivery; study of non-mammalian isoprenoid biosynthesis; development of potential therapeutic agents for cancer and infectious disease.
Ronald L. Schnaar, Ph.D., Professor
Cell interactions in the nervous system.
James T. Stivers, Ph.D., Professor and Interim Director
Structural and Chemical Biology of Uracil Metabolism and Applications to Cancer Therapy, Innate and Adaptive Immunity.
Sean D. Taverna, Ph.D., Associate Professor
Histone and chromatin modifications, epigenetics and gene function, identification of histone binding modules, and small RNA directed gene silencing.
Huijun Wei, Ph.D., Assistant Professor
Identifying and validating drug targets for the treatment of neurodevelopmental disorders.
Heng Zhu, Ph.D., Professor
Signal Transduction; protein network; host-pathogen interaction; biomarker identification.
Other Training Program Faculty
Richard F. Ambinder, M.D., Ph.D., Professor
Virology and human cancer; antiviral therapy; antitumor therapy; lymphoma pathogenesis and treatment; immunological approaches to virus-associated malignancies.
L. Mario Amzel, Ph.D., Professor
3-D structure of proteins: immunoglobulins and other binding proteins; ATP synthase; monoxygenases and dioxygenases quinone reductase.
James M. Berger, Ph.D., Professor (Secondary)
Structural and catalytic mechanisms of nucleic-acid machines and assemblies; control of DNA replication and chromosome superstructure; small-molecule and biological regulatory mechanisms.
Namandje N. Bumpus, Ph.D., Associate Professor (Secondary)
Drug Metabolism and preclinical drug development; small molecule mass spectrometry; targeted metabolomics; antiviral drug-induced toxicity; modulation of cellular signaling pathways by reactive metabolites.
Ted M. Dawson, M.D., Ph.D., Professor
Molecular and cellular signals controlling neurodegeneration, neuronal survival and cell death.
Samuel R. Denmeade, M.D., Professor
Targeted therapies for cancer; prodrugs; proteases; peptide libraries.
Kelly E. Dooley, M.D., Ph.D., Associate Professor (Secondary)
Clinical pharmacology of anti-infective agents; Evaluation of new drug regimens for the treatment of tuberculosis and co-treatment of TB and HIV.
Laura M. Ensign, Ph.D., Associate Professor (Secondary)
Nanomedicine for drug delivery.
Jed W. Fahey, Sc.D., Assistant Professor (Secondary)
Phytochemistry/nutrition-based prevention of chronic disease.
Charles W. Flexner, M.D., Professor (Secondary)
Basic and clinical pharmacology of antiretroviral drugs; HIV protease inhibitors and entry inhibitors.
Marc M. Greenberg, Ph.D., Professor
Chemical and biochemical approaches to the study of DNA damage and repair, and their applications.
Justin Hanes, Ph.D., Professor (Secondary)
Nanotechnology for Drug and Nucleic Acid Delivery.
J. Marie Hardwick, Ph.D.,Professor (Joint)
Molecular mechanisms of programmed cell death.
Ling He, M.D., Ph.D., Assistant Professor (Secondary)
Regulations of glucose and lipid metabolism by co-activators and metformin.
Craig W. Hendrix, M.D., Professor (Secondary)
Anti-infective drugs; chemoprevention of infectious diseases.
Richard L. Huganir, Ph.D., Professor
Molecular mechanisms in the regulation of synaptic plasticity.
Takanari Inoue, Ph.D., Professor (Secondary)
Synthetic Cell Biology: Total synthesis of cellular functions such as neutrophil chemotaxis and ciliary mechano-sensation
John T. Isaacs, Ph.D., Professor
Anti-cancer drug development; Normal and malignant stem cell biology.
William B. Isaacs, Ph.D., Professor
Understanding the molecular genetic events responsible for initiation and progression of prostate cancer, with particular interest in inherited susceptibility to prostate cancer.
Elizabeth M. Jaffee, M.D., Professor
Analysis of antitumor immune responses against human tumors; identification of the targets of tumor-specific cytotoxic T cells.
David A. Kass, M.D., Professor (Secondary)
Molecular physiology of myocardial disease.
Kenneth W. Kinzler, Ph.D., Professor
Molecular genetics of cancer, translational cancer research.
Mark Levis, M.D., Ph.D., Associate Professor
Targeting the FLT3 signaling pathway as a treatment for acute leukemia.
William G. Nelson, M.D., Ph.D., Professor (Secondary)
Molecular mechanisms of prostatic carcinogenesis; epigenetic alterations in cancer; new approaches to prostate cancer prevention and treatment.
Sridhar Nimmagadda, Ph.D., Associate Professor (Secondary)
Chemokine receptor biology and molecular imaging applications in drug development.
Kenneth J. Pienta, M.D., Professor (Secondary)
The ecology of cancer, tumor microenvironment, metastasis, biomarker development, novel therapeutic development.
Martin G. Pomper, M.D., Ph.D., Professor (Secondary)
In Vivo molecular and cellular imaging; radiopharmaceutical development; targeted cancer imaging and therapy; molecular brain imaging.
Jonathan D. Powell, M.D., Ph.D., Professor (Secondary)
Mechanisms of T cell activation and tolerance.
Stuart C. Ray, M.D., Professor
Computational immunovirology of chronic viral hepatitis.
Douglas N. Robinson, Ph.D., Professor (Secondary)
Understanding cytokinesis and cell shape control.
Christopher A. Ross, M.D., Ph.D., Professor (Secondary)
Theresa A. Shapiro, M.D., Ph.D., Professor (Secondary)
Clinical pharmacology; molecular mechanisms of antiparasitic drug action; effects of topoisomerase inhibitors on DNA of trypanosomes; structure-activity of synthetic antimalarial trioxanes.
Robert F. Siliciano, M.D., Ph.D., Professor (Secondary)
HIV latency, evolution, and persistence; HIV treatment and drug resistance; pharmacology of HIV drugs.
Solomon H. Snyder, M.D., Professor (Secondary)
Molecular basis of neural signal transduction.
Saraswati Sukumar, Ph.D., Professor
Molecular alterations in breast cancer.
Craig A. Townsend, Ph.D., Professor
Organic and bioorganic chemistry: biosynthesis of natural products and biomimetic synthesis; elucidation of protein function; molecular biology of secondary metabolism and engineering of biosynthetic systems to practical ends; study of the role and inhibition of fatty acid synthesis in human cancer, tuberculosis, and obesity.
Bert Vogelstein, M.D., Professor
Molecular genetics of human cancer.
Srinivasan Yegnasubramanian, M.D., Ph.D., Associate Professor
Understanding and exploiting alterations in the cancer genome and epigenome for development of biomarkers and therapeutics.
Other Associated Faculty
J. Thomas August, M.D., Professor (Primary Appointment)
Genetic immunotherapy of infectious diseases and cancer by targeting DNA encoded antigen chimeras to MHC II; MHC II antigen presentation; development of DNA vaccines; immune tolerance.
Philip A. Cole M.D., Ph.D., Professor (Adjunct)
Chemical and biochemical approaches in the study of signal transduction, circadian rhythm, and gene regulation.
Albena Dinkova-Kostova, Ph.D., Associate Professor (Part-time)
Protection against cancer mechanisms and strategies; structure-activity relation of protective agents; inflammation and cancer; skin cancer prevention.
Wade Gibson, Ph.D., Professor Emeritus (Primary Appointment)
Herpesvirus proteins: studies of their expression, structure, and function using genetic, biochemical, and immunological approaches.
Gary S. Hayward, Ph.D., Professor (Secondary Appointment) (Secondary Appointment)
Pathways of herpesvirus gene regulation, latency and pathogenesis; enhancer and silencer elements that modulate gene expression; mechanisms of positive and negative transcriptional regulation; interaction with and targeting to subnuclear domains by viral regulatory proteins; molecular piracy and promotion of angiogenesis by Kaposi's sarcoma herpesvirus; virus evasion of interferon-mediated innate immunity; virus evolution and virus hunting.
S. Diane Hayward, Ph.D., Professor Emeritus (Secondary Appointment)
Epstein-Barr virus and Kaposi's sarcoma virus; viral latency and tumorigenesis; mechanisms of virus-induced cell proliferation; viral mediated epigenetic modification of cell gene expression; notch and wnt pathways.
Thomas W. Kensler, Ph.D., Professor (Affiliated, Joint Appointment)
Molecular mechanisms of chemical carcinogenesis; Nrf2 signalling; cancer chemoprevention.
Brent Petty, M.D., Associate Professor (Secondary Appointment)
Antimicrobial chemotherapy; hospital-based medical practices; internal medicine collaboration with ophthalmologic clinical trials.
Mark A Schenerman, Professor (Adjunct)
Development of biopharmaceuticals to address infectious disease and cancer.
Paul Talalay, M.D., Professor (Primary Appointment)
Molecular mechanisms involved in chemoprotection against mutagens and carcinogens.
Johannes N. van den Anker, M.D., Ph.D., Professor (Adjunct)
Department of Pediatrics
The George Washington University School of Medicine and Health Sciences
Amina S. Woods, Ph.D., Professor (Adjunct)
Structural Biology Unit, Cellular Neurobiology
NIH, NIDA IRP
Jin Zhang, Ph.D., Professor (Adjunct)
Department of Pharmacology
University of California, San Diego