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Recent Publications

David  Hackam and his team have authored numerous papers for publication in a wide range of national and international medical journals, reflecting the importance of their work in the research lab. Below are some of the most significant recent articles.

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Toll-Like Receptor 4 Regulates Platelet Function and Contributes to Coagulation Abnormality and Organ Injury in Hemorrhagic Shock and Resuscitation. Ding N, Chen G, Hoffman R, Loughran PA, Sodhi CP, Hackam DJ, Billiar TR, Neal MD. Circ Cardiovasc Genet. 2014 Oct;7(5):615-624. Epub 2014 Jul 21.

Evidence-based feeding strategies before and after the development of necrotizing enterocolitis. Good M, Sodhi CP, Hackam DJ. Expert Rev Clin Immunol. 2014 Jul;10(7):875-84. doi: 10.1586/1744666X.2014.913481. Epub 2014 Jun 5.

A novel scoring system to predict the development of necrotizing enterocolitis totalis in premature infants. Sho S, Neal MD, Sperry J, Hackam DJ. J Pediatr Surg. 2014 Jul;49(7):1053-6. doi: 10.1016/j.jpedsurg.2013.10.023. Epub 2013 Nov 7.

Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges. Lu P, Sodhi CP, Jia H, Shaffiey S, Good M, Branca MF, Hackam DJ. Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1;306(11):G917-28. doi: 10.1152/ajpgi.00422.2013. Epub 2014 Apr 24.

Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9. Good M, Sodhi CP, Ozolek JA, Buck RH, Goehring KC, Thomas DL, Vikram A, Bibby K, Morowitz MJ, Firek B, Lu P, Hackam DJ. Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1;306(11):G1021-32. doi: 10.1152/ajpgi.00452.2013. Epub 2014 Apr 17.

Genetic deletion of toll-like receptor 4 on platelets attenuates experimental pulmonary hypertension. Bauer EM, Chanthaphavong RS, Sodhi CP, Hackam DJ, Billiar TR, Bauer PM. Circ Res. 2014 May 9;114(10):1596-600. doi: 10.1161/CIRCRESAHA.114.303662. Epub 2014 Mar 17.

Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis. Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T Jr, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen K, Kaser A, Blumberg R, Hackam DJ. J Biol Chem. 2014 Apr 4;289(14):9584-99. doi: 10.1074/jbc.M113.526517. Epub 2014 Feb 11.

Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis. Lu P, Sodhi CP, Hackam DJ. Pathophysiology. 2014 Feb;21(1):81-93. doi: 10.1016/j.pathophys.2013.11.007. Epub 2013 Dec 22.

Mucosa-associated bacterial diversity in necrotizing enterocolitis. Brower-Sinning R, Zhong D, Good M, Firek B, Baker R, Sodhi CP, Hackam DJ, Morowitz MJ. PLoS One. 2014 Sep 9;9(9):e105046. doi: 10.1371/journal.pone.0105046. eCollection 2014.


Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice. Nace GW, Huang H, Klune JR, Eid RE, Rosborough BR, Korff S, Li S, Shapiro RA, Stolz DB, Sodhi CP, Hackam DJ, Geller DA, Billiar TR, Tsung A. Hepatology. 2013 Jul;58(1):374-87. doi: 10.1002/hep.26346. Epub 2013 May 27.

Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. Neal MD, Jia H, Eyer B, Good M, Guerriero CJ, Sodhi CP, Afrazi A, Prindle T Jr, Ma C, Branca M, Ozolek J, Brodsky JL, Wipf P, Hackam DJ. PLoS One. 2013 Jun 12;8(6):e65779. doi: 10.1371/journal.pone.0065779. Print 2013.

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling. Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, Binion DG, Gladwin MT, Hackam DJ. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9451-6. doi: 10.1073/pnas.1219997110. Epub 2013 May 6.

Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Hackam DJ, Good M, Sodhi CP. Semin Pediatr Surg. 2013 May;22(2):76-82. doi: 10.1053/j.sempedsurg.2013.01.003. Review.

Management of premature infants. Preface. Ford HR, Hackam DJ. Semin Pediatr Surg. 2013 May;22(2):67-8. doi: 10.1053/j.sempedsurg.2013.01.001. No abstract available.

A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. Neal MD, Sodhi CP, Dyer M, Craig BT, Good M, Jia H, Yazji I, Afrazi A, Richardson WM, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca MF, Ozolek J, Hackam DJ. J Immunol. 2013 Apr 1;190(7):3541-51. doi: 10.4049/jimmunol.1202264. Epub 2013 Mar 1.

Innate immune signaling in the pathogenesis of necrotizing enterocolitis. Hackam DJ, Afrazi A, Good M, Sodhi CP. Clin Dev Immunol. 2013;2013:475415. doi: 10.1155/2013/475415. Epub 2013 May 23. Review.


Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis. Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T Jr, Grant Z, Ozolek J, Hackam DJ. J Biol Chem. 2012 Oct 26;287(44):37296-308. doi: 10.1074/jbc.M112.375881. Epub 2012 Sep 6.

WNT1-inducible signaling pathway protein 1 contributes to ventilator-induced lung injury. Li HH, Li Q, Liu P, Liu Y, Li J, Wasserloos K, Chao W, You M, Oury TD, Chhinder S, Hackam DJ, Billiar TR, Leikauf GD, Pitt BR, Zhang LM. Am J Respir Cell Mol Biol. 2012 Oct;47(4):528-35. doi: 10.1165/rcmb.2012-0127OC. Epub 2012 Jun 14.

Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M, Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ. Gastroenterology. 2012 Sep;143(3):708-18.e1-5. doi: 10.1053/j.gastro.2012.05.053. Epub 2012 Jul 13.

Guts, germs and glucose: understanding the effects of prematurity on the interaction between bacteria and nutrient absorption across the intestine. Hackam DJ. Br J Nutr. 2012 Aug;108(4):571-3. doi: 10.1017/S0007114511006416. Epub 2011 Dec 5. No abstract available.

Cloacal exstrophy variant with intravesical phallus: further description of anatomy and implications for gender reassignment. Tomaszewski JJ, Smaldone MC, Cannon GM, Schneck FX, Hackam DJ, Docimo SG. J Pediatr Urol. 2012 Aug;8(4):426-30. doi: 10.1016/j.jpurol.2011.09.003. Epub 2011 Nov 6. Review.

Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium. Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF, Ma C, Prindle T, Grant Z, Shah S, Slagle D 2nd, Paredes J, Ozolek J, Gittes GK, Hackam DJ. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11330-5. doi: 10.1073/pnas.1200856109. Epub 2012 Jun 25.

Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. Afrazi A, Sodhi CP, Good M, Jia H, Siggers R, Yazji I, Ma C, Neal MD, Prindle T, Grant ZS, Branca MF, Ozolek J, Chang EB, Hackam DJ. J Immunol. 2012 May 1;188(9):4543-57. doi: 10.4049/jimmunol.1103114. Epub 2012 Mar 28.

Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis. Yi H, Patel AK, Sodhi CP, Hackam DJ, Hackam AS. PLoS One. 2012;7(5):e36560. doi: 10.1371/journal.pone.0036560. Epub 2012 May 17.


Toll-like receptor-4 inhibits enterocyte proliferation via impaired beta-catenin signaling in necrotizing enterocolitis. Sodhi CP, Shi XH, Richardson WM, Grant ZS, Shapiro RA, Prindle T Jr, Branca M, Russo A, Gribar SC, Ma C, Hackam DJ. Gastroenterology. 2010 Jan;138(1):185-96. doi: 10.1053/j.gastro.2009.09.045. Epub 2009 Sep 26.


Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. Gribar SC, Sodhi CP, Richardson WM, Anand RJ, Gittes GK, Branca MF, Jakub A, Shi XH, Shah S, Ozolek JA, Hackam DJ. J Immunol. 2009 Jan 1;182(1):636-46.


A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. Leaphart CL, Cavallo J, Gribar SC, Cetin S, Li J, Branca MF, Dubowski TD, Sodhi CP, Hackam DJ. J Immunol. 2007 Oct 1;179(7):4808-20.