Zhou Lab

The overall goal of our research is to understand the molecular mechanisms underlying development of the mammalian nervous system. Specifically, we are interested in understanding how neurons generate their complex morphology and form proper circuitries during development, and how neurons regenerate to restore connections after brain or spinal cord injuries.

Research

Molecular Mechanisms of Neuronal Morphogenesis During Development and Regeneration

The overall goal of our research is to understand the molecular mechanisms underlying development of the mammalian nervous system. Specifically, we are interested in understanding how neurons generate their complex morphology and form proper circuitries during development and how neurons regenerate to restore connections after brain or spinal cord injuries.

Current Projects

Members

Mei Zhang, Ph.D. (postdoctoral fellow)

Jingjing Jiang, M.D., Ph.D. (visiting scholar)

Liuwang Zeng, M.D., Ph.D. (visiting scholar)

Past Members

Trinity Perry (lab technician, 2006–2007)

Wen-Lin Xu (postdoctoral fellow, 2007–2009)

Sarah Skelton (research fellow, 2007–2009)

Yun-Tai Kim (postdoctoral fellow, 2011)

Philip Rusty Nicovich (postdoctoral fellow, 2010–2012)

Eun-Mi Hur (postdoctoral fellow, 2006–2012)

Ruiying Wang, M.D. (visiting scholar, 2012–2013)

Yiwen Hu, M.D. (visiting graduate student, 2013–2013)

Boyin Zhang, M.D. (visiting graduate student, 2012–2013)

Yu Guo, M.D. (visiting scholar, 2013–2014)

Zhongxian Jiao, Ph.D. (research specialist, 2011–2014)

Changmei Liu, Ph.D. (postdoctoral fellow, 2011–2014)

Jian Yuan (visiting student, 2014–2014)

Saijilafu, Ph.D. (research associate, 2007–2014)

Publications

Qian C, Dong B, Wang XY, Zhou FQ. In Vivo Glial Trans-differentiation for Neuronal Replacement and Functional Recovery in Central Nervous System. FEBS J. 2020 Dec 22. doi: 10.1111/febs.15681

Yang SG, Li CP, Peng XQ, Teng ZQ, Liu CM, Zhou FQ. Strategies to Promote Long-Distance Optic Nerve Regeneration. Front Cell Neurosci. 2020 May 14;14:119. doi: 10.3389/fncel.2020.00119.

Qian C, Zhou FQ. Updates and challenges of axon regeneration in the mammalian central nervous system. J Mol Cell Biol. 2020 May 29:mjaa026. doi: 10.1093/jmcb/mjaa026.

Nathan FM, Ohtake Y, Wang S, Jiang X, Sami A, Guo H, Zhou FQ, Li S. Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury. Mol Ther. 2020 Aug 5;28(8):1902-1917. doi: 10.1016/j.ymthe.2020.04.010.

Wang XW, Yang SG, Zhang C, Hu MW, Qian J, Ma JJ, Zhang Y, Yang BB, Weng YL, Ming GL, Kosanam AR, Saijilafu, Zhou FQ. Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration. Cell Rep. 2020 Apr 21;31(3):107537. doi: 10.1016/j.celrep.2020.107537.

View more publications.

Contact Us

The Johns Hopkins University School of Medicine
The John G. Rangos Sr. Building, Room 291
855 N. Wolfe. St.
Baltimore, MD 21205
Office: 443-287-5649
Lab: 410-502-6416
Email: [email protected]