Our orthopaedic research division and its faculty members are recognized internationally as leading innovators in musculoskeletal science and training. Our investigators conduct basic, translational and clinical research in topics that represent the great diversity of problems that impact the musculoskeletal system. Focus areas include integrative musculoskeletal biology, stem cells and regenerative medicine, skeletal neurobiology, bone metastasis and clinical outcomes.
Research in the Clemens Lab focuses on identification of the cellular and molecular mechanisms that mediate bone formation and repair. Currently, we are studying the role of sensory nerves in bone and the coupling of bone cell metabolic activity to the sensory nerves' development and function.
The skeleton is one of the most important structures in our bodies. Bones allow us to stand, walk and move from one place to another, and they serve as protectors of our vital organs. With aging, our skeleton both loses its bone mineral and the structure (micro-architecture). The fine trabecular bone is organized into plates and rods, and these structures develop cracks and discontinuity. As we age, bone is lost and its structure compromised. This degradation of our bone structure — osteoporosis — is a global health problem. Thomas Clemens, M.D. is the director of the Clemens lab. He is the Lewis Cass Spencer professor of orthopaedic surgery and the vice chair for research in the Department of... Orthopaedic Surgery at Johns Hopkins. view more
This lab is lead by Drs. Thomas Clemens, Xu Cao and Mei Wan. This lab focuses on researching solutions that will improve the diagnosis and treatments for adult orthopaedic patients with musculoskeletal disorders and conditions.
Malfunction and malformation of blood vessels are associated with a broad range of medical conditions, including cancer, cardiovascular diseases, and neurological disorders. The ultimate goal of the Komatsu lab is to find a way to reverse the process of abnormal vessel formation and restore normal function to these vessels. In cancer, normalization of tumor blood vessels facilitates lymphocyte infiltration, potentiating anti-tumor immunity, and enhances the efficacy of immunotherapies as well as conventional cancer treatments. Normalization of regenerating blood vessels is also necessary for reestablishing blood flow to ischemic hearts and limbs, and preventing blindness caused by diabetic retinopathy or macular degeneration. Komatsu lab’s research is uncovering key molecular pathways important for the normalization of pathological vasculature.
The Spine Outcomes Research Center is a multidisciplinary group committed to improving patient outcomes and applying high-quality and purposeful research to professional practice. The organization values collegial interaction and strong scientific principles.
In the Zhou Lab, the overall goal of our research is to understand the molecular mechanisms underlying development of the mammalian nervous system. Specifically, we are interested in understanding how neurons generate their complex morphology and form proper circuitries during development and how neurons regenerate to restore connections after brain or spinal cord injuries.