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Clinical Research

For a complete list of available clinical trials, search the database at the Johns Hopkins Institute for Clinical and Translational Research. You can search by condition, researcher or doctor’s name.

A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee (PEAK)

Objective: To evaluate an experimental treatment for knee cartilage defects called membrane-induced autologous chondrocyte implantation (MACI).
Principle InvestigatorR. Jay Lee, M.D.
Eligibility Criteria: Children age 11-17 with knee cartilage defects
Contact: Gabrielle Reichard (
Learn more about this study.

A Post-Market, Prospective, Multi-Center, Open-Label, Single Arm Clinical Evaluation of the Integra TitanTM Modular Shoulder System 2.5 for Primary Shoulder Joint Replacement (IRB00169712)

Objective: To evaluate 2-year implant survivorship in subjects who receive the TSS-2.5 when used for primary shoulder arthroplasty.
Principle Investigator: Umasuthan Srikumaran, M.D., M.P.H., M.B.A.
Eligibility Criteria: Candidate for total shoulder arthroplasty
Contact: Sanjana Vattigunta (443-516-1550 or
Learn more about this study.

Post-operative Pain Control Following Shoulder Surgery

Objective: Evaluate overall pain medication consumption following surgical treatment for shoulder pathology
Principle Investigator: Umasuthan Srikumaran, M.D., M.P.H., M.B.A.
Eligibility Criteria: Opioid-naive adults age 18-90 years old planning to undergo surgical treatment for shoulder pathology with Dr. Uma Srikumaran
Contact: Sanjana Vattigunta (443-516-1550 or

OPTIMIZE Low Back Pain

Objective: Improve health care for patients with chronic lower back pain (LBP) and increase the likelihood that patients obtain outcomes that matter most to them
Principle Investigator: Richard Skolasky, Sc.D.
Eligibility Criteria: Adults age 18 - 64 years old, meets NIH Task Force definition of chronic LBP, had a healthcare visit for LBP in the past 90 days and have moderate levels of pain and disability
Contact: Tricia Kirkhart (410-502-4453 or
Learn more about this study.

Dysport® (abobotulinumtoxinA) as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis (AIS)

Objective: To evaluate the combined effect of botulinum toxin A (administered as Dysport®) and bracing in children with adolescent idiopathic scoliosis
Principle InvestigatorPaul D. Sponseller, M.D.
Eligibility Criteria: Diagnosed with AIS, 10 - 16 year old children.
Contact: Vivian Tran and Varun Puvanesarajah (410-955-3136 or

Participants in this study will be compensated.
Learn more about this study.

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