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Promise and Progress - 3D Scans Show whether Treatment is Working

Reprogramming Cancer Cells - The Story of Epigenetics
Issue No. 1

3D Scans Show whether Treatment is Working

Date: July 16, 2014

Society of Interventional Radiology, March 2014

Scientists used 3-D MRI (magnetic resonance imaging) scans to precisely measure living and dying tumor tissue and quickly test whether treatment of liver tumors was working.

The study, directed by Kimmel Cancer Center investigator and interventional radiologist Jean-Francois Geschwind, M.D., was the first to prove that visualizing a tumor in three dimensions allowed accurate assessment of tumor cell death. The researchers believe the scans could be instrumental in evaluating the success of chemoembolization, a treatment in which very high doses of anticancer drugs are injected directly into tumors through the blood vessels that nourish them.  The therapy is used to combat cancers that originate in the liver and cancers that spread to the liver. The researchers say 3-D MRI scans provide rapid confirmation of tumor cell death—or just as importantly, lack of cell death—to help guide treatment decisions.

The research was funded by the French Society of Radiology, Philips Research North American, the Rolf W. Gunther Foundation for Radiology and Radiological Sciences, and the National Institutes of Health’s National Cancer Institute and the National Center for Research Resources grants R01 CA 160771, P30 CA006973, and UL1 RR025005.

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