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Home > News and Publications > JHM Publications > Promise and Progress > Promise & Progress - A Spectrum of Achievements
Promise and Progress - Personalized Prostate Cancer Approach
Promise & Progress - A Spectrum of Achievements
Personalized Prostate Cancer Approach
Date: January 15, 2015
Jun Luo and Emmanuel Antonarakis
New England Journal of Medicine, Sept. 3, 2014
New research findings from the Kimmel Cancer Center and Brady Urological Institute may provide a personalized treatment approach for patients with advanced prostate cancer. The investigators found that prostate tumors that contained a shortened androgen receptor protein known as AR-V7 may not respond to two drugs commonly used to treat prostate cancers that have spread.
The protein can be detected in blood. If these findings are confirmed in larger studies, the investigators say men with detectable blood levels of AR-V7 should avoid enzalutamide and abiraterone in favor of other medicines.
The drugs work well in about 80 percent of prostate cancer patients, and this finding could help identify those most likely to benefit and facilitate improved treatment for the 20 percent who do not benefit. “Until now, we haven’t been able to predict which patients will not respond to these therapies,” says Emmanuel Antonarakis, M.D., assistant professor of oncology. “A blood test could use AR-V7 as a biomarker to predict drug resistance and let us direct patients who test positive for AR-V7 away from futile therapy and toward other types of therapy sooner.”
Antanorakis collaborated with Jun Luo, Ph.D., associate professor of urology, who first identified AR-V7 in his laboratory in 2007.
Research funding was provided by the Prostate Cancer Foundation, the Department of Defense, and the National Institutes of Health’s National Cancer Institute (CA058236, CA006973)
Articles in this Issue
- World's First Protein Catalog
- How Cancer Cells Keep Going When Other Cells Stop
- Mega Analysis Uncovers Prostate Cancer Risk
- Tobacco and Oral Cancer-Causing Infection
- Test for Oral Cancers
- Shortened BMT Treatment Gets the Job Done
- Greenberg Bladder Cancer Institute Awards First Research Grant
- No More Repeat Prostate Biopsies
- How Breast Cancer Spreads
- Tiny "Ship" Delivers Death Command to Brain Cancer
- Human Chemical Detoxifiers
- Cancer-Fighting Bacteria
- Game Theory and Cancer
- Recruiting Cancer Immunity
- Broccoli Sprouts Detoxify Dirty Air
- Personalized Prostate Cancer Approach
- Amen to Miracles