Johns Hopkins scientists are developing new tools to identify and characterize molecular alterations that occur during the formation and progression of ovarian cancers. Recent genomewide analyses have pinpointed specific molecular changes in several new cancer-associated genes, including ARID1A, Rsf-1, SYK, NAC-1 and Notch3. Translational research focuses on early cancer detection using body fluid samples from liquid biopsies and innovative molecular techniques. Researchers are also studying new therapeutic reagents and immunotherapies that target cancer-associated molecules, with the goal of developing new drugs to treat recurrent ovarian cancer.