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Neurology and Neurosurgery

Johns Hopkins Center for the Advancement of HIV Neurotherapeutics

Clinical Research Publications

  1. Improvement in depressive symptoms after antiretroviral therapy initiation in people with HIV in Rakai, Uganda.
    Nakasujja, Noeline; Vecchio, Alyssa C; Saylor, Deanna; Lofgren, Sarah; Nakigozi, Gertrude; Boulware, David R; Kisakye, Alice; Batte, James; Mayanja, Richard; Anok, Aggrey; Reynolds, Steven J; Quinn, Thomas C; Pardo, Carlos A; Kumar, Anupama; Gray, Ronald H; Wawer, Maria J; Sacktor, Ned; Rubin, Leah H. Journal of neurovirology 2021 Aug; 27 (4) 519-530.

  2. Plasma inflammatory biomarkers link to diffusion tensor imaging metrics in virally suppressed HIV-infected individuals.
    Chang, Kevin; Premeaux, Thomas A; Cobigo, Yann; Milanini, Benedetta; Hellmuth, Joanna; Rubin, Leah H; Javandel, Shireen; Allen, Isabel; Ndhlovu, Lishomwa C; Paul, Robert; Valcour, Victor. AIDS (London, England) 2020 02 01; 34 (2) 203-213

  3. The Veterans Aging Cohort Study Index is not associated with HIV-associated neurocognitive disorders in Uganda.
    Awori, Violet; Nakigozi, Gertrude; Kisakye, Alice; Batte, James; Anok, Aggrey; Mayanja, Richard; Nakasujja, Noeline; Robertson, Kevin R; Gray, Ronald H; Wawer, Maria J; Sacktor, Ned; Saylor, Deanna. Journal of neurovirology 2020 04; 26 (2) 252-256.

  4. Starting or Switching to an Integrase Inhibitor-Based Regimen Affects PTSD Symptoms in Women with HIV.
    Kamkwalala, Asante R; Wang, Kunbo; O'Halloran, Jane; Williams, Dionna W; Dastgheyb, Raha; Fitzgerald, Kathryn C; Spence, Amanda B; Maki, Pauline M; Gustafson, Deborah R; Milam, Joel; Sharma, Anjali; Weber, Kathleen M; Adimora, Adaora A; Ofotokun, Igho; Sheth, Anandi N; Lahiri, Cecile D; Fischl, Margaret A; Konkle-Parker, Deborah; Xu, Yanxun; Rubin, Leah H. AIDS and behavior 2021 Jan; 25 (1) 225-236.

  5. Integrase Strand Transfer Inhibitor Start or Switch Impacts Learning in Women With HIV.
    O'Halloran, Jane A; Wang, Kunbo; Spence, Amanda B; Williams, Dionna W; Dastgheyb, Raha; Fitzgerald, Kathryn C; Kamkwalala, Asante R; Maki, Pauline M; Sharma, Anjali; Gustafson, Deborah R; Milam, Joel; Weber, Kathleen M; Adimora, Adaora A; Ofotokun, Igho; Fischl, Margaret A; Konkle-Parker, Deborah; Lahiri, Cecile D; Sheth, Anandi N; Xu, Yanxun; Rubin, Leah H. Journal of acquired immune deficiency syndromes (1999) 2021 04 15; 86 (5) 593-599         

  6. Sex-specific associations between cerebrospinal fluid inflammatory marker levels and cognitive function in antiretroviral treated people living with HIV in rural Uganda.
    Vecchio, Alyssa C; Williams, Dionna W; Xu, Yanxun; Yu, Danyang; Saylor, Deanna; Lofgren, Sarah; O'Toole, Riley; Boulware, David R; Nakasujja, Noeline; Nakigozi, Gertrude; Kisakye, Alice; Batte, James; Mayanja, Richard; Anok, Aggrey; Reynolds, Steven J; Quinn, Thomas C; Gray, Ronald H; Wawer, Maria J; Sacktor, Ned; Rubin, Leah H. Brain, behavior, and immunity 2021 03; 93 111-118.

  7. Utility of the International HIV Dementia Scale for HIV-Associated Neurocognitive Disorder.
    Molinaro, Maria; Sacktor, Ned; Nakigozi, Gertrude; Anok, Aggrey; Batte, James; Kisakye, Alice; Myanja, Richard; Nakasujja, Noeline; Robertson, Kevin R; Gray, Ronald H; Wawer, Maria J; Saylor, Deanna. Journal of acquired immune deficiency syndromes (1999) 2020 03 01; 83 (3) 278-283     

  8. Higher circulating intermediate monocytes are associated with cognitive function in women with HIV.
    Veenhuis, R. T., Williams, D. W., Shirk, E. N., Abreu, C. M., Ferreira, E. A., Coughlin, J. M., Brown, T. T., Maki, P. M., Anastos, K., Berman, J. W., Clements, J. E., & Rubin, L. H. (2021). JCI insight, 6(11), e146215. https://doi.org/10.1172/jci.insight.146215.

  9. Neurocognitive Complications of HIV Infection in Women: Insights from the WIHS Cohort. Rubin LH, Maki PM. Curr Top Behav Neurosci. 2019 Aug 9. doi: 10.1007/7854_2019_101. [Epub ahead of print] PMID: 31396894
  10. Neurocognitive Complications of HIV Infection in Low-Income Countries. Vecchio A, Sacktor N, Saylor D, Robertson K. Curr Top Behav Neurosci. 2019 Jul 12. doi: 10.1007/7854_2019_92. [Epub ahead of print] PMID: 31297744
  11. Heterogeneity in neurocognitive change trajectories among people with HIV starting antiretroviral therapy in Rakai, Uganda. Rubin LH, Saylor D, Nakigozi G, Nakasujja N, Robertson K, Kisakye A, Batte J, Mayanja R, Anok A, Lofgren SM, Boulware DR, Dastgheyb R, Reynolds SJ, Quinn TC, Gray RH, Wawer MJ, Sacktor N. J Neurovirol. 2019 Jun 19. doi: 10.1007/s13365-019-00768-5. [Epub ahead of print]. PMID: 31218522
  12. Elevated Depressive Symptoms Are a Stronger Predictor of Executive Dysfunction in HIV-Infected Women Than in Men. Rubin LH, Springer G, Martin EM, Seaberg EC, Sacktor NC, Levine A, Valcour VG, Young MA, Becker JT, Maki PM. J Acquir Immune Defic Syndr. 2019 Jul 1;81(3):274-283. doi: 10.1097/QAI.0000000000002029. PMID: 30893126
  13. Paroxetine and fluconazole therapy for HIV-associated neurocognitive impairment: results from a double-blind, placebo-controlled trial. Sacktor N, Skolasky RL, Moxley R, Wang S, Mielke MM, Munro C, Steiner J, Nath A, Haughey N, McArthur J. J Neurovirol. 2018 Feb;24(1):16-27. doi: 10.1007/s13365-017-0587-z. Epub 2017 Oct 23. PMID: 29063516
  14. Current Challenges and Solutions in Research and Clinical Care of Older Persons Living with HIV: Findings Presented at the 9th International Workshop on HIV and Aging. Sundermann E, Erlandson KM, Pope CN, Rubtsova A, Montoya JL, Moore A, Marzolini C, O'Brien K, Pahwa S, Payne B, Rubin L, Walmsley S, Haughey N, Montano M, Karris M, Margolick JB, Moore DJ. AIDS Res Hum Retroviruses. 2019 Aug 2. doi: 10.1089/AID.2019.0100. [Epub ahead of print]. PMID: 31373216
  15. Abassi M, Morawski BM, Nakigozi G, Nakasujja N, Kong X, Meya DB, Robertson K, Gray R, Wawer MJ, Sacktor N, Boulware DR. Cerebrospinal fluid biomarkers and HIV-associated neurocognitive disorders in HIV-infected individuals in Rakai, Uganda. J Neurovirol. 2016 Dec 19. [Epub ahead of print] PMID: 27995575.
  16. Lake JE, Popov M, Post WS, Palella FJ, Sacktor N, Miller EN, Brown TT, Becker JT. Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status. J Neurovirol. 2016 Dec 15. [Epub ahead of print]. PMID: 27981440.
  17. Cooley SA, Paul RH, Fennema-Notestine C, Morgan EE, Vaida F, Deng Q, Chen JA, Letendre S, Ellis R, Clifford DB, Marra CM, Collier AC, Gelman BB,McArthur JC, McCutchan JA, Simpson DM, Morgello S, Grant I, Ances BM; CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) Group. Apolipoprotein E ε4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals. J Neurovirol. 2016 Mar 28. [Epub ahead of print] PMID: 27021072. PMCID: PMC5040614.
  18. Hammond ER, Crum RM, Treisman GJ, Mehta SH, Clifford DB, Ellis RJ, Gelman BB, Grant I, Letendre SL, Marra CM, Morgello S, Simpson DM, Mcarthur JC; CHARTER Group. Persistent CSF but not plasma HIV RNA is associated with increased risk of new-onset moderate-to-severe depressive symptoms; a prospective cohort study. J Neurovirol. 2016 Aug;22(4):479-87. doi: 10.1007/s13365-015-0416-1. Epub 2016 Jan 4. PMID: 26727907. PMCID: PMC4925276.
  19. Kallianpur AR, Wang Q, Jia P, Hulgan T, Zhao Z, Letendre SL, Ellis RJ, Heaton RK, Franklin DR, BarnholtzSloan J, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Grant I; CHARTER Study Group. Anemia and Red Blood Cell Indices Predict HIVAssociated Neurocognitive Impairment in the Highly Active Antiretroviral Therapy Era. J Infect Dis. 2016 Apr 1;213(7):1065-73. doi: 10.1093/infdis/jiv754. Epub 2015 Dec 21. PMID: 26690344. PMCID: PMC4779306.
  20. McArthur JC, Nath A. In memoriam: Richard T. Johnson, 1931-2015. Ann Neurol. 2016 Jan;79(1):9-10. doi: 10.1002/ana.24576. No abstract available. PMID: 26660084.
  21. Ma Q, Vaida F, Wong J, Sanders CA, Kao YT, Croteau D, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, Morgello S, Simpson DM, Heaton RK, Grant I, Letendre SL; CHARTER Group. Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients. J Neurovirol. 2016 Apr;22(2):170-8. doi: 10.1007/s13365-015-0382-7. Epub 2015 Sep 25. PMID: 26407716. PMCID: PMC4783211.
  22. Obermeit LC, Beltran J, Casaletto KB, Franklin DR, Letendre S, Ellis R, Fennema-Notestine C, Vaida F, Collier AC, Marra CM, Clifford D, Gelman B, Sacktor N, Morgello S, Simpson D, McCutchan JA, Grant I, Heaton RK; CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) Group. Evaluating the accuracy of self-report for the diagnosis of HIV-associated neurocognitive disorder (HAND): defining "symptomatic" versus "asymptomatic" HAND. J Neurovirol. 2016 Aug 24. [Epub ahead of print] PubMed PMID: 27557777. PMCID: PMC5325815.
  23. Buch S, Chivero ET, Hoare J, Jumare J, Nakasujja N, Mudenda V, Paul R, Kanmogne GD, Sacktor N, Wood C, Royal W, Joseph J. Proceedings from the NIMH symposium on "NeuroAIDS in Africa: neurological and neuropsychiatric complications of HIV". J Neurovirol. 2016 Jul 29. [Epub ahead of print] PubMed PMID: 27473196. PMCID: PMC5055435.
  24. Saylor D, Dickens AM, Sacktor N, Haughey N, Slusher B, Pletnikov M, Mankowski JL, Brown A, Volsky DJ, McArthur JC. HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment. Nat Rev Neurol. 2016 May;12(5):309. doi: 10.1038/nrneurol.2016.53. Epub 2016 Apr 15. PubMed PMID: 27080521. PMCID: PMC4937456.
  25. Joska JA, Witten J, Thomas KG, Robertson C, Casson-Crook M, Roosa H, Creighton J, Lyons J, McArthur J, Sacktor NC. A Comparison of Five Brief Screening Tools for HIV-Associated Neurocognitive Disorders in the USA and South Africa. AIDS Behav. 2016 Aug;20(8):1621-31. doi: 10.1007/s10461-016-1316-y. PubMed PMID: 26860536.
  26. Robertson K, Jiang H, Evans SR, Marra CM, Berzins B, Hakim J, Sacktor N, Silva MT, Campbell TB, Nair A, Schouten J; 5271 study team, Kumwenda J, Supparatpinyo K, Tripathy S, Kumarasamy N, la Rosa A, Montano S, Mwafongo A, Firnhaber C, Sanne I, Naini L, Amod F, Walawander A; AIDS Clinical Trials Group. International neurocognitive normative study: neurocognitive comparison data in diverse resourcelimited settings: AIDS Clinical Trials Group A5271. J Neurovirol. 2016 Aug;22(4):472-8. doi: 10.1007/s13365-015-0415-2. Epub 2016 Jan 5. PubMed PMID: 26733457; PubMed Central PMCID: PMC4981921.
  27. Sacktor N, Skolasky RL, Seaberg E, Munro C, Becker JT, Martin E, Ragin A, Levine A, Miller E. Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study. Neurology. 2016 Jan 26;86(4):334-40. doi: 10.1212/WNL.0000000000002277. Epub 2015 Dec 30. PubMed PMID: 26718568; PubMed Central PMCID: PMC4776086.
  28. Fazeli PL, Moore DJ, Franklin DR, Umlauf A, Heaton RK, Collier AC, Marra CM, Clifford DB, Gelman BB, Sacktor NC, Morgello S, Simpson DM, McCutchan JA, Grant I, Letendre SL. Lower CSF Aβ is Associated with HAND in HIV-Infected Adults with a Family History of Dementia. Curr HIV Res. 2016;14(4):324-30. PubMed PMID: 26673902; PubMed Central PMCID: PMC4916008.
  29. Anderson BA, Kronemer SI, Rilee JJ, Sacktor N, Marvel CL. Reward, attention, and HIV-related risk in HIV+ individuals. Neurobiol Dis. 2016 Aug;92(Pt B):157-65. doi: 10.1016/j.nbd.2015.10.018. Epub 2015 Oct 17. PubMed PMID: 26484383; PubMed Central PMCID: PMC4834284.
  30. Hines LJ, Miller EN, Hinkin CH, Alger JR, Barker P, Goodkin K, Martin EM, Maruca V, Ragin A, Sacktor N, Sanders J, Selnes O, Becker JT; Multicenter AIDS Cohort Study. Cortical brain atrophy and intra-individual variability in neuropsychological test performance in HIV disease. Brain Imaging Behav. 2016 Sep;10(3):640-51. doi: 10.1007/s11682-015-9441-1. PubMed PMID: 26303224; PubMed Central PMCID: PMC4767700.
  31. Hulgan T, Samuels DC, Bush W, Ellis RJ, Letendre SL, Heaton RK, Franklin DR, Straub P, Murdock DG, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I, Kallianpur AR; CHARTER Group. Mitochondrial DNA Haplogroups and Neurocognitive Impairment During HIV Infection. Clin Infect Dis. 2015 Jun 30. pii: civ527. [Epub ahead of print] PubMed PMID: 26129753. PMCID: PMC4599391.
  32. Anderson AM, Fennema-Notestine C, Umlauf A, Taylor MJ, Clifford DB, Marra CM, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Morgello S, Grant I, Letendre SL; CHARTER Group. CSF biomarkers of monocyte activation and chemotaxis correlate with magnetic resonance spectroscopy metabolites during chronic HIV disease. J Neurovirol. 2015 Jun 12. [Epub ahead of print] PubMed PMID: 26069183. PMCID: PMC5008689.
  33. Figuera-Losada M, Stathis M, Dorskind JM, Thomas AG, Bandaru VV, Yoo SW, Westwood NJ, Rogers GW, McArthur JC, Haughey NJ, Slusher BS, Rojas C. Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One. 2015 May 26;10(5):e0124481. doi: 10.1371/journal.pone.0124481. eCollection 2015. PubMed PMID: 26010541; PubMed Central PMCID: PMC4444023.
  34. Sacktor, N., Skolasky, R.L., Seaberg, E., Munro, C., Becker, J.T., Martin, E., Ragin, A., Levine, A., Miller, E. Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study. Neurology. 2016 Jan 26;86(4):334-40. doi: 10.1212/WNL.0000000000002277. Epub 2015 Dec 30. PMID: 26718568 PMCID: PMC4776086.
  35. Heaton RK, Franklin DR Jr, Deutsch R, Letendre S, Ellis RJ, Casaletto K, Marquine MJ, Woods SP, Vaida F, Atkinson JH, Marcotte TD, McCutchan JA, Collier AC, Marra CM, Clifford DB, Gelman BB, Sacktor N, Morgello S, Simpson DM, Abramson I, Gamst AC, Fennema-Notestine C, Smith DM, Grant I; CHARTER Group. Neurocognitive change in the era of HIV combination antiretroviral therapy: the longitudinal CHARTER study. Clin Infect Dis. 2015;60(3):473-80. PMC4303775. PMCID: PMC4303775.
  36. Clifford DB, Vaida F, Kao YT, Franklin DR, Letendre SL, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, Grant I, Heaton RK; CHARTER Group. Absence of neurocognitive effect of hepatitis C infection in HIV-coinfected people. Neurology. 2015 Jan 20;84(3):241-50. doi: 10.1212/WNL.0000000000001156.Epub 2014 Dec 10. PubMed PMID: 25503616; PubMed Central PMCID: PMC4335996.
  37. Thakur KT, McArthur JC, Venkatesan A. CNS infections in 2014: Guns, germs, and will. Lancet Neurol. 2015 Jan;14(1):20-2. doi: 10.1016/S1474-4422(14)70293-5. PubMed PMID: 25496889; PubMed Central PMCID: PMC4419332.
  38. Mutant disrupted-in-schizophrenia 1 in astrocytes: Focus on glutamate metabolism. Abazyan S, Yang EJ, Abazyan B, Xia M, Yang C, Rojas C, Slusher B, Sattler R, Pletnikov M. J Neurosci Res. 2014 Dec;92(12):1659-68. doi: 10.1002/jnr.23459. Epub 2014 Aug 8. PubMed PMID: 25131692.
  39. No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death. Becker JT, Martinson JJ, Penugonda S, Kingsley L, Molsberry S, Reynolds S, Aronow A, Goodkin K, Levine A, Martin E, Miller EN, Munro CA, Ragin A, Sacktor N.  J Neurovirol. 2014 Nov 12. [Epub ahead of print] PubMed PMID: 25388225.
  40. Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. Sacktor N, Miyahara S, Evans S, Schifitto G, Cohen B, Haughey N, Drewes JL, Graham D, Zink MC, Anderson C, Nath A, Pardo CA, McCarthy S, Hosey L, Clifford D; on behalf of the ACTG A5235 team. J Neurovirol. 2014 Nov 7. [Epub ahead of print] PubMed PMID: 25377444.
  41. Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease. Mielke MM, Haughey NJ, Bandaru VV, Zetterberg H, Blennow K, Andreasson U, Johnson SC, Gleason CE, Blazel HM, Puglielli L, Sager MA, Asthana S, Carlsson CM.  Neurobiol Aging. 2014 Nov;35(11):2486-94. doi: 10.1016/j.neurobiolaging.2014.05.019. Epub 2014 May 27. PubMed PMID: 24952994; PubMed Central PMCID: PMC4170854.
  42. Evolving clinical phenotypes in HIV-associated neurocognitive disorders. Sacktor N, Robertson K.  Curr Opin HIV AIDS. 2014 Nov;9(6):517-20. doi: 10.1097/COH.0000000000000102. PubMed PMID: 25203640; PubMed Central PMCID: PMC4212639.
  43. Controversies in HIV-associated neurocognitive disorders.Nightingale S, Winston A, Letendre S, Michael BD, McArthur JC, Khoo S, Solomon T.  Lancet Neurol. 2014 Nov;13(11):1139-1151. doi: 10.1016/S1474-4422(14)70137-1. Review. PubMed PMID: 25316020.
  44. Epidermal nerve fiber density, oxidative stress, and mitochondrial haplogroups in HIV-infected Thais initiating therapy. Hulgan T, Levinson RT, Gerschenson M, Phanuphak N, Ananworanich J, Teeratakulpisarm N, Jadwattanakul T, LiButti DE, Fink H, McArthur JC, Ebenezer GJ, Hauer P, Murdock D, Shikuma CM, Samuels DC; SEARCH 003 Study Team.  AIDS. 2014 Jul 17;28(11):1625-33. doi: 10.1097/QAD.0000000000000297. PubMed PMID: 24785954.
  45. Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Grant I, Franklin DR Jr, Deutsch R, Woods SP, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Heaton RK; CHARTER Group. Neurology. 2014 Jun 10;82(23):2055-62. doi: 10.1212/WNL.0000000000000492. Epub 2014 May 9. PubMed PMID: 24814848; PubMed Central PMCID: PMC4118496.
  46. HIV subtype is not associated with dementia among individuals with moderate and advanced immunosuppression in Kampala, Uganda. Sacktor N, Nakasujja N, Redd AD, Manucci J, Laeyendecker O, Wendel SK, Porcella SF, Martens C, Bruno D, Skolasky RL, Okonkwo OC, Robertson K, Musisi S, Katabira E, Quinn TC.  Metab Brain Dis. 2014 Jun;29(2):261-8. doi: 10.1007/s11011-014-9498-3. Epub 2014 Feb 12. PubMed PMID: 24515303; PubMed Central PMCID: PMC4024330.
  47. Cohort Profile: Recruitment cohorts in the neuropsychological substudy of the Multicenter AIDS Cohort Study.Becker JT, Kingsley LA, Molsberry S, Reynolds S, Aronow A, Levine AJ, Martin E, Miller EN, Munro CA, Ragin A, Sacktor N, Selnes OA.  Int J Epidemiol. 2014 Apr 24. [Epub ahead of print] PubMed PMID: 24771276.
  48. Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. Ferraris D, Duvall B, Delahanty G, Mistry B, Alt J, Rojas C, Rowbottom C, Sanders K, Schuck E, Huang KC, Redkar S, Slusher BB, Tsukamoto T. J Med Chem. 2014 Mar 27;57(6):2582-8. doi: 10.1021/jm401856k. Epub 2014 Feb 24. PubMed PMID: 24520856.
  49. Genetic variation in iron metabolism is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy. Kallianpur AR, Jia P, Ellis RJ, Zhao Z, Bloss C, Wen W, Marra CM, Hulgan T, Simpson DM, Morgello S, McArthur JC, Clifford DB, Collier AC, Gelman BB, McCutchan JA, Franklin D, Samuels DC, Rosario D, Holzinger E, Murdock DG, Letendre S, Grant I; CHARTER Study Group.  PLoS One. 2014 Aug 21;9(8):e103123. doi: 10.1371/journal.pone.0103123. eCollection 2014. PubMed PMID: 25144566; PubMed Central PMCID: PMC4140681.
  50. Genetic variation in iron metabolism is associated with neuropathic pain and pain severity in HIV-infected patients on antiretroviral therapy. Kallianpur AR, Jia P, Ellis RJ, Zhao Z, Bloss C, Wen W, Marra CM, Hulgan T, Simpson DM, Morgello S, McArthur JC, Clifford DB, Collier AC, Gelman BB, McCutchan JA, Franklin D, Samuels DC, Rosario D, Holzinger E, Murdock DG, Letendre S, Grant I; CHARTER Study Group. PLoS One. 2014 Aug 21;9(8):e103123. doi: 10.1371/journal.pone.0103123. eCollection 2014. PubMed PMID: 25144566; PubMed Central PMCID: PMC4140681.
  51. Ceramides predict verbal memory performance in coronary artery disease patients undertaking exercise: a prospective cohort pilot study. Saleem M, Ratnam Bandaru VV, Herrmann N, Swardfager W, Mielke MM, Oh PI, Shammi P, Kiss A, Haughey NJ, Rovinski R, Lanctôt KL.  BMC Geriatr. 2013 Dec 12;13:135. doi: 10.1186/1471-2318-13-135. PubMed PMID: 24330446; PubMed Central PMCID: PMC3924163.
  52. Long-term predictive value of the Framingham Risk Score for Stroke in HIV-positive vs HIV-negative men.  Mateen FJ, Post WS, Sacktor N, Abraham AG, Becker JT, Smith BR, Detels R, Martin E, Phair JP, Shinohara RT; Multicenter AIDS Cohort Study (MACS) Investigators.  Neurology. 2013 Dec 10;81(24):2094-102. doi: 10.1212/01.wnl.0000437296.97946.73. Epub 2013 Nov 8. PubMed PMID: 24212385; PubMed Central PMCID: PMC3863354.
  53. A biological perspective of CSF lipids as surrogate markers for cognitive status in HIV. Haughey NJ, Zhu X, Bandaru VV.  J Neuroimmune Pharmacol. 2013 Dec;8(5):1136-46. doi: 10.1007/s11481-013-9506-0. Epub 2013 Nov 8. Review. PubMed PMID: 24203462; PubMed Central PMCID: PMC3909934.
  54. Older individuals with HIV infection have greater memory deficits than younger individuals. Tan IL, Smith BR, Hammond E, Vornbrock-Roosa H, Creighton J, Selnes O, McArthur JC, Sacktor N. J Neurovirol. 2013 Dec;19(6):531-6. PubMed PMID: 24078559; PubMed Central PMCID: PMC3946697.
  55. A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects. Bandaru VV, Mielke MM, Sacktor N, McArthur JC, Grant I, Letendre S, Chang L, Wojna V, Pardo C, Calabresi P, Munsaka S, Haughey NJ.  Neurology. 2013 Oct 22;81(17):1492-9. doi: 10.1212/WNL.0b013e3182a9565e. Epub 2013 Sep 11. PubMed PMID: 24027056; PubMed Central PMCID: PMC3888167.
  56. Sleep, function and HIV: a multi-method assessment. Gamaldo CE, Spira AP, Hock RS, Salas RE, McArthur JC, David PM, Mbeo G, Smith MT. AIDS Behav. 2013 Oct;17(8):2808-15. doi: 10.1007/s10461-012-0401-0. PubMed PMID: 23299876.
  57. A novel computerized functional assessment for human immunodeficiency virus-associated neurocognitive disorder. Rosenthal LS, Skolasky RL, Moxley RT 4th, Roosa HV, Selnes OA, Eschman A, McArthur JC, Sacktor N.  J Neurovirol. 2013 Oct;19(5):432-41. doi: 10.1007/s13365-013-0195-5. Epub 2013 Oct 1. PubMed PMID: 24081883; PubMed Central PMCID: PMC3790918.
  58. Evaluating sleep and cognition in HIV. Gamaldo CE, Gamaldo A, Creighton J, Salas RE, Selnes OA, David PM, Mbeo G, Parker BS, Brown A, McArthur JC, Smith MT. J Acquir Immune Defic Syndr. 2013 Aug 15;63(5):609-16. doi: 10.1097/QAI.0b013e31829d63ab. PubMed PMID: 23722610; PubMed Central PMCID: PMC3822901.
  59. Experience and challenges presented by a multicenter crossover study of combination analgesic therapy for the treatment of painful HIV-associated polyneuropathies. Harrison T, Miyahara S, Lee A, Evans S, Bastow B, Simpson D, Gilron I, Dworkin R, Daar ES, Wieclaw L, Clifford DB; ACTG A5252 Team. Pain Med. 2013 Jul;14(7):1039-47. doi: 10.1111/pme.12084. Epub 2013 Apr 8. PubMed PMID: 23565581; PubMed Central PMCID: PMC4207215.
  60. Relationships among neurocognitive status, medication adherence measured by pharmacy refill records, and virologic suppression in HIV-infected persons. Andrade AS, Deutsch R, A Celano S, Duarte NA, Marcotte TD, Umlauf A, Atkinson JH, McCutchan JA, Franklin D, Alexander TJ, McArthur JC, Marra C, Grant I, Collier AC. J Acquir Immune Defic Syndr. 2013 Mar 1;62(3):282-92. doi: 10.1097/QAI.0b013e31827ed678. PubMed PMID: 23202813; PubMed Central PMCID: PMC3906725.
  61. Neuropsychological test performance before and after HIV-1 seroconversion: the Multicenter AIDS Cohort Study.Vo QT, Cox C, Li X, Jacobson LP, McKaig R, Sacktor N, Selnes OA, Martin E, Becker JT, Miller EN.  J Neurovirol. 2013 Feb;19(1):24-31. doi: 10.1007/s13365-012-0136-8. Epub 2012 Dec 11. PubMed PMID: 23229349; PubMed Central PMCID: PMC3568242.
  62. Longitudinal neuropsychological test performance among HIV seropositive individuals in Uganda. Sacktor N, Nakasujja N, Okonkwo O, Skolasky RL, Robertson K, Musisi S, Katabira E.  J Neurovirol. 2013 Feb;19(1):48-56. doi: 10.1007/s13365-012-0139-5. Epub 2013 Jan 12. PubMed PMID: 23315423; PubMed Central PMCID: PMC3568232.
  63. Global NeuroAIDS roundtable. Joseph J, Achim CL, Boivin MJ, Brew BJ, Clifford DB, Colosi DA, Ellis RJ, Heaton RK, Gallo-Diop A, Grant I, Kanmogne GD, Kumar M, Letendre S, Marcotte TD, Nath A, Pardo CA, Paul RH, Pulliam L, Robertson K, Royal W 3rd, Sacktor N, Sithinamsuwan P, Smith DM, Valcour V, Wigdahl B, Wood C.  J Neurovirol. 2013 Feb;19(1):1-9. doi: 10.1007/s13365-012-0143-9. Epub 2013 Jan 26. PubMed PMID: 23354550; PubMed Central PMCID: PMC3713197.
  64. Neurologic Complications and Considerations in HIV-Infected Persons. McArthur J, Smith B.  Curr Infect Dis Rep. 2013 Feb;15(1):61-6. doi: 10.1007/s11908-012-0312-2. PubMed PMID: 23307491.
  65. Randomized trial of minocycline in the treatment of HIV-associated cognitive impairment. Nakasujja N, Miyahara S, Evans S, Lee A, Musisi S, Katabira E, Robertson K, Ronald A, Clifford DB, Sacktor N. Neurology. 2013 Jan 8;80(2):196-202. doi: 10.1212/WNL.0b013e31827b9121. Epub 2012 Dec 26. PubMed PMID: 23269596; PubMed Central PMCID: PMC3589188.
  66. Concurrent classification accuracy of the HIV dementia scale for HIV-associated neurocognitive disorders in the CHARTER Cohort. Sakamoto M, Marcotte TD, Umlauf A, Franklin D Jr, Heaton RK, Ellis RJ, Letendre S, Alexander T, McCutchan JA, Morgan EE, Woods SP, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson D, Grant I; CHARTER Group. J Acquir Immune Defic Syndr. 2013 Jan 1;62(1):36-42. doi: 10.1097/QAI.0b013e318278ffa4. PubMed PMID: 23111573; PubMed Central PMCID: PMC3529802.
  67. RFactors affecting brain structure in men with HIV disease in the post-HAART era.
    Becker JT, Maruca V, Kingsley LA, Sanders JM, Alger JR, Barker PB, Goodkin K, Martin E, Miller EN, Ragin A, Sacktor N, Selnes O; Multicenter AIDS Cohort Study.
    Neuroradiology. 2012 Feb;54(2):113-21. Epub 2011 Mar 22. PMID:21424708
  68. Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CCR5-tropic HIV-1 50% inhibitory concentration.
    Croteau D, Best BM, Letendre S, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Grant I; for the CHARTER Group.
    AIDS. 2012 Feb 4. PMID:22313954
  69. LOW CSF CONCENTRATIONS OF THE NUCLEOTIDE HIV REVERSE TRANSCRIPTASE INHIBITOR, TENOFOVIR.
    Best BM, Letendre SL, Koopmans P, Rossi SS, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Capparelli EV, Ellis RJ, Grant I; the CHARTER Study Group.
    J Acquir Immune Defic Syndr. 2012 Jan 3. PMID:22217676
  70. Progressive multifocal leukoencephalopathy in a patient without immunodeficiency.
    Sethi NK, Torgovnick J, McArthur JC, Tan IL, Koralnik IJ.
    Neurology. 2012 Jan 3;78(1):73; author response 73-4. PMID:22201115
  71. Diagnosing symptomatic HIV-associated neurocognitive disorders: self-report versus performance-based assessment of everyday functioning.
    Blackstone K, Moore DJ, Heaton RK, Franklin DR Jr, Woods SP, Clifford DB, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, Rivera-Mindt M, Deutsch R, Ellis RJ, Hampton Atkinson J, Grant I; CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Group.
    J Int Neuropsychol Soc. 2012 Jan;18(1):79-88. Epub 2011 Nov 24. PMID:22114912
  72. Peripheral Neuropathy in HIV: prevalence and risk factors
    Evans SR, Ellis RJ, Chen H, Yeh TM, Lee AJ, Schifitto G, Wu K, Bosch RJ, McArthur JC, Simpson DM, Clifford DB.
    AIDS. 2011 Mar 10. [Epub ahead of print] PMID: 21302026
  73. HIV-associated neurocognitive disorders: is there a hidden epidemic? 
    McArthur JC, Brew BJ.
    AIDS. 2010 Jun 1;24(9):1367-70.
  74. Human immunodeficiency virus-associated neurocognitive disorders: Mind the gap
    McArthur JC, Steiner J, Sacktor N, Nath A.
    Ann Neurol. 2010 Jun;67(6):699-714.
  75. Longitudinal psychomotor speed performance in HIV+ individuals: impact of age and serostatus
    Sacktor, N., Skolasky, R.L., Cox, C., Selnes, O., Becker, J.T., Cohen, B., Martin, E., Miller, E., for the Multicenter AIDS Cohort Study (MACS).
    J NeuroVirology 2010; 335-341.
  76. Comparison of scales to evaluate the progression of HIV-associated neurocognitive disorder
    Gandhi,N; Moxley R; Creighton,J.; Vornbrock Roosa,H; Selnes,O.; McArthur J.C.; Sacktor N.  
    HIV Therapy 2010 4: 3:371-379.
  77. Translational research in neuroAIDS: A neuroimmune pharmacology-related course
    Brown, A., Shiramizu, B., Nath, A., and V. Wojna. 
    2010 (Epub May 25).
  78. Neurologic disease burden in treated HIV/AIDS predicts survival: a population-based study
    Vivithanaporn P, Heo G, Gamble J, Krentz HB, Höke A, Gill MJ, Power C.
    Neurology 2010 Vol: 75(13); pp: 1150-8.
  79. Mirtazapine use in Human Immunodeficiency Virus-infected patients with Progressive Multifocal Leukoencephalopathy.
    Cettomai Deanna, McArthur Justin C.
    Archives of Neurology. 66(2): 255-258, Feb 2009. PMID:  19204164
  80. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
    Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C. 
    FASEB J. 2009 Sep;23(9):2928-41. Epub 2009 Apr 20.  PMID: 19380511
  81. Benefits and risks of stavudine therapy for HIV associated neurological complications in Uganda.
    Sacktor, N, Nakasujja, N., Skolasky, R., Robertson, K., Musisi, S., Ronald, A., Katabira, E., Clifford, D. B.
    Neurology. 2009; 72:165-170. PMID: 19139369
  82. HIV subtype D is associated with dementia, compared with subtype A, in immunosuppressed individuals at risk of cognitive impairment in Kampala, Uganda. 
    Sacktor N, Nakasujja N, Skolasky RL, Rezapour M, Robertson K, Musisi S, Katabira E, Ronald A, Clifford DB, Laeyendecker O, Quinn TC.
    Clin Infect Dis.  2009 Sep 1; 49(5):780-6. PMID:  19622045
  83. Evidence for Neurocognitive Plasticity in At-risk Older Adults: The Experience Corps Program. 
    Carlson, M.C., Erickson, K.I., Kramer, A.F., Voss, M.W., Bolea, N., Mielke, M., McGill, S., Rebok, G.W., Seeman, T., Fried, L.P.
    Journal of Gerontology Medical Sciences 2009 64(12):1275-1282.
  84. New insights into HIV neuropathogenesis.
    Johnson T, Nath A
    In Robert Paul, Ned Sacktor, Victor Valcour, Karen Tokie Tashima (Eds), HIV and the Brain: New Challenges in the Modern Era (Current Clinical Neurology)
    Humana Press Inc. Totowa NJ; March 9, 2009.
  85. Evolution of HIV dementia with HIV infection.
    Nath A, Schiess N, Venkatesan A, Rumbaugh J, Sacktor N, McArthur J.
    Int Rev Psychiatry. 20: 25-31; 2008. PMID: 18240060
  86. Developing Neuroprotective Strategies for Treatment of HIV-associated Neurocognitive Dysfunction.
    Rumbaugh JA, Steiner J, Sacktor N, Nath A.
    Future HIV Therapy. 2(3), 271-280; 2008. PMID: 19774095
  87. Updated research nosology for HIV-associated neurocognitive disorders
    Antinori A, Arendt G, Becker JT, Brew BJ, Byrd DA, Cherner M, Clifford DB, Cinque P, Epstein LG, Goodkin K, Gisslen M, Grant I, Heaton RK, Joseph J, Marder K, Marra CM, McArthur JC, Nunn M, Price RW, Pulliam L, Robertson KR, Sacktor N, Valcour V, Wojna VE.
    Neurology. 69 (18): 1789-1799, Oct. 30, 2007. Epub Oct 3, 2007.  PMID:  17914061
  88. Associative and predictive biomarkers of dementia in HIV-1-infected patients. Neurology
    Bandaru VV, McArthur JC, Sacktor N, Cutler RG, Knapp EL, Mattson MP, Haughey NJ
    Neurology. 68 (18): 1481-1487, May 2007.  PMID: 17470750
  89. The HIV Dementia Scale: predictive power in mild dementia and HAART
    Bottiggi KA, Chang JJ, Schmitt FA, Avison MJ, Mootoor Y, Nath A, Berger JR
    J Neurol Sci. 2007 Sep 15;260(1-2):11-5. Epub 2007 May 4.  PMID: 17482212
  90. Neurological function and HIV risk behaviors of female prison inmates
    Brewer-Smyth K, Bucurescu G, Shults J, Metzger D, Sacktor N, van Gorp W, Kolson D. 
    J Neurosci Nurs. 2007 Dec;39(6):361-72. PMID: 18186421
  91. A randomized trial evaluating Prosaptide for HIV-associated sensory neuropathies; use of an electronic diary to record neuropathic pain
    Evans, SR, Simpson DM, Kitch DW, King A, Clifford DB, Cohen BA, McArthur JC; Neurologic AIDS Research Consortium; AIDS Clinical Trials Group.
    PLos ONE. 2(6): e551. July 25 2007. PMID: 17653259
  92. New techniques for imaging Human Immunodeficiency Virus associated cognitive impairment in the era of highly active antiretroviral therapy
    Pomper MG, Sacktor N.
    Archives of Neurology. 64 (9): 1233-1235, Sep 2007.  PMID:  17846261
  93. The prevalence and incidence of neurocognitive impairment in the HAART era
    Robertson KR, Smurzynski M, Parsons TD, Wu K, Bosch RJ, Wu J, McArthur JC, Collier AC, Evans SR, Ellis RJ.
    AIDS. 21(14): 1915-1921, Sep 12 2007. PMID: 17721099
  94. Pattern of neuropsychological performance among HIV positive patients in Uganda
    Robertson KR, Nakasujja N, Wong M, Musisi S, Katabira E, Parsons TD, Ronald A, Sacktor N. 
    BMC Neurol. 2007 Apr 5;7:8. PMID: 17411437
  95. HIV-associated cognitive impairment in sub-Saharan Africa--the potential effect of clade diversity
    Sacktor N, Nakasujja N, Robertson K, Clifford DB.  
    Nat Clin Pract Neurol. 2007 Aug;3(8):436-43.  PMID: 17671521
  96. Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study
    Schifitto G, Navia BA, Yiannoutsos CT, Marra CM, Chang L, Ernst T, Jarvik JG, Miller EN, Singer EJ, Ellis RJ, Kolson DL, Simpson D, Nath A, Berger J, Shriver SL, Millar LL, Colquhoun D, Lenkinski R, Gonzalez RG, Lipton SA; Adult AIDS Clinical Trial Group (ACTG) 301; 700 Teams; HIV MRS Consortium.  
    AIDS. 2007 Sep 12;21(14):1877-86. PMID: 17721095
  97. An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infection
    Sevigny JJ, Albert SM, McDermott MP, Schifitto G, McArthur JC, Sacktor N, Conant K, Selnes OA, Stern Y, McClernon DR, Palumbo D, Kieburtz K, Riggs G, Cohen B, Marder K, Epstein LG.
    Archives of Neurology. 64(1):97-102, Jan 2007.  PMID: 17210815
  98. Spanish validation of the HIV dementia scale in women
    Wojna V, Skolasky RL, McArthur JC, Maldonado E, Hechavarria R, Mayo R, Selnes O, Ginebra T, de la Torre T, Garcia H, Kraiselburd E, Melendez-Guerrero LM, Zorrilla CD, Nath A.
    AIDS Patient Care STDS. 21 (12): 930-941, Dec 2007.  PMID:  18154490
  99. Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus-seropositive women
    Wojna V, Robles L, Skolasky RL, Mayo R, Selnes O, de la Torre T, Maldonado E, Nath A, Meléndez LM, Lasalde-Dominicci J.  
    J Neurovirol. 2007 Dec;13(6):561-8.  PMID: 18097887
  100. Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa
    Wong, MH, Robertson K, Nakasujja N, Skolasky R, Musisi S, Katabira E, McArthur JC, Ronald A, Sacktor N.
    Neurology. 68(5):350-355, Jan 30 2007.  PMID: 17261681
  101. Translational research models and novel adjunctive therapies for neuroAIDS
    Zink MC.  
    J Neuroimmune Pharmacol. 2007 Mar;2(1):14-9. Epub 2007 Jan 9.  PMID: 18040821