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Neurology and Neurosurgery

Johns Hopkins Center for the Advancement of HIV Neurotherapeutics

Basic Research Publications

  1. Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network.
    Skácel, J., Slusher, B. S., & Tsukamoto, T. (2021). Journal of medicinal chemistry, 64(1), 279–297. https://doi.org/10.1021/acs.jmedchem.0c01664.

  2. Disruption of the cholinergic anti-inflammatory response by R5-tropic HIV-1 protein gp120JRFL.
    Ríos, S. C., Colón Sáez, J. O., Quesada, O., Figueroa, K. Q., & Lasalde Dominicci, J. A. (2021). The Journal of biological chemistry, 296, 100618. https://doi.org/10.1016/j.jbc.2021.100618

  3. Large Mitochondrial DNA Deletions in HIV Sensory Neuropathy.
    Roda, Ricardo H; Bargiela, David; Chen, Weiran; Perry, Ken; Ellis, Ronald J; Clifford, David B; Bharti, Ajay; Kallianpur, Asha R; Oliveira, Michelli F; Diaz, Monica M; Rubin, Leah H; Gavegnano, Christina; McArthur, Justin C; Hoke, Ahmet; Polydefkis, Michael. Neurology 2021 07 13; 97 (2) e156-e165.

  4. Evaluation of a screening tool for the identification of neurological disorders in rural Uganda.
    Tran, Andy; Thakur, Kiran T; Nakasujja, Noeline; Nakigozi, Gertrude; Kisakye, Alice; Batte, James; Mayanja, Richard; Anok, Aggrey; Gray, Ronald H; Wawer, Maria J; Rubin, Leah H; Sacktor, Ned; Saylor, Deanna. Journal of the neurological sciences 2021 Feb 15; 421 117273

  5. Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases.
    Tallon, Carolyn; Hollinger, Kristen R; Pal, Arindom; Bell, Benjamin J; Rais, Rana; Tsukamoto, Takashi; Witwer, Kenneth W; Haughey, Norman J; Slusher, Barbara S. Drug discovery today 2021 07; 26 (7) 1656-1668

  6. Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?
    Deme, Pragney; Rojas, Camilo; Slusher, Barbara S; Rais, Raina; Afghah, Zahra; Geiger, Jonathan D; Haughey, Norman J. Experimental neurology 2020 05; 327 113181.

  7. Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP.
    Li, Zhigang; Moniruzzaman, Mohammed; Dastgheyb, Raha M; Yoo, Seung-Wan; Wang, Meina; Hao, Hongbo; Liu, Jia; Casaccia, Patrizia; Nogueras-Ortiz, Carlos; Kapogiannis, Dimitrios; Slusher, Barbara S; Haughey, Norman J. Journal of extracellular vesicles 2020 12; 10 (2) e12035

  8. Looking for Drugs in All the Wrong Places: Use of GCPII Inhibitors Outside the Brain.
    Vornov, James J; Peters, Diane; Nedelcovych, Mike; Hollinger, Kristen; Rais, Rana; Slusher, Barbara S. Neurochemical research 2020 Jun; 45 (6) 1256-1267

  9. Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice.
    Hollinger, Kristen R; Zhu, Xiaolei; Khoury, Elizabeth S; Thomas, Ajit G; Liaw, Kevin; Tallon, Carolyn; Wu, Ying; Prchalova, Eva; Kamiya, Atsushi; Rojas, Camilo; Kannan, Sujatha; Slusher, Barbara S. Journal of Alzheimer's disease : JAD 2020; 77 (1) 437-447

  10. Cognitive Trajectory Phenotypes in Human Immunodeficiency Virus-Infected Patients. Dastgheyb RM, Sacktor N, Franklin D, Letendre S, Marcotte T, Heaton R, Grant I, McArthur JC, Rubin LH, Haughey NJ. J Acquir Immune Defic Syndr. 2019 Sep 1;82(1):61-70. doi: 10.1097/QAI.0000000000002093. PMID: 31107302

  11. Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice. Kim BH, Kelschenbach J, Borjabad A, Hadas E, He H, Potash MJ, Nedelcovych MT, Rais R, Haughey NJ, McArthur JC, Slusher BS, Volsky DJ. AIDS. 2019 May 1;33(6):973-984. doi: 10.1097/QAD.0000000000002150. PMID: 30946151
  12. Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice. Kim BH, Kelschenbach J, Borjabad A, Hadas E, He H, Potash MJ, Nedelcovych MT, Rais R, Haughey NJ, McArthur JC, Slusher BS, Volsky DJ. AIDS. 2019 May 1;33(6):973-984. doi: 10.1097/QAD.0000000000002150. PMID: 30946151
  13. Impaired insulin sensitivity is associated with worsening cognition in HIV-infected patients. Khuder SS, Chen S, Letendre S, Marcotte T, Grant I, Franklin D, Rubin LH, Margolick JB, Jacobson LP, Sacktor N, D'Souza G, Stosor V, Lake JE, Rapocciolo G, McArthur JC, Dickens AM, Haughey NJ. Neurology. 2019 Mar 19;92(12):e1344-e1353. doi: 10.1212/WNL.0000000000007125. Epub 2019 Feb 20. PMID: 30787163
  14. The Psychiatric Impact of HIV. Nedelcovych MT, Manning AA, Semenova S, Gamaldo C, Haughey NJ, Slusher BS. ACS Chem Neurosci. 2017 Jul 19;8(7):1432-1434. doi: 10.1021/acschemneuro.7b00169. Epub 2017 May 24. PMID: 28537385.
  15. Piepenbrink MS, Samuel M, Zheng B, Carter B, Fucile C, Bunce C, Kiebala M, Khan AA, Thakar J, Maggirwar SB, Morse D, Rosenberg AF, Haughey NJ, Valenti W, Keefer MC, Kobie JJ. Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users. PLoS One. 2016 Jul 5;11(7):e0158641. doi: 10.1371/journal.pone.0158641. eCollection 2016. PubMed PMID: 27379802; PubMed Central PMCID: PMC4933366.
  16. Gonzalez CE, Venkatraman VK, An Y, Landman BA, Davatzikos C, Ratnam Bandaru VV, Haughey NJ, Ferrucci L, Mielke MM, Resnick SM. Peripheral sphingolipids are associated with variation in white matter microstructure in older adults. Neurobiol Aging. 2016 Jul;43:156-63. doi: 10.1016/j.neurobiolaging.2016.04.008. Epub 2016 Apr 21. PubMed PMID: 27255825; PubMed Central PMCID: PMC4894643.
  17. Fabbri E, Yang A, Simonsick EM, Chia CW, Zoli M, Haughey NJ, Mielke MM, Ferrucci L, Coen PM. Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54- 96 years from the Baltimore Longitudinal Study of Aging. Aging Cell. 2016 Oct;15(5):825-31. doi: 10.1111/acel.12491. Epub 2016 May 2. PubMed PMID: 27135629.
  18. Steiner JP, Bachani M, Wolfson-Stofko B, Lee MH, Wang T, Li G, Li W, Strayer D, Haughey NJ, Nath A. Erratum to: Interaction of Paroxetine with Mitochondrial Proteins Mediates Neuroprotection. Neurotherapeutics. 2016 Jan;13(1):237. doi: 10.1007/s13311-015-0406-2. PubMed PMID: 26692391; PubMed Central PMCID: PMC4720660.
  19. Kumar V, Bonifazi A, Ellenberger MP, Keck TM, Pommier E, Rais R, Slusher BS, Gardner E, You ZB, Xi ZX, Newman AH. Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. J Med Chem. 2016 Aug 25;59(16):7634-50. doi: 10.1021/acs.jmedchem.6b00860. Epub 2016 Aug 10. PubMed PMID: 27508895; PubMed Central PMCID: PMC5001167.
  20. Manivannan S, Baxter VK, Schultz KL, Slusher BS, Griffin DE. Protective effects of glutamine antagonist DON in mice with alphaviral encephalomyelitis. J Virol. 2016 Aug 3. pii: JVI.01045-16. [Epub ahead of print] PubMed PMID: 27489275.
  21. Smith JA, Slusher BS, Wozniak KM, Farah MH, Smiyun G, Wilson L, Feinstein S, Jordan MA. Structural Basis for Induction of Peripheral Neuropathy by Microtubule-Targeting Cancer Drugs. Cancer Res. 2016 Sep 1;76(17):5115-23. doi: 10.1158/0008-5472.CAN-15-3116. Epub 2016 Aug 3. PubMed PMID: 27488522.
  22. Tasnim A, Rammelkamp Z, Slusher AB, Wozniak K, Slusher BS, Farah MH. Paclitaxel causes degeneration of both central and peripheral axon branches of dorsal root ganglia in mice. BMC Neurosci. 2016 Jul 11;17(1):47. doi: 10.1186/s12868-016-0285-4. PubMed PMID: 27401104; PubMed Central PMCID: PMC4940970.
  23. Zhang Z, Bassam B, Thomas AG, Williams M, Liu J, Nance E, Rojas C, Slusher BS, Kannan S. Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain. Neurobiol Dis. 2016 Oct;94:116-28. doi: 10.1016/j.nbd.2016.06.010. Epub 2016 Jun 17. PubMed PMID: 27326668.
  24. Vornov JJ, Hollinger KR, Jackson PF, Wozniak KM, Farah MH, Majer P, Rais R, Slusher BS. Still NAAG'ing After All These Years: The Continuing Pursuit of GCPII Inhibitors. Adv Pharmacol. 2016;76:215-55. doi: 10.1016/bs.apha.2016.01.007. Epub 2016 Mar 18. PubMed PMID: 27288079. PMCID: PMC5394739.
  25. Rojas C, Alt J, Ator NA, Wilmoth H, Rais R, Hin N, DeVivo M, Popiolek M, Tsukamoto T, Slusher BS. Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect. J Psychopharmacol. 2016 Sep;30(9):887- 95. doi: 10.1177/0269881116652586. Epub 2016 Jun 10. PubMed PMID: 27287825.
  26. Zimmermann SC, Wolf EF, Luu A, Thomas AG, Stathis M, Poore B, Nguyen C, Le A, Rojas C, Slusher BS, Tsukamoto T. Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold. ACS Med Chem Lett. 2016 Mar 13;7(5):520-4. doi: 10.1021/acsmedchemlett.6b00060. eCollection 2016 May 12. PubMed PMID: 27200176; PubMed Central PMCID: PMC4868099.
  27. Majer P, Jančařík A, Krečmerová M, Tichý T, Tenora L, Wozniak K, Wu Y, Pommier E, Ferraris D, Rais R, Slusher BS. Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA). J Med Chem. 2016 Mar 24;59(6):2810-9. doi: 10.1021/acs.jmedchem.6b00062. Epub 2016 Mar 10. PubMed PMID: 26930119.
  28. Hollinger KR, Alt J, Riehm AM, Slusher BS, Kaplin AI. Dose-dependent inhibition of GCPII to prevent and treat cognitive impairment in the EAE model of multiple sclerosis. Brain Res. 2016 Mar 15;1635:105-12. doi: 10.1016/j.brainres.2016.01.035. Epub 2016 Jan 26. PubMed PMID: 26826008.
  29. Rojas C, Alt J, Ator NA, Thomas AG, Wu Y, Hin N, Wozniak K, Ferraris D, Rais R, Tsukamoto T, Slusher BS. D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog. Neuropsychopharmacology. 2016 May;41(6):1610-9. doi: 10.1038/npp.2015.319. Epub 2015 Oct 16. PubMed PMID: 26471255; PubMed Central PMCID: PMC4832022.
  30. Shikuma CM, Bennett K, Ananworanich J, Gerschenson M, Teeratakulpisarn N, Jadwattanakul T, DeGruttola V, McArthur JC, Ebenezer G, Chomchey N, Praihirunkit P, Hongchookiat P, Mathajittiphun P, Nakamoto B, Hauer P, Phanuphak P, Phanuphak N; SEARCH 003 protocol team. Distal leg epidermal nerve fiber density as a surrogate marker of HIV-associated sensory neuropathy risk: risk factors and change following initial antiretroviral therapy. J Neurovirol. 2015 May 22. [Epub ahead of print] PubMed PMID: 26002840. PMCID: PMC4611029.
  31. Dickens AM, Anthony DC, Deutsch R, Mielke MM, Claridge TD, Grant I, Franklin D, Rosario D, Marcotte T, Letendre S, McArthur JC, Haughey NJ. Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients. AIDS. 2015 Mar 13;29(5):559-69. doi: 10.1097/QAD.0000000000000580. PubMed PMID: 25611149; PubMed Central PMCID: PMC4340743.
  32. Mangus LM, Dorsey JL, Laast VA, Hauer P, Queen SE, Adams RJ, McArthur JC, Mankowski JL. Neuroinflammation and virus replication in the spinal cord of simian immunodeficiency virus-infected macaques. J Neuropathol Exp Neurol. 2015 Jan;74(1):38-47. doi: 10.1097/NEN.0000000000000148. PubMed PMID: 25470348; PubMed Central PMCID: PMC4270881.
  33. Molsberry SA, Lecci F, Kingsley L, Junker B, Reynolds S, Goodkin K, Levine AJ, Martin E, Miller EN, Munro CA, Ragin A, Sacktor N, Becker JT. Mixed membership trajectory models of cognitive impairment in the multicenter AIDS cohort study. AIDS. 2015 Mar 27;29(6):713-21. doi: 10.1097/QAD.0000000000000561. PubMed PMID: 25565498. PMCID: PMC4743499.
  34. Becker JT, Martinson JJ, Penugonda S, Kingsley L, Molsberry S, Reynolds S, Aronow A, Goodkin K, Levine A, Martin E, Miller EN, Munro CA, Ragin A, Sacktor N. No association between Apoε4 alleles, HIV infection, age, neuropsychological outcome, or death. J Neurovirol. 2015 Feb;21(1):24-31. doi: 10.1007/s13365-014- 0290-2. Epub 2014 Nov 12. PubMed PMID: 25388225; PubMed Central PMCID: PMC4319994.
  35. Lake JE, Vo QT, Jacobson LP, Sacktor N, Miller EN, Post WS, Becker JT, Palella FJ Jr, Ragin A, Martin E, Munro CA, Brown TT. Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men. Antivir Ther. 2015;20(2):235-44. doi: 10.3851/IMP2952. Epub 2015 Mar 26. PubMed PMID: 25810377; PubMed Central PMCID: PMC4425574.
  36. Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ. Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. Aging Cell. 2015 Jul 20. doi: 10.1111/acel.12369. [Epub ahead of print] PubMed PMID: 26193443. PMCID: PMC4693456.
  37. Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ. Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging. Aging Cell. 2015 Feb;14(1):112-21. doi: 10.1111/acel.12275. Epub 2014 Oct 24. PubMed PMID: 25345489; PubMed Central PMCID: PMC4310757.
  38. Steiner JP, Bachani M, Wolfson-Stofko B, Lee MH, Wang T, Li G, Li W, Strayer D, Haughey NJ, Nath A. Interaction of paroxetine with mitochondrial proteins mediates neuroprotection. Neurotherapeutics. 2015 Jan;12(1):200-16. doi: 10.1007/s13311-014-0315-9. PubMed PMID: 25404050; PubMed Central PMCID: PMC4322069.
  39. Brown A. Understanding the MIND phenotype: macrophage/microglia inflammation in neurocognitive disorders related to human immunodeficiency virus infection. Clin Transl Med. 2015 Feb 26;4:7. doi: 10.1186/s40169-015-0049-2. eCollection 2015. PubMed PMID: 25852823; PubMed Central PMCID: PMC4385031.
  40. Cashman CR, Höke A. Mechanisms of distal axonal degeneration in peripheral neuropathies. Neurosci Lett. 2015 Jun 2;596:33-50. doi: 10.1016/j.neulet.2015.01.048. Epub 2015 Jan 21. Review. PubMed PMID: 25617478; PubMed Central PMCID: PMC4428955.
  41. Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging.Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ.  Aging Cell. 2014 Oct 24. doi: 10.1111/acel.12275. [Epub ahead of print] PubMed PMID: 25345489.
  42. Spinal Cord Injury Causes Chronic Liver Pathology in Rats. Sauerbeck AD, Laws JL, Bandaru VV, Popovich PG, Haughey NJ, McTigue DM.  J Neurotrauma. 2014 Oct 21. [Epub ahead of print] PubMed PMID: 25036371.
  43. Identification of putative biomarkers for HIV-associated neurocognitive impairment in the CSF of HIV-infected patients under cART therapy determined by mass spectrometry. Bora A, Mohien CU, Chaerkady R, Chang L, 4th Moxley R, Sacktor N, Haughey N, McArthur JC, Cotter R, Nath A, Graham DR. J Neurovirol. 2014 Oct;20(5):457-465. Epub 2014 Jul 24. PubMed PMID: 25056907.
  44. Peptidomimetics of Arg-Phe-NH 2 as small molecule agonists of Mas-related gene C (MrgC) receptors. Hin N, Alt J, Zimmermann SC, Delahanty G, Ferraris DV, Rojas C, Li F, Liu Q, Dong X, Slusher BS, Tsukamoto T.  Bioorg Med Chem. 2014 Sep 19. pii: S0968-0896(14)00671-3. doi: 10.1016/j.bmc.2014.09.025. [Epub ahead of print] PubMed PMID: 25288495.
  45. Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection. Bae M, Patel N, Xu H, Lee M, Tominaga-Yamanaka K, Nath A, Geiger J, Gorospe M, Mattson MP, Haughey NJ.  J Neurosci. 2014 Aug 20;34(34):11485-503. doi: 10.1523/JNEUROSCI.0210-14.2014. PubMed PMID: 25143627; PubMed Central PMCID: PMC4138351.
  46. Activation of MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory neurons in mice. Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu Q, Tang Z, Han L, Chu YX, Wang Y, Hin N, Tsukamoto T, Slusher B, Guan X, Wei F, Raja SN, Dong X, Guan Y.  Pain. 2014 Aug;155(8):1613-21. doi: 10.1016/j.pain.2014.05.008. Epub 2014 May 9. PubMed PMID: 24813294; PubMed Central PMCID: PMC4104261.
  47. Netupitant and palonosetron trigger NK1 receptor internalization in NG108-15 cells. Thomas AG, Stathis M, Rojas C, Slusher BS.  Exp Brain Res. 2014 Aug;232(8):2637-44. doi: 10.1007/s00221-014-4017-7. Epub 2014 Jun 27. PubMed PMID: 24969614; PubMed Central PMCID: PMC4112047.
  48. Cerebrospinal fluid ceramides from patients with multiple sclerosis impair neuronal bioenergetics. Vidaurre OG, Haines JD, Katz Sand I, Adula KP, Huynh JL, McGraw CA, Zhang F, Varghese M, Sotirchos E, Bhargava P, Bandaru VV, Pasinetti G, Zhang W, Inglese M, Calabresi PA, Wu G, Miller AE, Haughey NJ, Lublin FD, Casaccia P. Brain. 2014 Aug;137(Pt 8):2271-86. doi: 10.1093/brain/awu139. Epub 2014 Jun 3. PubMed PMID: 24893707; PubMed Central PMCID: PMC4164163.
  49. The cerebrospinal fluid HIV risk score for assessing central nervous system activity in persons with HIV.Hammond ER, Crum RM, Treisman GJ, Mehta SH, Marra CM, Clifford DB, Morgello S, Simpson DM, Gelman BB, Ellis RJ, Grant I, Letendre SL, McArthur JC; CHARTER Group.  Am J Epidemiol. 2014 Aug 1;180(3):297-307. doi: 10.1093/aje/kwu098. Epub 2014 Jun 24. PubMed PMID: 24966216; PubMed Central PMCID: PMC4108039.
  50. Ceramide metabolism analysis in a model of binge drinking reveals both neuroprotective and toxic effects of ethanol. Bae M, Bandaru VV, Patel N, Haughey NJ. J Neurochem. 2014 Jul 24. doi: 10.1111/jnc.12834. [Epub ahead of print] PubMed PMID: 25060779.
  51. Regional brain distribution of translocator protein using [(11)C]DPA-713 PET in individuals infected with HIV.Coughlin JM, Wang Y, Ma S, Yue C, Kim PK, Adams AV, Roosa HV, Gage KL, Stathis M, Rais R, Rojas C, McGlothan JL, Watkins CC, Sacktor N, Guilarte TR, Zhou Y, Sawa A, Slusher BS, Caffo B, Kassiou M, Endres CJ, Pomper MG J Neurovirol. 2014 Jun;20(3):219-32. doi: 10.1007/s13365-014-0239-5. Epub 2014 Feb 25. PubMed PMID: 24567030; PubMed Central PMCID: PMC4078660.
  52. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis.Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti NP, Slusher BS, Stockwell BR. Elife. 2014 May 20;3:e02523. doi: 10.7554/eLife.02523. PubMed PMID: 24844246; PubMed Central PMCID: PMC4054777.
  53. MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain.He SQ, Li Z, Chu YX, Han L, Xu Q, Li M, Yang F, Liu Q, Tang Z, Wang Y, Hin N, Tsukamoto T, Slusher B, Tiwari V, Shechter R, Wei F, Raja SN, Dong X, Guan Y.  Pain. 2014 Mar;155(3):534-44. doi: 10.1016/j.pain.2013.12.008. Epub 2013 Dec 11. PubMed PMID: 24333779; PubMed Central PMCID: PMC3945061.
  54. Reply: To PMID 23722610. Gamaldo CE, Gamaldo A, McArthur JC, Smith MT. J Acquir Immune Defic Syndr. 2014 Mar 1;65(3):e124-5. doi: 10.1097/QAI.0000000000000042. PubMed PMID: 24157912; PubMed Central PMCID: PMC3945067.
  55. δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors. Ferraris DV, Majer P, Ni C, Slusher CE, Rais R, Wu Y, Wozniak KM, Alt J, Rojas C, Slusher BS, Tsukamoto T. J Med Chem. 2014 Jan 9;57(1):243-7. doi: 10.1021/jm401703a. Epub 2013 Dec 27. PubMed PMID: 24354364; PubMed Central PMCID: PMC3932958.
  56. Molecular mechanisms of 5-HT(3) and NK(1) receptor antagonists in prevention of emesis. Rojas C, Raje M, Tsukamoto T, Slusher BS.  Eur J Pharmacol. 2014 Jan 5;722:26-37. doi: 10.1016/j.ejphar.2013.08.049. Epub 2013 Oct 31. Review. PubMed PMID: 24184669.
  57. Small molecule glutaminase inhibitors block glutamate release from stimulated microglia. Thomas AG, O'Driscoll CM, Bressler J, Kaufmann W, Rojas CJ, Slusher BS.  Biochem Biophys Res Commun. 2014 Jan 3;443(1):32-6. doi: 10.1016/j.bbrc.2013.11.043. Epub 2013 Nov 19. PubMed PMID: 24269238; PubMed Central PMCID: PMC3927782.
  58. Glutamate carboxypeptidase II inhibition behaviorally and physiologically improves pyridoxine-induced neuropathy in rats. Potter MC, Wozniak KM, Callizot N, Slusher BS.  PLoS One. 2014 Sep 25;9(9):e102936. doi: 10.1371/journal.pone.0102936. eCollection 2014. PubMed PMID: 25254647; PubMed Central PMCID: PMC4177783.
  59. Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype. Albert M, Soldan A, Gottesman R, McKhann G, Sacktor N, Farrington L, Grega M, Turner R, Lu Y, Li S, Wang MC, Selnes O. Curr Al zheimer Res. 2014;11(8):773-84. PubMed PMID: 25212916; PubMed Central PMCID: PMC4163954.
  60. MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic pain. He SQ, Li Z, Chu YX, Han L, Xu Q, Li M, Yang F, Liu Q, Tang Z, Wang Y, Hin N, Tsukamoto T, Slusher B, Tiwari V, Shechter R, Wei F, Raja SN, Dong X, Guan Y.  Pain. 2014 Mar;155(3):534-44. doi: 10.1016/j.pain.2013.12.008. Epub 2013 Dec 11. PubMed PMID: 24333779; PubMed Central PMCID: PMC3945061.
  61. Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND). Lucas CH, Calvez M, Babu R, Brown A.  Neurosci Lett. 2014 Jan 13;558:97-102. doi: 10.1016/j.neulet.2013.10.037. Epub 2013 Nov 8. PubMed PMID: 24215932; PubMed Central PMCID: PMC3880598.
  62. Molecular mechanisms of 5-HT(3) and NK(1) receptor antagonists in prevention of emesis. Rojas C, Raje M, Tsukamoto T, Slusher BS.  Eur J Pharmacol. 2014 Jan 5;722:26-37. doi: 10.1016/j.ejphar.2013.08.049. Epub 2013 Oct 31. Review. PubMed PMID: 24184669.
  63. Small molecule glutaminase inhibitors block glutamate release from stimulated microglia. Thomas AG, O'Driscoll CM, Bressler J, Kaufmann W, Rojas CJ, Slusher BS.  Biochem Biophys Res Commun. 2014 Jan 3;443(1):32-6. doi: 10.1016/j.bbrc.2013.11.043. Epub 2013 Nov 19. PubMed PMID: 24269238; PubMed Central PMCID: PMC3927782.
  64. Glutamate carboxypeptidase II inhibition behaviorally and physiologically improves pyridoxine-induced neuropathy in rats. Potter MC, Wozniak KM, Callizot N, Slusher BS.  PLoS One. 2014 Sep 25;9(9):e102936. doi: 10.1371/journal.pone.0102936. eCollection 2014. PubMed PMID: 25254647; PubMed Central PMCID: PMC4177783.
  65. Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype. Albert M, Soldan A, Gottesman R, McKhann G, Sacktor N, Farrington L, Grega M, Turner R, Lu Y, Li S, Wang MC, Selnes O. Curr Alzheimer Res. 2014;11(8):773-84. PubMed PMID: 25212916; PubMed Central PMCID: PMC4163954.
  66. A consensus surface activation marker signature is partially dependent on human immunodeficiency virus type 1 Nef expression within productively infected macrophages. Babu R, Brown A.  Retrovirology. 2013 Dec 16;10:155. doi: 10.1186/1742-4690-10-155. PubMed PMID: 24341794; PubMed Central PMCID: PMC3883119.
  67. Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production. Chen X, Hui L, Geiger NH, Haughey NJ, Geiger JD.  Neurobiol Aging. 2013 Oct;34(10):2370-8. doi: 10.1016/j.neurobiolaging.2013.04.015. Epub 2013 May 11. PubMed PMID: 23673310; PubMed Central PMCID: PMC3706576.
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  73. Targeting the glutamatergic system for the treatment of HIV-associated neurocognitive disorders. Potter MC, Figuera-Losada M, Rojas C, Slusher BS.  J Neuroimmune Pharmacol. 2013 Jun;8(3):594-607. doi: 10.1007/s11481-013-9442-z. Epub 2013 Apr 4. Review. PubMed PMID: 23553365; PubMed Central PMCID: PMC3661915.
  74. Etravirine in CSF is highly protein bound. Nguyen A, Rossi S, Croteau D, Best BM, Clifford D, Collier AC, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Simpson D, Ellis RJ, Grant I, Capparelli E, Letendre S; CHARTER Group.  J Antimicrob Chemother. 2013 May;68(5):1161-8. doi: 10.1093/jac/dks517. Epub 2013 Jan 20. PubMed PMID: 23335197; PubMed Central PMCID: PMC3625433.
  75. Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders. Morgan EE, Woods SP, Letendre SL, Franklin DR, Bloss C, Goate A, Heaton RK, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Ellis RJ, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Grant I, Vaida F, Clifford DB; CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Group. J Neurovirol. 2013 Apr;19(2):150-6. doi: 10.1007/s13365-013-0152-3. Epub 2013 Feb 14. PubMed PMID: 23408335; PubMed Central PMCID: PMC3668779.
  76. The spatial relationship between neurons and astrocytes in HIV-associated dementia. Roberts ES, Chana G, Nguyen TB, Perera G, Landau S, Rabe-Hesketh S, Glass JD, McArthur J, Everall IP.  J Neurovirol. 2013 Apr;19(2):123-30. doi: 10.1007/s13365-013-0149-y. Epub 2013 Feb 21. PubMed PMID: 23430713.
  77. Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration. Croteau D, Rossi SS, Best BM, Capparelli E, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Grant I, Letendre S; CHARTER Group. J Antimicrob Chemother. 2013 Mar;68(3):684-9. doi: 10.1093/jac/dks441. Epub 2012 Nov 9. PubMed PMID: 23143899; PubMed Central PMCID: PMC3566670.
  78. Use of a glycolipid inhibitor to ameliorate renal cancer in a mouse model. Chatterjee S, Alsaeedi N, Hou J, Bandaru VV, Wu L, Halushka MK, Pili R, Ndikuyeze G, Haughey NJ. PLoS One. 2013 May 9;8(5):e63726. doi: 10.1371/journal.pone.0063726. Print 2013. PubMed PMID: 23671696; PubMed Central PMCID: PMC3650082.
  79. Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study. Mielke MM, Maetzler W, Haughey NJ, Bandaru VV, Savica R, Deuschle C, Gasser T, Hauser AK, Gräber-Sultan S, Schleicher E, Berg D, Liepelt-Scarfone I.  PLoS One. 2013 Sep 18;8(9):e73094. doi: 10.1371/journal.pone.0073094. eCollection 2013. PubMed PMID: 24058461; PubMed Central PMCID: PMC3776817.
  80. HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors. Rumbaugh JA, Bachani M, Li W, Butler TR, Smith KJ, Bianchet MA, Wang T, Prendergast MA, Sacktor N, Nath A.  Neurobiol Dis. 2013 Jan;49:169-76. doi: 10.1016/j.nbd.2012.08.013. Epub 2012 Aug 25. PubMed PMID: 22940423; PubMed Central PMCID: PMC3556339.
  81. Regulation of Glutamate Synthesis Via Inhibition of Glutamate Carboxypeptidase II (GCPII): An Effective Method to Treat Central and Peripheral Nervous System Disorders.
    Cavaletti G, Slusher B.
    Curr Med Chem. 2012 Feb 3. [Epub ahead of print] No abstract available. PMID: 22304705
  82. Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
    Le A, Lane AN, Hamaker M, Bose S, Gouw A, Barbi J, Tsukamoto T, Rojas CJ, Slusher BS, Zhang H, Zimmerman LJ, Liebler DC, Slebos RJ, Lorkiewicz PK, Higashi RM, Fan TW, Dang CV.
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  83. Subcortical brain atrophy persists even in HAART-regulated HIV disease
    Becker JT, Sanders J, Madsen SK, Ragin A, Kingsley L, Maruca V, Cohen B, Goodkin K, Martin E, Miller EN, Sacktor N, Alger JR, Barker PB, Saharan P, Carmichael OT, Thompson PM; Multicenter AIDS Cohort Study
    Brain Imaging Behav. 2011 Jan 25. [Epub ahead of print] PMID: 2126455
  84. Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease
    Lee MH, Wang T, Jang MH, Steiner J, Haughey N, Ming GL, Song H, Nath A, Venkatesan A. 
    Neurobiol Dis. 2011 Mar;41(3):678-87. Epub 2010 Dec 10. PMID: 21146610
  85. Decreased brain Glx levels in HIV dementia: a 3 tesla MR spectroscopy study
    Mohamed, M.A., Barker, P.B., Skolasky, R.L., Moxley, R.T., Pomper, M.G., Sacktor, N.C. 
    MRI 2010;1251-1257.
  86. Mitochondrial dysfunction in distal axons contribute to HIV sensory neuropathy
    Lehmann, H.C., Chen, W., Borzan, J., Mankowski, J. and Höke, A 
    Ann Neurol 2010 [Epub ahead of print]
  87. Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss
    Mielke MM, Haughey NJ, Ratnam Bandaru VV, Schech S, Carrick R, Carlson MC, Mori S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG.
    Alzheimers Dement. 2010. 6(5):378-385.
  88. Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus
    Mielke MM, Bandaru VV, McArthur JC, Chu M, Haughey NJ.
    J Neurovirol. 2010 16(6):445-45
  89. GPI-1046 Increases Presenilin-1 Expression and Restores NMDA Channel Activity
    Steiner JP, Payne KB, Main CD, D'Alfonso S, Jacobsen KX, Hicks TP, Staines WA, Poulter MO.* 
     Can J Neurol Sci. 37(4):457-67, 2010
  90. Cross-linking of human cytochrome P450 2B6 to NADPH-cytochrome P450 reductase: Identification of a potential site of interaction
    Bumpus, N.N. and Hollenberg P.F.
    Journal of Inorganic Biochemistry 2010 104(4):485-8. PMID: 20096935
  91. Serum sphingomyelins and ceramides are early predictors of memory impairment
    Mielke, M.M., Bandaru, V.V.R., Haughey, N., Rabins, P.V., Lyketsos, C.G. Carlson, M.C. 
    Neurobiology of Aging 2010 31(1):17-24.
  92. Blood-based biomarkers of microvascular pathology in Alzheimer’s disease
    Ewers, M., Mielke, M.M., Hampel, H.   
    Experimental Gerontology 2010 45(1): 75-79
  93. Plasma ceramides are altered in MCI and predict cognitive decline and hippocampal volume loss
    Mielke, M.M.,  Haughey, N., Bandaru, V.V.R., Schech, S., Carrick, R., Carlson, M.C., Mori, S., Miller, M.I., Ceritoglu, C., Brown, T., Albert, M., Lyketsos, C.G. 
    Alzheimer's & Dementia. 2010 6(5): 378-385.
  94. The 32-year relationship between cholesterol and dementia from mid- to late-life
    Mielke, M.M., Zandi, P., Shao, H., Waern, M.,  Östling, S., Guo, X., Bjorkelund, C., Lissner, L., Skoog, I., Gustafson, D.R.
    Neurology. 2010 75: 1888-1895.
  95. Low atazanavir concentrations in cerebrospinal fluid.
    Best BM, Letendre SL, Brigid E, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Ellis R, Capparelli EV, Grant I; CHARTER Group.
    AIDS. 2009 Jan 2; 23(1):83-7. PMID: 19050389. 
  96. Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection.
    Valcour V, Yeh TM, Bartt R, Clifford D, Gerschenson M, Evans SR, Cohen BA, Ebenezer GJ, Hauer P, Milllar L, Gould M, Tran P, Shikuma C, Souza S, McArthur, JC; AIDS Clinical Trials Group (ACTG) 5157 Protocol Team.
    HIV Medicine. 2009 Feb;10(2):103-10. PMID: 19200173. 
  97. GPI-1046 protects dorsal root ganglia from gp120-induced axonal injury by modulating store-operated calcium entry 
    Höke A., Morris M., and Haughey N.J.
    J Peripher Nerv Syst. Vol: 14(1); pp: 27-35
  98. Use of a macrophage-tropic GFP-tagged human immunodeficiency virus type 1 (HIV-1) to study viral reservoirs. 
    Brown AM.
    Methods Mol Biol. 2009;515:165-75.  PMID: 19378134
  99. Protease activated receptor signaling is required for African typanosome traversal of human brain microvascular endothelial cells. 
    Grab, D, Garcia-Garcia, J. C., Nikolskaia, O V., Kim, Y. V., Brown, A., Pardo, C. A., Zhang, Y., Becker, K. G., Wilson, B. A., de A Lima, A P., Scharfstein, J., and J. S. Dumler.
    PLOS Neglected Tropical Diseases 2009: 3(7): e479.
  100. Imaging serotonergic transmission with [(11)C]DASB-PET in depressed and non-depressed patients infected with HIV. 
    Hammoud DA, Endres CJ, Hammond E, Uzuner O, Brown A, Nath A, Kaplin AI, Pomper MG. 
    Neuroimage. 2009 Oct 21. [Epub ahead of print]  PMID: 19853044
  101. Role of Tat protein in HIV neuropathogenesis. 
    Li W, Li G, Steiner J, Nath A.
    Neurotox Res. 2009 Oct;16(3):205-20. Epub 2009 Mar 21. PMID: 19526283
  102. The Challenge of Follow-on Biologics for Treatment of Multiple Sclerosis.. 
    Reingold, S.C., Steiner, J.P., Polman, C.H., Cohen, J.A., Freedman, M.S., Kappos, L., Thompson, A.J. and Wolinsky, J.S.
    Neurology 2009 73, 552-559,
  103. Enhanced interaction between Hsp90 and raptor regulates mTOR signaling upon T cell activation. 
    Delgoffe GM, Kole TP, Cotter RJ, Powell JD.
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  104. Side chain specificity of ADP-ribosylation by a sirtuin. 
    Fahie K, Hu P, Swatkoski S, Cotter RJ, Zhang Y, Wolberger C
    FEBS J. 2009 Epub ahead of print. PMID 19895577, PMCID 2805772.
  105. Regionally-Specific Diffusion Tensor Imaging in Mild Cognitive Impairment and Alzheimer’s Disease. 
    Mielke, M.M., Kozauer, N.A., Chan, G.K.C., George, M., Toroney, J., Zerrate, M., Bandeen-Roche, K., Wang, M-C., vanZijl, P., Pekar, J.J., Mori, S., Lyketsos, C.G., Albert, M.
    NeuroImage 2009 46(1): 47-55.
  106. Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system.
    Letendre S, Marquie-Beck J, Capparelli E, Best B, Clifford D, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Simpson D, Grant I, Ellis RJ; CHARTER Group.
    Arch Neurol. 2008 Jan;65(1):65-70. PMID 18195140
  107. Cytokine Genotype Suggests a Role for Inflammation in Nucleoside Analog-Associated Sensory Neuropathy (NRTI-SN) and Predicts an Individual’s NRTI-SN Risk
    Cherry CL, Rosenow A, Affandi JS, McArthur JC, Wesselingh SL, Price P.
    AIDS Res Hum Retroviruses Feb 2008.
  108. Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.
    Keele BF, Tazi L, Gartner S, Liu Y, Burgon TB, Estes JD, Thacker TC, Crandall KA, McArthur JC, Burton GF.
    J Virol. 2008 Jun; 82(11):5548-61. Epub 2008 Apr;2. PMID: 18385252.
  109. Converging roles of sphingolipids and cell stress in the progression of Neuro-AIDS.
    Haughey NJ, Steiner J, Nath A, McArthur JC, Sacktor N, Pardo C, Venkata V, Bandaru R.
    Frontiers in Bioscience. 2008;13:5120-5130. PMID: 18508574
  110. Characterization of the Follicular Dendritic Cell Reservoir of Human Immunodeficiency Virus Type 1
    Keele BF, Tazi L, Gartner S, Liu Y, Burgon TB, Estes JD, Thacker TC, Crandall KA, McArthur JC, Burton GF.
    Jrnl of Virol.June 2008;82 (11):5548-5561
  111. Neurologic disorders are prevalent in HIV-positive outpatients in the Asia-Pacific region
    Wright E, Brew B, Arayawichanont A, Robertson K, Samintharapanya K, Kongsaengdao S, Lim M, Vonthanak S, Lal L, Sarim C, Huffam S, Li P, Lewis IJ, Lun WH, Kamarulzaman A, Tau G, Ali ST, Kishore K, Bain MP, Dwyer R, McCormack G, Hellard M, Cherry C, McArthur JC, Wesselingh S.
    NeurologyJuly 2008;71: 50-56.
  112. Humanimmunodeficiency virus protease inhibitors and risk for peripheral neuropathy.
    Ellis RJ, Marquie-Beck J, Delaney P, Alexander T, Clifford DB, McArthur JC, Simpson DM, Ake C, Collier AC, Gelman BB, McCutchan JA, Morgello S, Grant I; CHARTER Group.
    Ann Neurol. 2008 Nov; 64(5):566-72. PMID: 19067367.
  113. Simplification of the research diagnosis of HIV-associated sensory neuropathy.
    Evans SR, Clifford DB, Kitch DW, Goodkin K, Schifitto G, McArthur JC, Simpson DM.
    HIV Clin Trials. 2008 Nov-Dec; 9(6):434-9. PMID: 19203909.
  114. Converging roles for sphingolipids and cell stress in the progression of neurological dysfunction in AIDS
    Haughey, N.J., Steiner, J.,Nath, A. , J.C., Sacktor, N., Pardo, C., Bandaru, V.V.R.
    Frontiers in Biosci. 2008 1;13: 5120-5130.
  115. Nitrosative stress with HIV dementia causes decreased L-prostaglandin D synthetase activity.
    Li, W., Malpica, T., Gundry, R., Cotter, R., Sacktor, N., McArthur, J., Nath, A.
    Neurology 2008;70:1753-1762. PMID: 18077799
  116. Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications
    Hollenberg PF, Kent UM, Bumpus N.N.
    Chemical Research in Toxicology 2008;21(1):189-205. PMID: 18052110
  117. Investigation of the mechanisms underlying the effects of the K262R mutation of P450 2B6 on catalytic activity
    Bumpus, N.N. and Hollenberg P.F.
    Molecular Pharmacology 2008;74(4):990-9. PMID: 18621926
  118. Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: The Women’s Health and Aging Study II
    Mielke, M.M., Xue, Q-L, Zhou, J., Chaves, P.H.M., Fried, L.P., Carlson, M.C.
    Journal of Gerontology: Medical Science 2008;63:619-624.
  119. Developing new treatments for Alzheimer’s disease: The who, what, when, and how of biomarker guided therapies
    Lyketsos, C.G., Szekely, C.A., Mielke, M.M., Rosenberg P.B., Zandi, P.P.
    International Psychogeriatrics 2008; 20(5):871-89.
  120. Developing neuroprotective strategies for treatment of HIV-associated neurocognitive dysfunction.
    Rumbaugh JA, Steiner J, Sacktor N, Nath A.
    Futur HIV Ther. 2008;2(3):271-280. PMID: 19774095
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    Haughey, N.J.*, Steiner, J.P.*, Nath, A., McArthur, J.C., Sacktor, N, Pardo, C. and Veera Venkata Ratnam Bandaru.
    Frontiers in Bioscience May 2008 5120-30.
  122.  NMDA receptor activation by HIV-Tat protein is Clade-Dependent.
    Li, W., Haung, Y., Reid, R., Steiner, J., Malpic-Llanos, T., Darden, T., Shankar, S., Mahadevan, A., Satishchandra, P., and Nath, A.*
    J. Neurosci. 28(47):12190-8, 2008 (Accepted Sept 22, 2008). PMID: 19020013
  123. Brain-derived human immunodeficiency virus-1 Tat exerts differential effects on LTR transactivation and neuroimmune activation
    Boven, LA, Noorbakhsh F, Bouma G, van der Zee R, Vargas DL, Pardo C, McArthur JC, Nottet HS, Power C.
    Journal of Neurovirology. 13(2): 173-184, Apr 2007. PMID: 17505986
  124. Factors in AIDS dementia complex trial design: results and lessons from the abacavir trial
    Brew BJ, Halman M, Catalan J, Sacktor N, Price RW, Brown S, Atkinson H, Clifford DB, Simpson D, Torres G, Hall C, Power C, Marder K, McArthur JC, Symonds W, Romero C.  
    PLoS Clin Trials. 2007 Mar 30;2(3):e13. PMID: 17401456
  125. Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection
    Chase AJ, Sedaghat AR, German JR, Gama L, Zink MC, Clements JE, Siliciano RF.  
    J Virol. 2007 Dec;81(23):12748-57. Epub 2007 Sep 12. J Virol. 2007 Dec;81(23):12748-57. Epub 2007 Sep 12.  PMID:  17855517
  126. Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statins
    Chauhan A, Hahn S, Gartner S, Pardo CA, Netesan SK, McArthur J, Nath A. 
    FASEB J. 2007 Mar;21(3):777-89. Epub 2006 Dec 28. PMID: 17197385
  127. CUGBP1 is required for IFNbeta-mediated induction of dominant-negative CEBPbeta and suppression of SIV replication in macrophages
    Dudaronek JM, Barber SA, Clements JE. 
    J Immunol. 2007 Dec 1;179(11):7262-9.  PMID: 18025168
  128. Assessment of epidermal nerve fibers: a new diagnostic and predictive tool for peripheral neuropathies
    Ebenezer GJ, Hauer P, Gibbons C, McArthur JC, Polydefkis M.
    Journal of Neuropathology and Experimental Neurology. 66: 1059-1073, 2007. Review.  PMID: 18090915
  129. Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies
    Ebenezer GJ, McArthur JC, Thomas D, Murinson B, Hauer P, Polydefkis M, Griffin JW.
    Brain. 130: 2703-2714, 2007.  PMID: 17898011
  130. HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes
    Eugenin EA, King JE, Nath A, Calderon TM, Zukin RS, Bennett MV, Berman JW.  
    Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3438-43. Epub 2007 Feb 21.  PMID: 17360663
  131. Selegiline transdermal system (STS) for HIV-associated cognitive impairment: open-label report of ACTG 5090
    Evans SR, Yeh TM, Sacktor N, Clifford DB, Simpson D, Miller EN, Ellis RJ, Valcour V, Marra CM, Millar L, Schifitto G; AIDS Clinical Trials Group and the Neurologic AIDS Research Consortium. 
    HIV Clin Trials. 2007 Nov-Dec;8(6):437-46. HIV Clin Trials. 2007 Nov-Dec;8(6):437-46.  PMID: 18042509
  132. Impaired reinnervation in HIV infection following experimental denervation
    Hahn K, Triolo A, Hauer P, McArthur JC, Polydefkis M.
    Neurology. 68(16), 1251-1256, Apr 17 2007.  PMID: 17438214
  133. HIV-1 neuropathogenesis: glial mechanisms revealed through substance abuse
    Hauser KF, El-Hage N, Stiene-Martin A, Maragos WF, Nath A, Persidsky Y, Volsky DJ, Knapp PE.
    J Neurochem. 2007 Feb;100(3):567-86. Epub 2006 Dec 1.
  134. Pathogenesis of simian immunodeficiency virus-induced alterations in macaque trigeminal ganglia
    Laast VA, Pardo CA, Tarwater PM, Queen SE, Reinhart TA, Ghosh M, Adams RJ, Zink MC, Mankowski JL.
    J Neuropathol Exp Neurol. 2007 Jan;66(1):26-34. PMID: 17204934
  135. The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system
    Letendre SL, Marquie-Beck J, Ellis RJ, Woods SP, Best B, Clifford DB, Collier AC, Gelmann BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson D, Alexander TJ, Durelle J, Heaton R, Grant I; CHARTER Group.
    Journal of Neuroimmune Pharmacology. 2 (1): 120-127, Mar 2007. Epub 2007 Jan 3.  PMID: 18040835
  136. Characterization of human immunodeficiency virus (HIV)-infected cells in infiltrates associated with CNS opportunistic infections in patients with HIV clade C infection
    Mahadevan A, Shankar SK, Satishchandra P, Ranga U, Chickabasaviah YT, Santosh V, Vasanthapuram R, Pardo CA, Nath A, Zink MC. 
    J Neuropathol Exp Neurol. 2007 Sep;66(9):799-808. PMID: 17805010
  137. The SIVmac239 Pr55Gag isoform, SIV p43, suppresses proteolytic cleavage of Pr55Gag
    Nicholson MG, Barber SA, Clements JE. 
    Virology. 2007 Mar 30;360(1):84-91. Epub 2006 Nov 7.  PMID:  17092530
  138. Oxidative stress and toxicity induced by the nucleoside reverse transcriptase inhibitor (NRTI)--2',3'-dideoxycytidine (ddC): relevance to HIV-dementia
    Opii WO, Sultana R, Abdul HM, Ansari MA, Nath A, Butterfield DA.  
    Exp Neurol. 2007 Mar;204(1):29-38. Epub 2006 Oct 25. PMID: 17069802
  139. Biomarkers of HIV-1 CNS infection and injury
    Price RW, Epstein LG, Becker JT, Cinque P, Gisslen M, Pulliam L, McArthur JC.
    Neurology. 69 (18): 1781-1788. Oct 30 2007. Review.  PMID:  17967994
  140. Nucleoside reverse transcriptase inhibitors and human immunodeficiency virus proteins cause axonal injury in human dorsal root ganglia cultures
    Robinson B, Li Z, Nath A.
    J Neurovirol. 2007 Apr;13(2):160-7.  PMID: 17505984
  141. Neuropsychological test profile differences between young and old human immunodeficiency virus-positive individuals
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