Core Mission

Cognitive impairment in HIV-infected individuals remains a significant problem despite antiretroviral therapy. Biomarker discovery coupled with demographic, clinical, psychiatric, and cognitive testing data provides a powerful approach to identify putative mechanisms for cognitive dysfunction in people living with HIV. Ultimately these biomarkers may be used to predict cognitive impairment and to monitor the effects of interventional therapies in people living with HIV.

Core Resources

Available services:

• Targeted lipid and metabolite analysis: Fully quantitative targeted analysis of most lipids and metabolites detected in untargeted approaches:
  • Quantitative analysis of lipids
  • Untargeted semiquantitative analysis of lipid species
  • Endogenous metabolites
• MULTI-ARRAY immunoassay systems
• Computational Analyses
  • Machine Learning
    • Linear Regression
    • Logistic Regression
    • Decision Tree
    • Naïve Bayes
    • K-Nearest Neighbors
    • Support Vector Machine
    • K-Means
    • Random Forest
    • Dimensional Reduction Algorithms
    • Gradient Boosting Algorithms
  • PLS modeling 
• Pharmacokinetic/Pharmacodynamic analysis of potential drugs and drug metabolites.

Associated Services:

• JHU Center For AIDS Research: Clinical Laboratory Core
• Mass Spectrometry and Proteomics Core

Core Members

Robert Norman Cole, M.S., Ph.D.

Assistant Professor of Biological Chemistry
Director, Mass Spectrometry and Proteomics Facility

 

Norman James Haughey, Ph.D.

Professor of Neurology
Joint Appointment in Psychiatry and Behavioral Sciences
Vice Chair for Research, Department of Neurology

 

Leah Rubin, M.A., M.P.H., Ph.D.

Associate Professor of Neurology
Associate Professor of Psychiatry and Behavioral Sciences