The Clinical Core provides a service for both JHU and outside institutions, and it is a shared resource for translating potential interventions from the bench to the patient with a goal of improving the mental health of individuals with HIV infection. This Core provides the support necessary to evaluate novel clinical and laboratory outcome measures of CNS function through the maintenance and continued recruitment of a cohort of well-characterized HIV+ and matched HIV- seronegative (HIV-) subjects from the Baltimore/Washington, DC area representative of the local epidemic’s demographics.
- Clinical Outcomes Cohort: Cohort participants provide a source of plasma/serum and cerebrospinal fluid (CSF) specimens which will be linked to well characterized indices of cognitive impairment and used to examine markers of cell stress, neuronal injury/protection, oxidative stress, energy metabolism, immune activation and glutamate regulation in collaboration with the Biomarker Core and Therapeutic Core as well as a source for specimens for use by other institutions.
- Clinical assessments: The Core can provide validated test batteries critical for rapid development of clinical trials of novel therapeutic agents for the treatment of HIV-associated cognitive disorders.
- Data infrastructure: The Core provides analysis of clinical data and provides statistical support for all Center activities and our collaborators. The goal is to allow for efficient querying of clinical and laboratory data.
- Johns Hopkins Clinical and Translational Research
- Multicenter AIDS Cohort Study (MACS)
- Women’s Interagency HIV Study (WIHS)
- The AIDS Clinical Trial Group (ACTG)
- National NeuroAIDS Tissue Consortium (NNTC)
- AIDS Linked to the Intravenous Experience (ALIVE)
- Older Women Embracing Life (OWEL)
- Center for AIDS Research at Johns Hopkins (CFAR)
Associate Professor of Neurology
Associate Director, Neurological Consultation Service
Associate Professor of Physical Medicine and Rehabilitation
Director, Spine Outcomes Research Center