I Want To...
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
School of Medicine
I Want to...
Understanding How Myelin Protects Axons
Myelin is wrapped around axons (nerves) and serves to protect the nerves and to enhance nerve transmission. Myelin, as well as the underlying axon, is a target of damage in MS. Myelin is made up of fats and proteins. We continue to study how a myelin protein, called MAG, and a newly identified cousin, called Netrin, can communicate with the axon (nerve fiber) and protect it from damage (Nguyen et al J. Neuroscience, 2009).
Understanding how myelin protects axons could lead to novel ways of protecting or repairing nerves without necessarily having to make new myelin. This research is now unraveling the molecular details of how this crosstalk between MAG and axons occurs. Collaborators in this work include Dr. Peter Calabresi.
MAG (top row) prevents axonal degeneration that ensues overtime as seen in the control (lower row).
Request an Appointment
Adult Neurology: 410-955-9441
Pediatric Neurology: 410-955-4259
Adult Neurosurgery: 410-955-6406
Pediatric Neurosurgery: 410-955-7337
Already a Patient?
Traveling for Care?
Whether you're crossing the country or the globe, we make it easy to access world-class care at Johns Hopkins.