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Genetic Mutation Found in Familial Transverse Myelitis

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Genetic Mutation Found in Familial Transverse Myelitis

Genetic Mutation Found in Familial Transverse Myelitis

In this video, Dr. Michael Levy explains how the NMO Lab at Johns Hopkins is developing tests for TM and anti-MOG disease.

A description of a clinical trial is below.

PI Name: Michael Levy, M.D., Ph.D.

Research Study: Neuromyelitis Optica, Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Disease, Transverse Myelitis and Optic Neuritis Biorepository

IRB: IRB00094150

The neuromyelitis optica (NMO) laboratory at Johns Hopkins is developing tests for transverse myelitis (TM) and anti-myelin oligodendrocyte glycoprotein (MOG) disease. For everyone with TM or anti-MOG disease, we need a small sample. For anti-MOG disease we need blood, and for TM we need a saliva sample. These samples will be stored and used in our lab repository to develop new tests for these conditions.

If you would like to participate in these efforts, please contact us by phone (443-287-4412) or email: nmo@jhmi.edu. We will send you a consent form to review and sign that will protect your privacy. After receiving the signed form we can review your medical records for eligibility.

We are especially looking for the following.

1. anti-MOG disease: recurrent clinical events of optic neuritis and/or TM with either a negative anti-aquaporin-4 (AQP4) antibody test or a positive anti-MOG antibody test from another lab (Mayo Clinic, United Kingdom, Spain).

2. TM: a single attack of transverse myelitis, especially if a family member has TM, NMO or MS.

Full disclosure: If we successfully develop these assays, Johns Hopkins will own part of the intellectual property and can license them to companies that offer lab testing. 

Video from Dr. Levy

Genetic Mutation Found in Familial Transverse Myelitis

The NMO Lab at Johns Hopkins is developing tests for TM and Anti-MOG disease. For everyone with TM or anti-MOG we need a small sample. For Anti_MOG disease, we need blood and for TM, we need a saliva sample. These samples will be stored and used in our lab repository for the purpose of developing new tests for these conditions.