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Peripheral nerve regeneration is an incomplete and inefficient process in humans. Research in our laboratories is focusing on mechanism that underlie inefficient nerve regeneration in humans and discovering ways to promote faster and more complete nerve generation using animal models and novel biomaterials research.
Many peripheral neuropathies, but especially those caused by chemotherapy drugs, are amenable to treatment strategies that promote neuroprotection rather than nerve regeneration. Ongoing studies in our laboratories are focusing on underlying mechanisms of nerve degeneration caused by various chemotherapy drugs and diabetes. These studies are supplemented by drug discovery strategies in collaboration with the Brain Science Institute to identify new drugs that prevent nerve degeneration and bring these discoveries to clinical use.
We are currently developing ways to remove or treat the tumors of patients with neurofibromatosis while leaving the nerves intact.
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