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Clinical Trials

Currently Enrolling Research Studies in Movement Disorders

Your participation will allow you to have firsthand experience with developing new medical treatments that may be beneficial to others. Current treatment methods for neurologic disorders are only available because of volunteer participants in clinical trials. Clinical trial information is excerpted from www.clinicaltrials.gov.

Parkinson's Disease and Related Disorders

Parkinson's Progression Markers Initiative: Genetic Cohort (NA_00039232) 
Objective: Identify links to PD and learn how the LRRK2 mutation affects certain populations (Part of the Michael J. Fox Foundation Parkinson's Progression Markers Initiative)
Eligibility: Individuals of Ashkenazi Jewish descent who have a first-degree relative with PD
P.I.: Emile Moukheiber, M.D. Contact: Kori Ribb: 410-614-2216 

APL-130277 for the Acute Treatment of OFF Episodes (NA_00086593) 
Objective: Evaluate APL-130277 (sublingual version of apomorphine hydrochloride) in treatment of sudden "off time" in PD
Eligibility: Individuals with PD taking levodopa and having at least 2 hours of "off time" daily
P.I.: George Ricaurte, M.D. Contact: Kori Ribb: 410-614-2216 

Rotigotine for Anxiety in Parkinson's (NA_00092051) 
Objective: Eight-week study of rotigotine for the treatment of anxiety disorders in PD
Eligibility: Individuals diagnosed with PD experiencing anxiety
P.I.: Gregory Pontone, M.D. Contact: Kate Perepezko: 410-614-1242 

Udall Center Longitudinal Study (NA_00032761) 
Objective: Examine the relationship between the clinical symptoms of PD and the disease process in brain tissue. Participation involves eventual brain donation.
Eligibility: Individuals diagnosed with PD or atypical PD and those without a neurological diagnosis
P.I.: Liana Rosenthal, M.D. Contact: Catherine Bakker: 410-616-2814 

Udall Center Brain Donation Program (NA_00032761) 
Objective: Examine the pathological changes in the brain tissue of individuals diagnosed with PD or related disorders as compared to controls
Eligibility: Individuals diagnosed with PD or atypical PD and those without a neurological diagnosis
P.I.: Liana Rosenthal, M.D. Contact: Catherine Bakker: 410-616-2814 

Establishment of a Clinical Neuropsychological Database on Parkinson's Disease and Other Movement Disorders (NA_0001573) 
Objective: To assemble cognitive, mood and other psychological test results for use in future studies
Eligibility: All PD and ET patients seen for clinical assessment in the Division of Medical Psychology
P.I.: Jason Brandt, Ph.D. Contact: Barnett Shpritz: 410-955-1469 

Effects of Subthalamic Nucleus Deep Brain Stimulation on Decision Making in Parkinson's Disease (IRB 00078439) 
Objective: To determine whether treatment with DBS changes the perceived value of prizes and rewards, attitudes toward risk taking and other aspects of decision making
Eligibility: All PD and ET patients seen for clinical assessment in the Division of Medical Psychology
P.I.: Jason Brandt, Ph.D. Contact: Barnett Shpritz: 410-955-1469 

Exploring Mechanisms for Neuropsychiatric Symptoms of PD Using Transcranial Direct Current Stimulation (tDCS) (NA_008795) 
Objective: To study if tDCS helps depression, cognition or other non-motor PD symptoms
Eligibility: All individuals diagnosed with PD who have symptoms of depression
P.I.: Kelly Mills, M.D. Contact: Yousef Salimpour: 410-502-2666 

Investigations of Neurovascular Abnormalities in the Olfactory Cortex Using Advanced MRI Technologies (IRB00141396) 
Objective: To investigate neurovascular abnormalities in the olfactory cortex using advanced MRI techniques
Eligibility: PD patients diagnosed for more than 3 years who are able to tolerate an MRI brain scan and undergo smell and memory identification tasks
P.I.: Jun Hua, Ph.D. Contact: Adrian Paez: 443-923-9551 

Other Movement Disorders 

General Characterization: Movement Disorders (NA_000554) 
Objective: To study the genetic risk factors involved in movement disorders
Eligibility: Individuals with PD, atypical parkinsonism, dystonia, ataxia and Lewy body dementia
P.I.: Jeffrey Rothstein, M.D., Ph.D. Contact: Sonja Scholz,

4RTNI-2 (NA_00130505)
Objective and Eligibility: Select individuals with CBD, PSP or vPSP; healthy controls, caregiver component  
P.I.: Alex Pantelyat, M.D. Contact: Diane Lanham: 443-287-4156

A Randomized Controlled Trial of OnabotulinumtoxinA for Depression in Parkinson Disease (IRB00082708) 
Objective: To assess the efficacy of onabotulinumtoxinA on depression in persons with idiopathic Parkinson disease  
Eligibility: Individuals aged 18-95 years diagnosed with idiopathic PD and experiencing symptoms of depression
P.I.: Alex Pantelyat, M.D. Contact: Lavinia Rizvi

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Maryland Patients

To request an appointment, please contact the Johns Hopkins Parkinson’s Disease and Movement Disorders Center at 410-502-0133.
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