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Research

  • C. John Sperati Lab

    Research in the C. John Sperati Lab focuses on hypertension and kidney diseases. Topics of recent studies include novel treatments for these conditions, secondary hypertension and the genetic epidemiology of chronic kidney disease. Within the area of hypertension, we are particularly interested fibromuscular dysplasia, hyperaldosteronism, atherosclerotic renal arterial disease and genetic hypertensive syndromes.

    Research Areas: kidney diseases, fibromuscular dysplasia, hypertension, hyperaldosteronism, atherosclerosis

    Principal Investigator

    C. John Sperati, M.D., M.H.S.

    Department

    Medicine

  • Chirag Parikh Lab

    Dr. Parikh's research focuses on the translation and validation of novel biomarkers for the diagnosis and prognosis of acute kidney injury. Progress in kidney diseases has been hamstrung by significant heterogeneity within the current disease definitions, which are largely based on serum creatinine. Dr. Parikh's research has addressed this critical challenge by developing biomarkers of renal tubular injury, repair, and inflammation to dissect this heterogeneity. He has assembled multicenter longitudinal prospective cohorts for translational research studies across several clinical settings of acute kidney injury and chronic kidney disease for the efficient translation of novel biomarkers.

    His research is dedicated to the process of applying discoveries generated in the laboratory and in preclinical experiments, the development of clinical studies, and the design of clinical trials. Dr. Parikh's studies have refined the clinical definition in perioperative acute kidney injury and hep...atorenal syndrome, developed strategies to reduce kidney discard in deceased donor transplantation, and advanced regulatory approvals of kidney injury biomarkers. He has also developed biomarkers to identify rapid progressors of early diabetic kidney disease before derangements in serum creatinine. Dr. Parikh's research goal is to translate our understanding of pathophysiological mechanisms into clinical practice and improve the outcomes in patients with kidney disease.

    Dr. Parikh has also been the recipient of numerous honors, including the 2017 Young Investigator Award from the American Society of Nephrology.
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    Research Areas: acute kidney injury, biomarkers, Kidney Transplantation, chronic kidney disease

    Principal Investigator

    Chirag Parikh, M.B.B.S., Ph.D.

    Department

    Medicine

  • Deidra Crews Lab

    Research in the Deidra Crews Lab focuses on health disparities in chronic kidney disease. We have studied how social determinants of health, such as poverty and healthful food access, affect disparities in kidney disease outcomes. Our research on end-stage renal disease includes studies of the best timing and environment to initiate dialysis among vulnerable populations.

    Research Areas: poverty, chronic kidney disease, health disparities

    Principal Investigator

    Deidra Crews, M.D., Sc.M.

    Department

    Medicine

  • Duvuru Geetha Lab

    Research in the Duvuru Geetha Lab focuses on renal diseases in patients with systemic vasculitis as well as BK virus nephropathy in patients who have undergone renal transplant. Our studies include clinical trials on the effectiveness of rituximab versus cyclosporine in treating idiopathic membranous nephropathy and a multinational study of belimumab with azathioprine for maintaining remission of granulomatosis with polyangiitis and microscopic polyangiitis. We also have conducted research on the treatment of ANCA vasculitis, particularly in kidney transplant patients.

    Research Areas: granulomatosis with polyangiitis, kidney diseases, vasculitis, kidney transplants, Glomerulonephritis, nephrology

    Principal Investigator

    Duvuru Geetha, M.B.B.S., M.D.

    Department

    Medicine

  • Edward Kraus Lab

    The Edward Kraus Lab investigates the factors that impact the long-term success or failure of kidney transplants as well as barriers to nephrology care and transplants in minority populations. We research many topics dealing with kidney transplant rejection, including diagnostic criteria, infection risk and incompatibility factors. Our lab also has a longstanding interest in pancreas transplants and has conducted research to establish guidelines for diagnosing antibody-mediated rejection of pancreas allografts-updated Banff grading schema.

    Research Areas: kidney transplants, nephrology, health disparities, pancreas transplants

    Principal Investigator

    Edward Kraus, M.D.

    Department

    Medicine

  • Fawaz Al Ammary Lab

    Research in the Fawaz Al Ammary Lab focuses on kidney transplants, particularly clinical outcomes, patient and organ survival, and post-transplant hospital readmissions. We’re also interested in health care quality improvement.

    Research Areas: quality improvement, patient outcomes, kidney transplants

    Principal Investigator

    Fawaz Al Ammary, M.B.B.Ch.

    Department

    Medicine

  • Hamid Rabb Lab

    The Hamid Rabb Lab is involved in translational research aimed at understanding the molecular pathogenesis of kidney ischemia/reperfusion injury. We’re interested in the development of novel treatments for kidney IRI.

    Research Areas: kidney diseases, kidney ischemia/reperfusion injuries, nephrology

    Principal Investigator

    Hamid Rabb, M.D.

    Department

    Medicine

  • Michelle M. Estrella Lab

    The Michelle M. Estrella Lab conducts epidemiological and translational studies of kidney disease. We are particularly interested in HIV-related kidney disease and also study kidney injury biomarkers to determine their utility in clinical practice.

    Research Areas: epidemiology, biomarkers, kidney diseases, HIV

    Principal Investigator

    Michelle M. Estrella

    Department

    Medicine

  • Mohamed Atta Lab

    Research in the Mohamed Atta Lab focuses on kidney diseases in patients with HIV. We recently reviewed the published nephrotoxic effects of newer antiviral therapies for HIV and hepatitis C, specifically looking at the role of epithelial organic transporters in explaining renal toxicities. We also examined the relationship between the APOL1 genotype and renal histology among black patients with HIV who had undergone kidney biopsies.

    Research Areas: kidney diseases, HIV, hepatitis C

    Principal Investigator

    Mohamed Atta, M.B.B.Ch., M.D., M.P.H.

    Department

    Medicine

  • Morgan Grams Lab

    Research in the Morgan Grams Lab focuses on preventing and improving the complications associated with chronic kidney disease. Recent work includes examining the racial differences in and prognostic value of biomarkers of hyperglycemia. We’ve also developed an online tool to help identify living kidney donor candidates. The tool assesses the long-term risk of end-stage renal disease (ESRD) by weighing a variety of factors.

    Research Areas: organ donors, hyperglycemia, biomarkers, chronic kidney disease, health disparities

    Principal Investigator

    Morgan Grams, M.D., M.H.S., Ph.D.

    Department

    Medicine

Bernard Jaar, M.D.

Jaar, Bernard G., M.D., M.P.H.

Expertise, Disease and Conditions: Chronic Kidney Disease, End-Stage Kidney Disease, Hemodialysis, Peritoneal Dialysis

 

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