Gastroenterology Labs

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Ahmet Gurakar Lab

The Ahmet Gurakar Lab is interested in bioartificial liver dialysis systems and the application of total plasma exchange in the treatment of liver disorders.

Research Areas: transplants, viral hepatitis, liver diseases, plasma exchange

Principal Investigator

Ahmet Gurakar, M.D.

Department

Medicine
Alyssa Parian Lab

The Alyssa Parian Lab works to identify early markers of dysplasia. We also study inflammatory bowel disease-associated cancers, conduct IBD clinical trials and examine IBD extraintestinal manifestations.

Research Areas: inflammatory bowel disease, cancer, displaysia

Principal Investigator

Alyssa Parian, M.D.

Department

Medicine
Anthony N. Kalloo Lab

Research interests in the Anthony N. Kalloo Lab include therapeutic endoscopy, pancreatitis, sphincter of Oddi dysfunction and abdominal pain.

Research Areas: sphincter of Oddi dysfunction, endoscopy, abdominal pain, pancreatitis

Principal Investigator

Anthony Kalloo

Department

Medicine
Ashish Nimgoankar Lab

The Ashish Nimgoankar Lab is interested in translational technology development and image-guided therapies.

Research Areas: translational technology, imaging

Principal Investigator

Ashish Nimgaonkar, M.B.B.S., M.D., M.S.

Department

Medicine
Brindusa Truta Lab

The Brindusa Truta Lab studies inflammatory bowel diseases, specifically Crohn’s disease and ulcerative colitis. Recent studies defined factors associated with the development of Crohn's disease after ileal pouch anal anastomosis; determined the value of histology in identifying Lynch syndrome in early-onset of colorectal cancer patients; and compared the phenotype and genotype in adenomatous polyposis patients with and without a family history.

Research Areas: inflammatory bowel disease, Crohn’s disease, ulcerative colitis

Principal Investigator

Brindusa Truta, M.D., M.A.S.

Department

Medicine
Ellen Stein Lab

Research interests in the Ellen Stein Lab include motility disorders and esophageal diseases such as reflux disease, achalasia, Barrett's esophagus and eosinophilic esophagitis.

Research Areas: reflux disease, esophageal disease, achalasia, eosinophilic esophagitis, Barrett's esophagus, motility disorders

Principal Investigator

Ellen Stein

Department

Medicine
Eun Ji Shin Lab

Research interests in the Eun Ji Shin Lab include clinical research on obesity and the effect on GI neoplasia/malignancy.

Research Areas: gastroenterology, neoplasms, obesity

Principal Investigator

Eun Shin, M.D.

Department

Medicine
Florin Selaru Lab

Research interests in the Florin Selaru Lab comprise the molecular changes associated with the transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers. In addition, our current research—funded by the AGA, FAMRI and the Broad Foundation—works to further the understanding of cancer development and progression in the gastrointestinal tract.

Research Areas: gastroenterology, cancer, inflammation, molecular biology

Principal Investigator

Florin Selaru, M.D.

Department

Medicine
Fluorescence Imaging Core

The goal of the Fluorescence Imaging Core is to provide state-of-art light microscopy technology to the members of the Hopkins Basic Research Digestive Disease Development Center and to the whole Hopkins scientific community. Services include advanced cell and tissue multicolor imaging using Zeiss LSM-510 META, including XYZT, FREP and FRET; live cell and tissue imaging using an Olympus FV1000 MP with ratiometric ionic probes; and measurements of intracellular pH (potentially other ions) on cell populations using PTI’s RatioMaster and QuantMaster spectrofluorometic systems equipped with temperature controlled perfusion chambers.

Research Areas: imaging, light microscopy, digestive diseases

Lab Website

Principal Investigator

Olga Kovbasnjuk

Department

Medicine
Francis Giardiello Lab

Research in the Francis Giardiello Lab focuses on the study of cancer and cancer chemoprevention in the gastrointestinal tract. This has included the investigation of the genetic basis of familial colorectal cancer and the use of genetic testing in the hereditary forms of colorectal cancer. We have a continuing interest in the study of the genotypic-phenotypic correlations in polyposis syndromes, which include familial adenomatous polyposis, juvenile polyposis and Peutz-Jeghers syndrome.

Research Areas: gastrointestinal system, colorectal cancer, cancer, genomics, polyposis syndromes

Principal Investigator

Francis Giardiello, M.D.

Department

Medicine