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Gastroenterology Labs
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Ahmet Gurakar Lab
The Ahmet Gurakar Lab is interested in bioartificial liver dialysis systems and the application of total plasma exchange in the treatment of liver disorders.
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Alyssa Parian Lab
The Alyssa Parian Lab works to identify early markers of dysplasia. We also study inflammatory bowel disease-associated cancers, conduct IBD clinical trials and examine IBD extraintestinal manifestations.
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Anthony N. Kalloo Lab
Research interests in the Anthony N. Kalloo Lab include therapeutic endoscopy, pancreatitis, sphincter of Oddi dysfunction and abdominal pain.
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Ashish Nimgoankar Lab
The Ashish Nimgoankar Lab is interested in translational technology development and image-guided therapies.
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Brindusa Truta Lab
The Brindusa Truta Lab studies inflammatory bowel diseases, specifically Crohn’s disease and ulcerative colitis. Recent studies defined factors associated with the development of Crohn's disease after ileal pouch anal anastomosis; determined the value of histology in identifying Lynch syndrome in early-onset of colorectal cancer patients; and compared the phenotype and genotype in adenomatous polyposis patients with and without a family history.
Principal Investigator
Department
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Ellen Stein Lab
Research interests in the Ellen Stein Lab include motility disorders and esophageal diseases such as reflux disease, achalasia, Barrett's esophagus and eosinophilic esophagitis.
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Eun Ji Shin Lab
Research interests in the Eun Ji Shin Lab include clinical research on obesity and the effect on GI neoplasia/malignancy.
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Florin Selaru Lab
Research interests in the Florin Selaru Lab comprise the molecular changes associated with the transition from inflammatory states in the GI tract (colon, stomach, biliary tree) to frank cancers. In addition, our current research—funded by the AGA, FAMRI and the Broad Foundation—works to further the understanding of cancer development and progression in the gastrointestinal tract.
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Fluorescence Imaging Core
The goal of the Fluorescence Imaging Core is to provide state-of-art light microscopy technology to the members of the Hopkins Basic Research Digestive Disease Development Center and to the whole Hopkins scientific community. Services include advanced cell and tissue multicolor imaging using Zeiss LSM-510 META, including XYZT, FREP and FRET; live cell and tissue imaging using an Olympus FV1000 MP with ratiometric ionic probes; and measurements of intracellular pH (potentially other ions) on cell populations using PTI’s RatioMaster and QuantMaster spectrofluorometic systems equipped with temperature controlled perfusion chambers.
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Francis Giardiello Lab
Research in the Francis Giardiello Lab focuses on the study of cancer and cancer chemoprevention in the gastrointestinal tract. This has included the investigation of the genetic basis of familial colorectal cancer and the use of genetic testing in the hereditary forms of colorectal cancer. We have a continuing interest in the study of the genotypic-phenotypic correlations in polyposis syndromes, which include familial adenomatous polyposis, juvenile polyposis and Peutz-Jeghers syndrome.
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