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Allergy and Clinical Immunology

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  • Antoine Azar Lab

    The Antoine Azar Lab conducts research on topics related to primary immunodeficiency diseases, allergies and lung disease. Specifically, we explore the role of primary immunodeficiency in certain difficult-to-treat chronic lung diseases, such as COPD, emphysema and asthma.

    Research Areas: emphysema, immunology, asthma, allergies, lung disease, COPD

    Principal Investigator

    Antoine Azar, M.D.

    Department

    Medicine

  • Bradley Undem Lab

    Research in the Bradley Undem Lab centers around the hypothesis that the peripheral nervous system is directly involved in the processes of inflammation. This hypothesis is being studied primarily in the central airways and sympathetic ganglia. We are addressing this in a multidisciplinary fashion, using pharmacological, electrophysiological, biochemical and anatomical methodologies.

    Research Areas: biochemistry, electrophysiology, inflammation, pharmacology, nervous system

    Principal Investigator

    Bradley Undem, Ph.D.

    Department

    Medicine

  • Brendan J. Canning Lab

    Research in the Brendan J. Canning Lab is focused on mechanistic studies of the cough reflex. Through our work, we identified the afferent nerves that play an essential role in regulating cough. We have also been characterizing the CNS pathways regulating the cough reflex and interactions amongst various afferent nerve subtypes in regulating cough. We have identified key sites of integration of airway afferent nerve input and mechanisms by which afferent nerve subtypes act synergistically to reg...ulate cough. Our experimental approaches include electrophysiological recordings, CNS microinjection techniques, in vivo preparations for monitoring cough and reflex bronchospasm, neuronal tracing and immunohistochemistry. view more

    Research Areas: airway reflexes, coughs, immunohistochemistry

    Principal Investigator

    Brendan Canning, Ph.D.

    Department

    Medicine

  • David MacGlashan Laboratory

    Research in the Donald MacGlashan Laboratory aims to understand the regulation of secretion from human basophils and mast cells—two cells thought to play key roles in allergic reactions and other diseases. The hallmark reaction in these cells is degranulation through cell-bound IgE. Our interests lie in the signaling mechanisms that control this dramatic cell response and the factors that regulate the degree of the reaction.

    Research Areas: mast cells, allergies, basophils

    Principal Investigator

    Donald MacGlashan, M.D., Ph.D.

    Department

    Medicine

  • Jody Tversky Lab

    The Jody Tversky Lab studies dendritic cells in allergy and immunotherapy; cluster immunotherapy clinical observations and immune tolerance; and clinical diagnostic sensitivity of 10 allergy skin prick devices.

    Research Areas: allergies, immunotherapy

    Principal Investigator

    Jody Tversky, M.D.

    Department

    Medicine

  • John Schroeder Lab

    The John Schroeder Lab focuses on understanding the role human basophils and mast cells play in allergic reactions, as it relates not only to their secretion of potent inflammatory mediators (e.g., histamine and leukotriene C4) but also to their production of pro-inflammatory cytokines. We have long utilized human cells rather than cell lines in order to address the parameters, signal transduction and pharmacological aspects underlying clinically relevant basophil and mast cell responses. As a r...esult, the lab has established protocols for rapidly isolating large numbers of basophils at high purity from human blood and for growing culture-derived mast cells/basophils from human progenitor cells. A variety of assays and techniques are also in place for concurrently detecting cytokines and mediators following a wide range of stimuli. These have facilitated the in vitro testing of numerous anti-allergic drugs for inhibitory activity on basophil and mast cell activation. The lab also studies counter-regulation between the IgE and innate immune receptors on human immature dendritic cell subtypes. view more

    Research Areas: cell biology, allergies, inflammation

    Principal Investigator

    John Schroeder, Ph.D.

    Department

    Medicine

  • Johns Hopkins University Dermatology, Allergy and Clinical Immunology (DACI) Reference Laboratory

    The mission of the Johns Hopkins University Dermatology, Allergy and Clinical Immunology (DACI) Reference Laboratory is to provide comprehensive, high-quality diagnostic allergy and immunology testing to patients throughout North America with asthma, allergy and immunologic disorders. We offer an extensive menu of laboratory tests that includes allergen-specific IgE measurements to approximately 300 pollen, epidermal, mold spore, mite, food, drug, venom and occupational allergen specificities. W...e specialize in Hymenoptera (insect sting) venom-specific IgE and IgG antibody measurements. In addition, the DACI Laboratory performs hypersensitivity pneumonitis precipitin panels, serum cotinine, and environmental mold measurements. view more

    Research Areas: immunology, asthma, allergies, allergens, dermatology

    Lab Website

    Principal Investigator

    Robert Hamilton, Ph.D., M.S.

    Department

    Medicine

  • Li Gao Lab

    The Li Gao Lab researches functional genomics, molecular genetics and epigenetics of complex cardiopulmonary and allergic diseases, with a focus on translational research applying fundamental genetic insight into the clinical setting. Current research includes implementation of high-throughput technologies in the fields of genome-wide association studies (GWAS), massively parallel sequencing, gene expression analysis, epigenetic mapping and integrative genomics in ongoing research of complex lun...g diseases and allergic diseases including asthma, atopic dermatitis (AD), pulmonary arterial hypertension, COPD, sepsis and acute lung injury/ARDS; and epigenetic contributions to pulmonary arterial hypertension associated with systemic sclerosis. view more

    Research Areas: pulmonary arterial hypertension, molecular genetics, cardiopulmonary diseases, asthma, epigenetics, complex lung disease, allergies, genomics, COPD, atopic dermatitis

    Principal Investigator

    Li Gao, M.D., Ph.D.

    Department

    Medicine

  • Peisong Gao Lab

    The Peisong Gao Lab’s major focus is to understand the immunological and genetic regulation of allergic diseases. We have been involved in the identification of the genetic basis for atopic dermatitis and eczema herpeticum (ADEH) as part of the NIH Atopic Dermatitis and Vaccinia Network-Clinical Studies Consortium. Major projects in the Gao Lab include immunogenetic analysis of human response to allergen, identification of candidate genes for specific immune responsiveness to cockroach allergen,... and epigenetics of food allergy (FA). view more

    Research Areas: food allergies, eczema herpeticum, epigenetics, allergies, genomics, atopic dermatitis

    Principal Investigator

    Peisong Gao, M.D., Ph.D.

    Department

    Medicine

  • Rasika Mathias Lab

    Research in the Rasika Mathias Lab focuses on the genetics of asthma in people of African ancestry. Our work led to the first genomewide association study of its kind in 2009. Currently, we are analyzing the whole-genome sequence of more than 1,000 people of African ancestry from the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA). CAAPA’s goal is to use whole-genome sequencing to expand our understanding of how genetic variants affect asthma risk in populations o...f African ancestry and to provide a public catalog of genetic variation for the scientific community. We’re also involved in the study of coronary artery disease though the GeneSTAR Program, which aims to identify mechanisms of atherogenic vascular diseases and attendant comorbidities. view more

    Research Areas: heart disease, African Americans, asthma, genomics, health disparities

    Principal Investigator

    Rasika Mathias, Sc.D.

    Department

    Medicine

  • Sarbjit Saini Lab

    The research in the Sarbjit Saini Laboratory focuses on IgE receptor biology and IgE receptor-mediated activation of blood basophils and mast cells. We have examined the role of IgE receptor expression and activation in allergic airways disease, anaphylaxis and chronic urticaria. Our research has been supported by the NIH, American Lung Association and the AAAAI. Our current research interests have focused mechanisms of diease in allergic asthma, allergic rhinitis and also translational studies ...in chronic idiopathic urticaria. view more

    Research Areas: anaphylaxis, airway diseases, cell biology, asthma, allergies, chronic idiopathic urticaria

    Principal Investigator

    Sarbjit Saini, M.D.

    Department

    Medicine

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Bayview Internal Medicine

  • Joseph Carrese Lab

    Research in the Joseph Carrese Lab focuses on clinical ethics and professionalism, with a particular interest in medical education and examining ethical issues in the context of cultural diversity. We collaborate with colleagues to design, implement and evaluate educational curricula addressing ethics and professionalism issues in clinical practice.

    Research Areas: cultural diversity, clinical ethics, bioethics

    Principal Investigator

    Joseph Carrese, M.D., M.P.H.

    Department

    Medicine

  • Rachel Levine Lab

    The Rachel Levine Lab is interested in physician growth and well-being, best practices for advising medical students, and the experiences of women faculty and medical students in medicine.

    Research Areas: medical education, women faculty, physician well-being

    Principal Investigator

    Rachel B. Levine, M.D., M.P.H.

    Department

    Medicine

  • Robert Shochet Lab

    The Robert Shochet Lab focuses on medical education research, including the impact of learning communities on students' perceptions of the learning environment in medical school.

    Research Areas: medical education, learning communities

    Principal Investigator

    Robert Shochet

    Department

    Medicine

Cardiology

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  • Anderson Lab

    Research in the Anderson laboratory focuses on cellular signaling and ionic mechanisms that cause heart failure, arrhythmias and sudden cardiac death, major public health problems worldwide. Primary focus is on the multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII). The laboratory identified CaMKII as an important pro-arrhythmic and pro-cardiomyopathic signal, and its studies have provided proof of concept evidence motivating active efforts in biotech and the pharmaceutical... industry to develop therapeutic CaMKII inhibitory drugs to treat heart failure and arrhythmias.

    Under physiological conditions, CaMKII is important for excitation-contraction coupling and fight or flight increases in heart rate. However, myocardial CaMKII is excessively activated during disease conditions where it contributes to loss of intracellular Ca2+ homeostasis, membrane hyperexcitability, premature cell death, and hypertrophic and inflammatory transcription. These downstream targets appear to contribute coordinately and decisively to heart failure and arrhythmias. Recently, researchers developed evidence that CaMKII also participates in asthma.

    Efforts at the laboratory, funded by grants from the National Institutes of Health, are highly collaborative and involve undergraduate assistants, graduate students, postdoctoral fellows and faculty. Key areas of focus are:
    • Ion channel biology and arrhythmias
    • Cardiac pacemaker physiology and disease
    • Molecular physiology of CaMKII
    • Myocardial and mitochondrial metabolism
    • CaMKII and reactive oxygen species in asthma

    Mark Anderson, MD, is the William Osler Professor of Medicine, the director of the Department of Medicine in the Johns Hopkins University School of Medicine and physician-in-chief of The Johns Hopkins Hospital.
    view more

    Lab Website

    Principal Investigator

    Mark Anderson

  • Cammarato Lab

    The Cammarato Lab is located in the Division of Cardiology in the Department of Medicine at the Johns Hopkins University School of Medicine. We are interested in basic mechanisms of striated muscle biology.

    We employ an array of imaging techniques to study “structural physiology” of cardiac and skeletal muscle. Drosophila melanogaster, the fruit fly, expresses both forms of striated muscle and benefits greatly from powerful genetic tools. We investigate conserved myopathic (muscle disease) p...rocesses and perform hierarchical and integrative analysis of muscle function from the level of single molecules and macromolecular complexes through the level of the tissue itself.

    Anthony Ross Cammarato, MD, is an assistant professor of medicine in the Cardiology Department. He studies the identification and manipulation of age- and mutation-dependent modifiers of cardiac function, hierarchical modeling and imaging of contractile machinery, integrative analysis of striated muscle performance and myopathic processes.
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    Lab Website

    Principal Investigator

    Anthony Cammarato, Ph.D.

  • Cardiology Bioengineering Laboratory

    The Cardiology Bioengineering Laboratory, located in the Johns Hopkins Hospital, focuses on the applications of advanced imaging techniques for arrhythmia management. The primary limitation of current fluoroscopy-guided techniques for ablation of cardiac arrhythmia is the inability to visualize soft tissues and 3-dimensional anatomic relationships.

    Implementation of alternative advanced modalities has the potential to improve complex ablation procedures by guiding catheter placement, visuali...zing abnormal scar tissue, reducing procedural time devoted to mapping, and eliminating patient and operator exposure to radiation.

    Active projects include
    • Physiological differences between isolated hearts in ventricular fibrillation and pulseless electrical activity
    • Successful ablation sites in ischemic ventricular tachycardia in a porcine model and the correlation to magnetic resonance imaging (MRI)
    • MRI-guided radiofrequency ablation of canine atrial fibrillation, and diagnosis and intervention for arrhythmias
    • Physiological and metabolic effects of interruptions in chest compressions during cardiopulmonary resuscitation

    Henry Halperin, MD, is co-director of the Johns Hopkins Imaging Institute of Excellence and a
    professor of medicine, radiology and biomedical engineering. Menekhem M. Zviman, PhD is the laboratory manager.
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    Lab Website

    Principal Investigator

    Henry Halperin, M.D.

  • CORE-320 Multicenter Trial Lab

    The central theme of the CORE-320 Multicenter Trial Lab’s research is to support the Coronary Artery Evaluation Using 320-Row Multidetector CT Angiography (CORE 320) study, a multi-center multinational diagnostic study with the primary objective to evaluate the diagnostic accuracy of 320-MDCT for detecting coronary artery luminal stenosis and corresponding myocardial perfusion deficits in patients with suspected CAD compared with the reference standard of conventional coronary angiography and SP...ECT myocardial perfusion imaging.

    Armin Arbab-Zadeh, MD, PhD, is an associate professor of medicine at the Johns Hopkins University School of Medicine and Director of Cardiac Computed Tomography in the Division of Cardiology at the Johns Hopkins Hospital in Baltimore.

    Research Areas: coronary/cardiac imaging, coronary risk prediction, heart attack prevention, cardiac computed tomography, coronary circulation and disease
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  • Foster Lab

    The Foster Lab uses the tools of protein biochemistry and proteomics to tackle fundamental problems in the fields of cardiac preconditioning and heart failure. Protein networks are perturbed in heart disease in a manner that correlates only weakly with changes in mRNA transcripts. Moreover, proteomic techniques afford the systematic assessment of post-translational modifications that regulate the activity of proteins responsible for every aspect of heart function from electrical excitation to co...ntraction and metabolism. Understanding the status of protein networks in the diseased state is, therefore, key to discovering new therapies.

    D. Brian Foster, Ph.D., is an assistant professor of medicine in the division of cardiology, and serves as Director of the Laboratory of Cardiovascular Biochemistry at the Johns Hopkins University School of Medicine.


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  • Gilotra Lab

    The main focus of Dr. Gilotra's research is understanding the pathophysiology and outcomes in inflammatory cardiomyopathies including myocarditis and sarcoidosis, as well as improvement of heart failure patient care through noninvasive hemodynamic monitoring and studying novel strategies to reduce heart failure hospitalizations. Additional investigations involve clinical research in advanced heart failure therapies including heart transplantation and mechanical circulatory support. Dr. Gilotra i...s the site Principal Investigator for the NIH/NHLBI funded Heart Failure Network trials. view more

    Principal Investigator

    Nisha Gilotra, M.D.

  • Interventional Cardiology Research Group

    Our group is interested in a broad array of clinical and translational investigations spanning the evaluation of basic pathophysiology in patients undergoing cardiac procedures, development and evaluation of new therapeutic strategies, and improving patient selection and outcomes following interventional procedures. We are comprised of a core group of faculty and dedicated research nurses as well as fellows, residents, and students. Projects range from investigator-initiated single-center observ...ational studies to industry-sponsored multicenter phase 3 randomized controlled trials. We have established a database of all patients who have undergone TAVR at Johns Hopkins, which is providing the basis for several retrospective analyses and will serve as the foundation for future studies of TAVR. We are also engaged in collaborative projects with other groups from the Department of Medicine and other Departments including Cardiac Surgery, Anesthesiology, Radiology, Psychiatry, and Biomedical Engineering. Members of our group are actively involved with the Johns Hopkins Center for Bioengineering Innovation and Design (CBID) in the development of novel minimally-invasive cardiovascular devices. view more

    Principal Investigator

    Jon Resar, M.D.

  • Joseph Mankowski Lab

    The Joseph Mankowski Lab studies the immunopathogenesis of HIV infection using the SIV/macaque model. Our researchers use a multidisciplinary approach to dissect the mechanism underlying HIV-induced nervous system and cardiac diseases. Additionally, we study the role that host genetics play in HIV-associated cognitive disorders.

    Principal Investigator

    Joseph L. Mankowski, D.V.M., Ph.D.

  • Kass Lab

    Basic science investigations span an array of inquiries, such as understanding the basic mechanisms underlying cardiac dyssynchrony and resynchronization in the failing heart, and beneficial influences of nitric oxide/cGMP/protein kinase G and cGMP-targeted phosphdiesterase signaling cascades on cardiac maladaptive stress remodeling. Recently, the latter has particularly focused on the role of phosphodiesterase type 5 and its pharmacologic inhibitors (e.g. sildenafi, Viagra®), on myocyte signali...ng cascades modulated by protein kinase G, and on the nitric oxide synthase dysregulation coupled with oxidant stress.

    The lab also conducts clinical research and is presently exploring new treatments for heart failure with a preserved ejection fraction, studying ventricular-arterial interaction and its role in adverse heart-vessel coupling in left heart failure and pulmonary hypertension, and testing new drug, device, and cell therapies for heart disease. A major theme has been with the use of advanced non-invasive and invasive catheterization-based methods to assess cardiac mechanics in patients.asive and invasive catheterization-based methods to assess cardiac mechanics in patients.

    David Kass, MD, is currently the Director at the Johns Hopkins Center for Molecular Cardiobiology and a professor in cellular and molecular medicine.
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    Lab Website

    Principal Investigator

    David Kass, M.D.

  • Lima Lab

    The Lima Lab’s research is concentrated on the development and application of imaging and technology to address scientific and clinical problems involving the heart and vascular system.

    Specifically, our research is focused on developing magnetic resonance imaging (MRI) contrast techniques to investigate microvascular function in patients and experimental animals with myocardial infarction; functional reserve secondary to dobutamine stimulation and myocardial viability assessed by sodium imag...ing; and cardiac MRI and computed tomography (CT) program development of techniques to characterize atherosclerosis in humans with cardiovascular or cerebrovascular disease.

    Current projects include:
    • The Coronary Artery Risk Development in Young Adults (CARDIA) Study
    • The MESA (Multi-Ethnic Study of Atherosclerosis) Study
    • The Coronary Artery Evaluation using 64-row Multidetector Computed Tomography Angiography (CORE64) Study

    Joao Lima, MD, is a professor of medicine, radiology and epidemiology at the Johns Hopkins School of Medicine.
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    Lab Website

    Principal Investigator

    Joao Lima, M.D., M.B.A.

  • Mary Beth Brady Lab

    Research in the Mary Beth Brady Lab focuses primarily on topics within the fields of anesthesiology, imaging and cardiology. Our work has explored transesophageal echocardiography simulation, echocardiography, cardiac and vascular-thoracic anesthesiology, and other areas within critical care medicine. A recent study involved obtaining 3-D images of the heart, which were then used to build computer programs to help cardiac surgeons improve their treatment of heart defects.

    Lab Website

    Principal Investigator

    Mary Brady, M.D.

  • O'Rourke Lab

    The O’Rourke Lab uses an integrated approach to study the biophysics and physiology of cardiac cells in normal and diseased states.

    Research in our lab has incorporated mitochondrial energetics, Ca2+ dynamics, and electrophysiology to provide tools for studying how defective function of one component of the cell can lead to catastrophic effects on whole cell and whole organ function. By understanding the links between Ca2+, electrical excitability and energy production, we hope to understand ...the cellular basis of cardiac arrhythmias, ischemia-reperfusion injury, and sudden death.

    We use state-of-the-art techniques, including single-channel and whole-cell patch clamp, microfluorimetry, conventional and two-photon fluorescence imaging, and molecular biology to study the structure and function of single proteins to the intact muscle. Experimental results are compared with simulations of computational models in order to understand the findings in the context of the system as a whole.

    Ongoing studies in our lab are focused on identifying the specific molecular targets modified by oxidative or ischemic stress and how they affect mitochondrial and whole heart function.

    The motivation for all of the work is to understand
    • how the molecular details of the heart cell work together to maintain function and
    • how the synchronization of the parts can go wrong

    Rational strategies can then be devised to correct dysfunction during the progression of disease through a comprehensive understanding of basic mechanisms.

    Brian O’Rourke, PhD, is a professor in the Division of Cardiology and Vice Chair of Basic and Translational Research, Department of Medicine, at the Johns Hopkins University.
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    Lab Website

    Principal Investigator

    Brian O'Rourke, Ph.D.

  • Post Lab

    The Post Lab is involved in the Multi-Ethnic Study of Atherosclerosis (MESA), a collaborative study of the characteristics of subclinical cardiovascular disease (that is, disease detected non-invasively before it has produced clinical signs and symptoms) and the risk factors that predict progression to clinically overt cardiovascular disease or progression of the subclinical disease.

    As MESA researchers, we study a diverse, population-based sample of 6,814 asymptomatic men and women aged 45-8...4. Approximately 38 percent of the recruited participants are white, 28 percent African-American, 22 percent Hispanic, and 12 percent Asian, predominantly of Chinese descent.

    Participants were recruited from six field centers across the United States, including Johns Hopkins University. Each participant received an extensive physical exam to determine a number of conditions, including coronary calcification, ventricular mass and function, flow-mediated endothelial vasodilation, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors.

    Selected repetition of subclinical disease measures and risk factors at follow-up visits have allowed study of the progression of disease. Participants are being followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), stroke, and congestive heart failure; for cardiovascular disease interventions; and for mortality.

    Wendy S. Post, MD, MS, is an associate faculty, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, and a professor of medicine.
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    Lab Website

    Principal Investigator

    Wendy Post, M.D., M.S.

  • Retrovirus Laboratory

    Research in the Retrovirus Laboratory focuses on the molecular virology and pathogenesis of lentivirus infections. In particular, we study the simian immunodeficiency virus (SIV) to determine the molecular basis for the development of HIV CNS, pulmonary and cardiac disease.

    Research projects include studies of viral molecular genetics and host cell genes and proteins involved in the pathogenesis of disease. We are also interested in studies of lentivirus replication in macrophages and astroc...ytes and their role in the development of disease. These studies have led us to identify the viral genes that are important in neurovirulence of SIV and the development of CNS disease including NEF and the TM portion of ENV. The mechanisms of the action of these proteins in the CNS are complex and are under investigation. We have also developed a rapid, consistent SIV/macaque model in which we can test the ability of various antiviral and neuroprotective agents to reduce the severity of CNS and pulmonary disease. view more

    Principal Investigator

    Janice Clements, Ph.D.

  • The Arking Lab

    The Arking Lab studies the genomics of complex human disease, with the primary goal of identifying and characterizing genetics variants that modify risk for human disease. The group has pioneered the use of genome-wide association studies (GWAS), which allow for an unbiased screen of virtually all common genetic variants in the genome. The lab is currently developing improved GWAS methodology, as well as exploring the integration of additional genome level data (RNA expression, DNA methylation, ...protein expression) to improve the power to identify specific genetic influences of disease.

    The Arking Lab is actively involved in researching:
    • autism, a childhood neuropsychiatric disorder
    • cardiovascular genomics, with a focus on electrophysiology and sudden cardiac death (SCD)
    • electrophysiology is the study of the flow of ions in biological tissues

    Dan E. Arking, PhD, is an associate professor at the McKusick-Nathans Institute of Genetic Medicine and Department of Medicine, Division of Cardiology, Johns Hopkins University.
    view more

    Principal Investigator

    Dan Arking, Ph.D.

  • The Atlantic Cardiovascular Patient Outcomes Research Team - Atlantic C-PORT

    Our research is centered on the safety, efficacy and outcomes of PCI performed at hospitals without on-site cardiac surgery.

    Active projects:

    C-PORT Randomized Studies and Registries; New Jersey Angioplasty Demonstration Project; InCar-decision support tools for performance of PCI at hospitals without on-site cardiac surgery.

    For more information please visit Cport.org.

    Principal Investigator

    Thomas Aversano, M.D.

  • The Barouch Lab

    The Barouch Lab is focused on defining the peripheral cardiovascular effects of the adipocytokine leptin, which is a key to the understanding of obesity-related cardiovascular disease. Interestingly, many of the hormonal abnormalities seen in obesity are mimicked in heart failure. The research program will enhance the understanding of metabolic signaling in the heart, including the effects of leptin, exercise, sex hormones, and downstream signaling pathways on metabolism and cardiovascular funct...ion.

    The lab also is working to determine the precise role of the “metabolic” beta-3 adrenergic receptor (ß3AR) in the heart and define the extent of its protective effect in obesity and in heart failure, including its role in maintaining nitric oxide synthase (NOS) coupling. Ultimately, this work will enable the exploration of a possible therapeutic role of ß3AR agonists and re-coupling of NOS in preventing adverse ventricular remodeling in obesity and in heart failure.

    Lili Barouch, MD, is an associate professor of medicine in the Division of Cardiology and a member of the Advanced Heart Failure and Cardiac Transplantation group at the Johns Hopkins University School of Medicine.
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    Principal Investigator

    Lili Barouch, M.D.

  • Weiss Lab

    The Weiss Lab, which features a multi-disciplinary team at Johns Hopkins as well as at Cedars Sinai Medical Center in Los Angeles, is dedicated to identifying the most important clinical, genetic, structural, contractile and metabolic causes of sudden cardiac death as well as the means to reverse the underlying pathology and lower risk.

    Current projects include research into energy metabolism in human heart failure and creatine kinase metabolism in animal models of heart failure.

    Robert G.... Weiss, MD, is professor of medicine, Radiology and Radiological Science, at the Johns Hopkins University. view more

    Lab Website

    Principal Investigator

    Robert Weiss, M.D.

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Clinical Pharmacology

  • Brent Petty Lab

    Dr. Petty's laboratory interests focuses on antimicrobial chemotherapy, hospital-based medical practices, and internal medicine collaboration with ophthalmologic clinical trials.

    Research Areas: cancer therapies, chemotherapy, patient-centered health care, hospital-based medical practices, cancer, internal medicine

    Lab Website

    Principal Investigator

    Brent Petty, M.D.

    Department

    Medicine

  • Charles W. Flexner Laboratory

    A. Laboratory activities include the use of accelerator mass spectrometry (AMS) techniques to measure intracellular drugs and drugs metabolites. AMS is a highly sensitive method for detecting tracer amounts of radio-labeled molecules in cells, tissues, and body fluids. We have been able to measure intracellular zidovudine triphosphate (the active anabolite of zidovudine) in peripheral blood mononuclear cells from healthy volunteers given small doses of 14C-zidovudine, and have directly compared... the sensitivity of AMS to traditional LC/MS methods carried out in our laboratory.

    B. Clinical research activities investigate the clinical pharmacology of new anti-HIV therapies and drug combinations. Specific drug classes studied include HIV reverse transcriptase inhibitors, protease inhibitors, entry inhibitors (selective CCR5 and CXCR4 antagonists), and integrase inhibitors. Scientific objectives of clinical studies include characterization of early drug activity, toxicity, and pharmacokinetics. Additional objectives are characterization of pathways of drug metabolism, and identification of clinically significant harmful and beneficial drug interactions mediated by hepatic and intestinal cytochrome P450 isoforms.
    view more

    Research Areas: antiretroviral drugs, infectious disease, HIV protease inhibitors, HIV, drugs, accelerator mass spectrometry

    Principal Investigator

    Charles Flexner, M.D.

    Department

    Medicine

  • Craig W. Hendrix Lab

    Research in the Craig W. Hendrix Lab concentrates on the chemoprevention of HIV infection, clinical pharmacology of antiviral drugs, drug interactions, and oral, topical and injectable HIV microbicide development. Our lab conducts small, intensive sampling studies of PK and PD of drugs for HIV prevention with a focus on developing methods to better understand HIV and drug distribution in the male genital tract, female genital tract and lower gastrointestinal tract. We also support numerous HIV p...re-exposure prophylaxis development studies from phase I to phase III, largely as leader of the Pharmacology Core Laboratory of both the Microbicide Trial Network and HIV Prevention Trials Network. view more

    Research Areas: antiretroviral therapies, infectious disease, HIV, drugs

    Principal Investigator

    Craig W. Hendrix, M.D.

    Department

    Medicine

  • Theresa Shapiro Laboratory

    The Theresa Shapiro Laboratory studies antiparasitic chemotherapy. On a molecular basis, we are interested in understanding the mechanism of action for existing antiparasitic agents, and in identifying vulnerable metabolic targets for much-needed, new, antiparasitic chemotherapy. Clinically, our studies are directed toward an evaluation, in humans, of the efficacy, pharmacokinetics, metabolism and safety of experimental antiparasitic drugs.

    Research Areas: sleeping sickness, infectious disease, drugs, malaria, pharmacology, antiparasitic chemotherapy, molecular biology

    Principal Investigator

    Theresa Shapiro, M.D., Ph.D.

    Department

    Medicine

Endocrinology, Diabetes & Metabolism

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  • Adrian Dobs Lab

    Researchers in the Adrian Dobs Lab study topics that include gonadal dysfunction, hyperlipidemia, diabetes mellitus, and the relationship between sex hormones and heart disease. We currently are investigating male gonadal function—with particular interest in new forms of male hormone replacement therapy—and hormonal changes related to aging.

    Research Areas: diabetes mellitus, hormones, hyperlipidemia, male gonadal function, cardiovascular diseases, endocrinology

    Principal Investigator

    Adrian Dobs, M.D., M.H.S.

    Department

    Medicine

  • Aniket Sidhaye Lab

    Dr. Sidhaye is interested in improving the care of persons with cystic fibrosis, type 1 diabetes mellitus and hospitalized person with diabetes. research topics include bone health of persons with CF undergoing lung transplant, CF-related diabetes mellitus, Care of persons with type 1 diabetes mellitus transitioning from pediatrics to adult specialty clinics, Management of hospitalized persons with diabetes.

    Research Areas: biochemistry, obesity, hormones, diabetes, transitional care, endocrinology, thyroid

    Lab Website

    Principal Investigator

    Aniket Sidhaye, M.D.

    Department

    Medicine

  • David Cooper Lab

    Research in the David S. Cooper Lab focuses primarily on hyperthyroidism and thyroid cancer. Topics of recent published studies include the NTCTCS staging systems for differentiated thyroid cancer, radioiodine remnant ablation in low-risk differentiated thyroid cancer, and the link between race/ethnicity and the prevalence of thyrotoxicosis in young Americans.

    Research Areas: neoplasms, hyperthyroidism, cancer, thyroidectomy, thyroid, Graves’ disease, hypothyroidism

    Principal Investigator

    David Cooper, M.D.

    Department

    Medicine

  • Douglas Ball Lab

    The Douglas Ball Lab conducts clinical trials and pre-clinical laboratory studies of thyroid cancer. Our clinical trials, performed in collaboration with research staff in the upper aero-digestive group in the Sidney Kimmel Comprehensive Cancer Center, have included protocols for advanced radioiodine-refractory differentiated thyroid cancer and medullary thyroid cancer. Our pre-clinical research, conducted with Dr. Nelkin, Dr. Agrawal and other Kimmel Cancer Center researchers, includes pathogen...esis and mechanisms of treatment resistance in medullary thyroid cancer, and pathogenesis and immune-directed therapy of anaplastic thyroid cancer. view more

    Research Areas: thyroid cancer, medullary thyroid cancer, cancer, anaplastic thyroid cancer

    Principal Investigator

    Douglas Ball, M.D.

    Department

    Medicine

  • Gary Wand Lab

    Research conducted in the Gary Wand Lab focuses on neuropsychoendocrinology; the neurobiology of substance abuse; physiogenetics and regulation of the stress response; and the relationship between stress and chemical dependency. Current studies seek to better understand the genetic determinants of the stress response and how excessive stress hormone production contributes to neurobiological disorders, including addiction.

    Research Areas: neurobiology, substance abuse, stress, hormones, physiogenetics, neuropsychoendocrinology, alcoholism

    Principal Investigator

    Gary Wand, M.D.

    Department

    Medicine

  • Kendall Moseley Lab

    Research in the Kendall Moseley Lab is focused on the interplay between type 2 diabetes, aging and osteoporosis. We also study the function of bone stem cells in the regulation of bone remodeling.

    Research Areas: type 2 diabetes, osteoporosis, stem cells, aging

    Principal Investigator

    Kendall Moseley, M.D.

    Department

    Medicine

  • Nestoras Mathioudakis Lab

    The Nestoras Mathioudakis Lab focuses on improving patient safety and quality for hospitalized diabetes patients. Our interests include inpatient glucose management, type 2 diabetes mellitus and diabetic foot ulcers.

    Research Areas: glucose management, health care quality, safety, diabetes, diabetic foot ulcers

    Lab Website

    Principal Investigator

    Nestoras Mathioudakis, M.D., M.H.S.

    Department

    Medicine

  • Paul Ladenson Lab

    The Paul Ladenson Lab studies the application of thyroid hormone analogues for treating cardiovascular disease; novel approaches to thyroid cancer diagnosis and management; and the health economic analyses related to thyroid patient care.

    Research Areas: thyroid cancer, cardiovascular diseases, endocrinology

    Principal Investigator

    Paul Ladenson, M.D.

    Department

    Medicine

  • Rita Kalyani Lab

    Research in the Rita Kalyani Lab examines the decreased physical functioning observed in patients with diabetes as they age. Through several ongoing epidemiological cohorts, we are investigating the association of high blood glucose and high insulin levels with accelerated muscle loss, and possible contributions to the physical disability observed in diabetes. We are currently involved in clinical studies that aim to understand the underlying mechanisms for these associations and to facilitate t...he development of novel strategies to prevent muscle loss and disability in people with diabetes. view more

    Research Areas: metabolism, insulin, diabetes, cardiovascular diseases, endocrinology, blood glucose

    Principal Investigator

    Rita Kalyani, M.D., M.H.S.

    Department

    Medicine

  • Roberto Salvatori Lab

    Research in the Roberto Salvatori Lab focuses on the genetic causes of isolated growth hormone deficiency (GHD), consequences of untreated GHD, and cortisol excess and deficiency. Current work explores GHD’s relation to obesity and indicates that Cushing's syndrome may be under-recognized in patients undergoing bariatric surgery. We recently took part in a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients, a condition that has not been... studied previously in a standardized way. view more

    Research Areas: pituitary gigantism, growth hormone deficiency, hypercortisolism, endocrinology

    Principal Investigator

    Roberto Salvatori, M.D.

    Department

    Medicine

  • Sherita Golden Lab

    Research in the Sherita Golden Lab focuses on identifying endocrine risk factors associated with the development of diabetes and cardiovascular disease. We conduct our research by incorporating measures of hormonal function into the design of clinical trials of cardiovascular risk modification, observational studies of incident cardiovascular disease and diabetes, and studies evaluating diabetic complications.

    Research Areas: epidemiology, stress, hormones, diabetes, cardiovascular diseases, endocrinology

    Principal Investigator

    Sherita Golden, M.D., M.H.S.

    Department

    Medicine

  • Suzanne Jan de Beur Lab

    Researchers in the Suzanne Jan de Beur Lab are interested in bone and mineral metabolism, endocrinology and osteoporosis. In addition, we focus on hormonal regulators of phosphate homeostasis, parathyroid hormone signaling and the molecular basis of hypophosphatemic disorders.

    Research Areas: osteoporosis, metabolism, diabetes, endocrinology

    Principal Investigator

    Suzanne Jan De Beur, M.D.

    Department

    Medicine

  • Thomas W. Donner Lab

    The Thomas W. Donner Lab focuses on type 1 and type 2 diabetes, with an emphasis on the prevention of complications in patients with these conditions. We’re currently collaborating with Dr. Abdel Hamad to inhibit B-regulatory cell apoptosis through a novel monoclonal antibody that targets the probable apoptotic factor. We also lead a multi-center, international consortium of researchers studying ways to prevent type 1 diabetes and preserve insulin secretion in people who have been recently diagn...osed with the chronic condition. view more

    Research Areas: cell apoptosis, insulin, diabetes

    Principal Investigator

    Thomas Donner, M.D.

    Department

    Medicine

  • Todd Brown Lab

    The Todd Brown Lab focuses on metabolic, endocrine and skeletal abnormalities in HIV-infected patients, particularly as these factors relate to aging. Our studies take an epidemiologic approach to understanding the occurrence and prevalence of insulin resistance, diabetes, and anthropometric changes in HIV patients and their relationship to antiretroviral treatment.

    Research Areas: antiretroviral therapies, insulin resistance, metabolism, HIV, diabetes, endocrinology, skeletal abnormalities

    Principal Investigator

    Todd Brown, M.D., Ph.D.

    Department

    Medicine

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Gastroenterology & Hepatology

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General Internal Medicine

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  • Anne Monroe Lab

    Research interests of the Anne Monroe Lab include retention in HIV care and metabolic and cardiovascular complications of HIV. Recently, we examined the association between physical activity and degree of insulin resistance, and whether HIV serostatus is associated with not achieving low-density lipoprotein cholesterol (LDL-c) target, both among Multi-center AIDS Cohort Study (MACS) participants.

    Research Areas: HIV, insulin, cardiovascular diseases, cholesterol

    Principal Investigator

    Anne Monroe

    Department

    Medicine

  • Bimal Ashar Lab

    Research in the Bimal Ashar Lab focuses on preventive medicine, medical education and dietary supplements. Recent research explored medical residents' knowledge of dietary supplements and examined the reported validity and reliability of methods for evaluating continuing medical education.

    Research Areas: primary care, medical education, preventive medicine, dietary supplements

    Principal Investigator

    Bimal Ashar, M.D., M.B.A.

    Department

    Medicine

  • Christopher Chute Lab

    Work in the Christopher Chute Lab involves the management of clinical data to enable effective evidence-based clinical practice and translational research. Recently, we developed an EHR-based genetic testing knowledge base to be integrated into the genetic testing ontology (GTO) and identified potential barriers to pharmacogenomics clinical decision support (CDS) implementation.

    Research Areas: pharmacogenomics, genomics, electronic health records, bioinformatics, evidence-based medicine, phenotypes

  • Claire Snyder Lab

    Researchers in the Claire Snyder Lab study the quality of cancer care, with a special focus on two areas: the quality of life for cancer patients undergoing treatment and the coordination of care between cancer specialists and primary care providers. As part of our quality-of-life research, we're investigating the use of patient-reported outcome questionnaires in routine oncology practice as well as developing a website for collecting the questionnaires and linking them with the electronic medic...al record. As part of our cancer-survivorship research, we've conducted large database studies to identify the physician specialties involved in the care of cancer survivors and to determine how that relates to survivors receiving recommended follow-up care. We're also working with investigators in the Sydney Kimmel Comprehensive Cancer Center to develop care strategies for breast cancer survivors. view more

    Research Areas: breast cancer, cancer survivors, cancer, quality of life, care coordination

    Principal Investigator

    Claire Snyder, Ph.D., M.H.S.

    Department

    Medicine

  • Craig Pollack Lab

    Research in the Craig Pollack Lab focuses on cancer prevention and control, particularly prostate cancer. Our work aims to understand how the organization environment of health care affects the type and quality of care that patients receive. Other work investigates the broader social context of health and health care— specifically housing, financial hardship and socioeconomic status.

    Research Areas: sociodemographics, prostate, cancer, quality of care

    Principal Investigator

    Craig Pollack, M.D., M.H.S.

    Department

    Medicine

  • Daniel Brotman Lab

    Research in the Daniel Brotman Lab focuses on aspects of hospital medicine such as quality improvement, patient satisfaction and perioperative medicine. We recently conducted a cohort study of hypertensive African Americans to examine how access to care, treatment ambivalence and medication non-adherence affect long-term mortality.

    Research Areas: patient satisfaction, quality improvement, African Americans, hospital medicine

    Principal Investigator

    Daniel Brotman, M.D.

    Department

    Medicine

  • Daniel Ford Lab

    Research in the Daniel Ford Lab seeks to understand the relationships between depression and various chronic medical conditions. Recently, we've focused on depression and coronary artery disease as well as tactics for improving care for patients with medical comorbidity. Our research was among the first to document depression as a risk factor for myocardial infarction and stroke. Our team is also interested in exploring how information technology can be used to improve the care of patients with ...depression and tobacco abuse. view more

    Research Areas: coronary artery disease, tobacco use, depression, stroke, information technology, myocardial infarction

    Principal Investigator

    Daniel Ford, M.D., M.P.H.

    Department

    Medicine

  • Dhananjay Vaidya Lab

    Research conducted in the Dhananjay Vaidya Lab focuses on the prevention of heart disease, with special emphasis on cardiometabolic risk factors, genetics in high-risk families, cardiovascular epidemiology, statistics and vascular biology. We also provide consultation on study design as well as plan and oversee data analyses for projects supported by the Center for Child and Community Health Research.

    Research Areas: heart disease, epidemiology, data analysis, cardiometabolic risk factors, statistics, study design, cardiovascular, genomics, vascular biology

    Principal Investigator

    Jay Vaidya, M.B.B.S., Ph.D., M.P.H.

    Department

    Medicine

  • Edgar Miller Lab

    Research in the Edgar Miller Lab focuses on nutrition, hypertension and kidney disease. Current projects include a National Heart, Lung, and Blood Institute study on dietary carbohydrate and glycemic index effects on markers of oxidative stress, inflammation and kidney function; and a National Institute of Diabetes and Digestive and Kidney Diseases randomized controlled trial that examines the effects of omega-3 fatty acid supplementation on urine protein excretion in diabetic kidney disease.

    Research Areas: nutrition, kidney diseases, diabetes, inflammation

    Principal Investigator

    Edgar Miller, M.D., Ph.D.

    Department

    Medicine

  • Eric Bass Lab

    Work in the Eric Bass Lab focuses on evidence-based medicine, comparative effectiveness research, and community health partnerships. Our work is closely aligned with the Center for Health Services and Outcomes Research and the Johns Hopkins Evidence-Based Practice Center.

    Research Areas: clinical medicine, research methods, public health, health care policy, evidence-based medicine

    Principal Investigator

    Eric B. Bass, M.D., M.P.H.

    Department

    Medicine

  • Gail Berkenblit Lab

    The Gail Berkenblit Lab focuses on HIV testing. We are particularly interested in the training of residents as it relates to HIV outpatient care, and the development and assessment of online curriculum.

    Research Areas: medical education, HIV

    Principal Investigator

    Gail Berkenblit, M.D., Ph.D.

    Department

    Medicine

  • Gail Daumit Lab

    Research in the Gail Daumit Lab is devoted to improving overall health and decreasing premature mortality for people with serious mental illnesses, such as schizophrenia and bipolar disorder. We have conducted observational studies to determine and convey the burden of physical health problems in this vulnerable population, and are currently leading a randomized trial funded by the National Heart, Lung, and Blood Institute to test a comprehensive cardiovascular risk reduction program in people w...ith serious mental illness. view more

    Research Areas: mental health, schizophrenia, bipolar disorder, cardiovascular diseases

    Principal Investigator

    Gail Daumit, M.D., M.H.S.

    Department

    Medicine

  • Gail Geller Lab

    The Gail Geller Lab primarily conducts empirical quantitative and qualitative research on the ethical and social implications of genetic testing in the adult, pediatric and family contexts. We have focused on clinical-patient communication under conditions of uncertainty; professionalism and humanism in medical education; cross-cultural variation in concepts of health and disease; and clinician suffering and moral distress. We explore these topics in a range of health care contexts, including ge...nomics, complementary and alternative medicine (CAM) and palliative care. Our researchers have a longstanding interest in medical socialization, provider-patient communication under conditions of uncertainty and cultural differences in attitudes toward health and disease. We also explore the intersection of CAM and bioethics, as well as the role of palliative care in chronic diseases, such as muscular dystrophy and sickle cell disease. view more

    Research Areas: palliative care, patient-provider relationships, genomics, complementary and alternative medicines, bioethics

    Principal Investigator

    Gail Geller, Sc.D., M.H.S.

    Department

    Medicine

  • Geetanjali Chander Lab

    Our research focuses at the nexus of HIV and alcohol and other substance use. We examine epidemiological aspects of HIV and alcohol use/other drug use among persons with HIV (PWH), and work on the adaptation and testing of person and computer-delivered interventions for unhealthy alcohol use, particularly among women.

    Research Areas: Ressearch at the intersection of alcohol and other substance use and HIV, intervention, substance abuse, alcohol use, HIV, hepatitis C

    Principal Investigator

    Geetanjali Chander

    Department

    Medicine

  • GeneSTAR Research Program

    Research at the GeneSTAR Research Center focuses primarily on discovering and amplifying mechanisms of atherogenic vascular diseases and attendant comorbidities. We search for genetic and nongenetic factors and biological cascades that are associated with successful vascular aging and well-being. Our work includes biological, lifestyle and genetic models of both health and disease in families who are putatively at high risk for premature disease. We collect data on diet, physical activity, smoki...ng, mental stress, cognition, sociodemographic and psychological factors, as well as traditional lipid, metabolic and inflammatory biomarkers, cardiovascular and cerebrovascular phenotypes, and measures of vascular function. Our research also seeks to better understand racial disparities and translation to population-based and patient approaches to enhancing health and wellness in diverse high-risk populations. view more

    Research Areas: psychology, epidemiology, sociodemographics, metabolism, genomics, vascular diseases

    Lab Website

    Principal Investigator

    Diane Becker

    Department

    Medicine

  • Hanan Aboumatar Lab

    Research in the Hanan Aboumatar Lab focuses on advancing patient-centered outcomes through improved patient and family involvement. We also focus on multilevel methods to increase the patient-centered focus of care delivery. Recent research examined the impact of a quality-improvement intervention on patient involvement in primary care and treatment with respect and dignity in intensive care.

    Research Areas: patient-centered health care, quality improvement, safety, patient outcomes

    Lab Website

    Principal Investigator

    Hanan Aboumatar, M.D., M.P.H.

    Department

    Medicine

  • Henry Michtalik Lab

    Researchers in the Henry Michtalik Lab are interested in patient safety—particularly as it relates to patient census statistics and acute to primary care transitions—and quality improvement and systems management.

    Research Areas: primary care, health care quality, safety, internal medicine, patient census

    Principal Investigator

    Henry Michtalik, M.D., M.H.S., M.P.H.

    Department

    Medicine

  • Howard Levy Lab

    Research interests in the Howard Levy Lab center on the integration of genetics into primary care, education of non-geneticist providers about genetics, and the natural history and management of Ehlers-Danlos syndrome and related disorders of connective tissue.

    Research Areas: primary care, tissue connectivity disorders, genomics, Ehlers-Danlos syndrome

    Principal Investigator

    Howard Levy, M.D., Ph.D.

    Department

    Medicine

  • Hsin-Chieh Yeh Lab

    Work in the Hsin-Chieh Yeh Lab focuses on clinical trials and cohort studies of diabetes, obesity and behavioral intervention, cancer and hypertension. Recent investigations have focused on novel risk factors and complications related to obesity and type 2 diabetes, particularly lung function, smoking and cancer. We recently co-led a randomized clinical trial of tailored dietary advice for consumption of dietary supplements to lower blood pressure and improve cardiovascular disease risk factors ...in hypertensive urban African Americans. view more

    Research Areas: epidemiology, African Americans, cancer, obesity, hypertension, diabetes, behavioral medicine

    Lab Website

    Principal Investigator

    Hsin-Chieh Yeh, Ph.D.

    Department

    Medicine

  • Hypertension Center

    The Hypertension Center at Johns Hopkins performs clinical research to advance the science of the diagnosis and treatment of hypertension.

    Research Areas: hypertension

    Lab Website

    Principal Investigator

    Gregory Prokopowicz

    Department

    Medicine

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Geriatric Medicine & Gerontology

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  • Alicia Arbaje Lab

    Research in the Alicia Arbaje Lab aims to help older adults maintain dignity and quality of life as they age. We are particularly interested in creating health care systems to improve safety and outcomes for older adults.

    Research Areas: safety, gerontology, health care systems

    Principal Investigator

    Alicia Arbaje, M.D., Ph.D., M.P.H.

    Department

    Medicine

  • Ariel Green Lab

    Research in the Ariel Green Lab focuses on informing and improving decisions surrounding the use of invasive medical technologies for older adults with complex medical diseases. Our long-term goals are to conduct epidemiologic research, create public health initiatives, and help shape policies that improve the lives of older adults.

    Research Areas: epidemiology, health care policy, decision making, gerontology

    Principal Investigator

    Ariel R. Green, M.D., Ph.D., M.P.H.

    Department

    Medicine

  • Bruce Leff Lab

    Research interests in the Bruce Leff Lab include home hospital, guided care, medical education and long-term care.

    Research Areas: medical education, gerontology, home hospital

    Principal Investigator

    Bruce Leff, M.D.

    Department

    Medicine

  • Center on Aging and Health

    The Center on Aging and Health pursues creative approaches to solve the important health and health care problems for an aging population. Research in our center involves population-based and clinical studies of the causes, correlates, and consequences of aging-related conditions, including frailty, disability, and social isolation. We house four distinct research working groups: the Frailty and Multisystem Dysregulation Working Group; the Family and Social Resources Working Group; the Cognitive... and Sensory Functions Working Group; and the Biostatistics, Design and Analysis Working Group. We provide key infrastructure, such as the statistical data core, that supports clinical- and population-based research and education with expertise in research with older adults. view more

    Research Areas: cognition, disabilities, behavioral research, stroke, frailty, biostatistics, dementia, gerontology

    Lab Website

    Principal Investigator

    David Roth, Ph.D., M.A.

    Department

    Medicine

  • Colleen Christmas Lab

    The Colleen Christmas Lab studies geriatric medicine, with a focus on geriatric education, interventions to reduce inappropriate nursing home citations by state surveyors, nutrition and fall prevention for geriatric patients, and perioperative geriatric care.

    Research Areas: medical education, nutrition, perioperative geriatric care, fall prevention, gerontology

    Principal Investigator

    Colleen Christmas, M.D.

    Department

    Medicine

  • Cynthia Boyd Lab

    Research in the Cynthia Boyd Lab concentrates on the clinical care of comorbid chronically ill and frail older adults, both chronically and during acute illnesses. Current projects focus on the treatment burden among older adults with multimorbidity, the importance of competing risks in decision-making for the elderly, the effects of guided care on the quality of care and the improvement of clinical practice guidelines for the elderly.

    Research Areas: quality of life, comorbidity, frailty, gerontology

    Principal Investigator

    Cynthia Boyd, M.D., M.P.H.

    Department

    Medicine

  • Danelle O. Cayea Lab

    Researchers in the Danelle O. Cayea Lab develop and evaluate curriculum that teaches the care of older adults to residents and medical students. Our work includes older adults with complex heath issues who receive care in hospital and ambulatory environments.

    Research Areas: medical education, gerontology

    Principal Investigator

    Danelle Cayea, M.D., M.S.

    Department

    Medicine

  • Esther Oh Lab

    The Esther Oh Lab is interested in developing biological markers for pre-clinical stages of Alzheimer's disease (AD). Our current research involves using transgenic models of AD to develop peripheral injections of monoclonal antibodies against amyloid-beta as a tool to detect a level of amyloid-beta that would be correlative to the amyloid-beta level in the brain.

    Research Areas: amyloid-beta, dementia, Alzheimer's disease, monoclonal antibodies

    Principal Investigator

    Esther Oh, M.D., Ph.D.

    Department

    Medicine

  • Matthew McNabney Lab

    Research interests in the Matthew McNabney Lab include community-based long-term care.

    Research Areas: long-term care, gerontology

    Principal Investigator

    Matthew McNabney, M.D.

    Department

    Medicine

  • Michelle Belantoni Lab

    Research interests in the Michelle Belantoni Lab include osteoporosis screening using heel ultrasonography and quality outcomes in post-acute care settings.

    Research Areas: osteoporosis, gerontology, ultrasonography

    Principal Investigator

    Michele Bellantoni, M.D.

    Department

    Medicine

  • Older Americans Independence Center

    The Older Americans Independence Center (OAIC) studies frailty, an age-related condition in which older adults lose the capacity to cope with stressors and become vulnerable to functional decline, loss of independence and mortality. Since its original funding in 2003, the center has helped demonstrate that frailty is a syndrome caused by multiple biological mechanisms that are expressed through characteristics of decreased resiliency and reserve in older adults. The mission of OAIC is to provide... a hypothesis-driven, frailty-focused, highly interdisciplinary center where supported investigators receive the expertise, resources and training necessary to make fundamental discoveries related to the origins and causes of frailty and then move these discoveries towards frailty-focused interventions. view more

    Research Areas: frailty, gerontology, biology

    Lab Website

    Principal Investigator

    Jeremy Walston, M.D.

    Department

    Medicine

  • Peter Abadir Lab

    Research in the Peter Abadir Lab focuses on the renin-angiotensin system (RAS), a signaling pathway that regulates blood pressure and has been linked independently to both aging and inflammation. We’re particularly interested in changes in RAS that occur with aging. We also study signal transduction and the role of the crosstalk between angiotensin II receptor in aging and are interested in understanding the function of angiotensin II in the process of vascular aging.

    Research Areas: renin-angiotensin system, aging, inflammation, gerontology

    Principal Investigator

    Peter Abadir, M.D.

    Department

    Medicine

  • Pilot and Exploratory Studies Core

    The Pilot and Exploratory Studies Core supports pilot and exploratory studies related to developing effective prevention of and therapies for frailty in older adults. Our objective is to facilitate independence in older adults. We provide funding; access to biostatistical, biological and clinical research core resources; and mentoring and oversight to completion of pilot and exploratory studies.

    Research Areas: frailty, gerontology

    Lab Website

    Principal Investigator

    Neal Fedarko, Ph.D.

    Department

    Medicine

  • Qian Li Lab

    The Qian Li Lab's primary area of statistical expertise is the development and application of statistical methods for: (1) handling the truncation of information on underlying or unobservable outcomes (e.g., disability) as a result of screening, (2) missing data, including outcome (e.g., frailty) censoring by a competing risk (e.g., mortality) and (3) trajectory analysis of multivariate outcomes. Other areas of methodologic research interests include multivariate, latent variable models.

    Research Areas: epidemiology, outcomes, biostatistics

    Principal Investigator

    Qian Li

    Department

    Medicine

  • Samuel Durso Lab

    The Samuel Durso Lab researches effective education models for preparing the next generation of geriatric educators. Specifically, we have developed and evaluated the "Train the Trainer" program to prepare faculty to teach geriatric medicine.

    Research Areas: medical education, gerontology

    Principal Investigator

    Samuel Durso, M.D., M.B.A.

    Department

    Medicine

  • Sean Leng Lab

    The Sean Leng Lab studies the biology of healthy aging. Specific projects focus on chronic inflammation in late-life decline; immunosenescence and its relationship to the basic biological and physiological changes related to aging and frailty in the human immune system; and T-cell repertoire analysis.

    Research Areas: immunology, aging, inflammation, gerontology, T cells

    Principal Investigator

    Sean Leng, M.D., Ph.D.

    Department

    Medicine

  • Sevil Yasar Lab

    Research areas in the Sevil Yasar Lab include dementia, cognitive decline, hydrocephalus and pharmacoepidemiology. Recently, we studied the ability of fatty acid amide hydrolase (FAAH) inhibitors to block the rewarding effects of nicotine in squirrel monkeys.

    Research Areas: cognition, epidemiology, pharmacoepidemiology, dementia, gerontology, hydrocephalus

    Principal Investigator

    Sevil Yasar, M.D., Ph.D.

    Department

    Medicine

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Hematology

  • Alison Moliterno Lab

    The Alison Moliterno Lab studies the molecular pathogenesis of myeloproliferative disorders (MPDs), including polycythemia vera, essential thrombocytosis and idiopathic myelofibrosis. Our research is focused on the genetic and epigenetic lesions associated with MPDs, with the goal of improving diagnosis and treatment for these disorders.

    Research Areas: blood disorders, idiopathic myelofibrosis, essential thrombocytosis, epigenetics, genomics, polycythemia vera, myeloproliferative disorders

    Principal Investigator

    Alison Moliterno, M.D.

    Department

    Medicine

  • Jerry Spivak Lab

    Research in the Jerry Spivak Lab focuses on chronic myeloproliferative disorders, particularly their molecular mechanisms and methods for distinguishing them diagnostically and interventionally. By analyzing gene expression in polycythemia vera stem cells, we have learned that patients with polycythemia vera can be differentiated from those with erythrocytosis and can be diagnosed as having either aggressive or slow-growing disease. We are also studying the roles played by specific molecular markers in the pathogenesis and diagnosis of polycythemia vera.

    Research Areas: stem cells, pathogenesis, polycythemia vera, myeloproliferative disorders

    Principal Investigator

    Jerry Spivak

    Department

    Medicine

  • Linda Smith-Resar Lab

    The Linda Smith-Resar Lab primarily investigates hematologic malignancy and molecular mechanisms that lead to cancer as well as sickle cell anemia. Recent studies suggest that education is an important and effective component of a patient blood management program and that computerized provider order entry algorithms may serve to maintain compliance with evidence-based transfusion guidelines. Another recent study indicated that colonic epithelial cells undergo metabolic reprogramming during their evolution to colorectal cancer, and the distinct metabolites could serve as diagnostic tools or potential targets in therapy or primary prevention.

    Research Areas: blood disorders, sickle cell diseases, blood management programs, hematologic malignancies

    Lab Website

    Principal Investigator

    Linda Smith Resar, M.D.

    Department

    Medicine

  • Michael B. Streiff Lab

    The Michael B. Streiff Lab conducts clinical and laboratory research of thrombophilia associated with malignancy. We are interested in the application of novel coagulation assays to explore the pathogenesis of thrombosis and the development of strategies to enhance the clinical management of anti-thrombotic agents.

    Research Areas: cancer, thrombophilia

    Principal Investigator

    Michael Streiff, M.D.

    Department

    Medicine

  • Rakhi Naik Lab

    The Rakhi Naik Lab studies sickle cell disease. We focus on complications related to the disease, including chronic kidney disease and venous thromboembolism. By defining the risks and factors for diseases related to the sickle cell trait, we hope to improve genetic counseling and screening and treatment recommendations. Other research in the lab examines the epidemiology and unique mechanisms of thrombosis in patients with hemoglobin disorders. Specifically, we are trying to identify mechanisms of hypercoagulability and develop treatments for patients with hemoglobinopathies.

    Research Areas: epidemiology, sickle cell diseases, kidney diseases, venous thromboembolism, hemoglobin disorders, genetic counseling

    Principal Investigator

    Rakhi Naik, M.D., M.H.S.

    Department

    Medicine

  • Robert Brodsky Lab

    Investigators in the Robert Brodsky Lab study normal and abnormal hematopoiesis, particularly mutations of the phosphatidylinositol glycan anchor biosynthesis class A (PIG-A) gene in aplastic anemia. Our team has developed a new diagnostic assay for paroxysmal nocturnal hemoglobinuria (PNH) that is based on the toxin Aaeromonas hydrophila.

    Research Areas: high-dose cyclophosphamide, hematopoiesis, paroxysmal nocturnal hemoglobinuria, aplastic anemia

    Principal Investigator

    Robert Brodsky, M.D.

    Department

    Medicine

  • Sophie Lanzkron Lab

    Work in the Sophie Lanzkron Lab is focused on understanding the barriers to care for adults with sickle cell disease. Our research has shown that despite the approval of hydroxyurea treatment predicted to decrease hospitalizations for sickle cell disease patients' the cost of care has increased significantly in recent years. Research is ongoing to identify the factors that limit access to care for this population.

    Research Areas: sickle cell diseases, patient-centered health care, hydroxyurea, health services research

    Principal Investigator

    Sophie Lanzkron, M.D., M.H.S.

    Department

    Medicine

  • Zack Wang Lab

    The Wang lab focuses on the signals that direct the differentiation of pluripotent stem cells, such as induced-pluripotent stem (iPS) cells, into hematopoietic and cardiovascular cells. Pluripotent stem cells hold great potential for regenerative medicine. Defining the molecular links between differentiation outcomes will provide important information for designing rational methods of stem cell manipulation.

    Research Areas: pluripotent stem cells, stem cells, molecular genetics, stem cell biology, gene therapy

    Principal Investigator

    Zack Wang, Ph.D.

    Department

    Medicine

Hospital Medicine at JHBMC

  • Amy Knight Lab

    Research in the Amy Knight Lab focuses on methods by which information technology can improve the quality of health care. We investigate the role computer systems can play in expanding patient-doctor communication, streamlining healthcare tasks for both medical students and practitioners, and establishing a higher standard of care. Our studies have explored the effectiveness of semi-automating daily progress notes for improved documentation, peer assessment of professional performance among hosp...italists, ways to enable patient-centered care using information technology and other topics. view more

    Research Areas: outcomes, patient-provider relationships, internal medicine, information technology

    Principal Investigator

    Amy Knight, M.D.

    Department

    Medicine

  • Janet Record Lab

    Research in the Janet Record Lab focuses on medical education and patient-centered care. We’re currently developing a curriculum for internal medicine residents in the inpatient general medicine service setting. The curriculum teaches residents to use hand-carried ultrasound for imaging the inferior vena cava to assess volume status.

    Research Areas: medical education, patient-centered health care, imaging, internal medicine, inferior vena cava

    Principal Investigator

    Janet Record, M.D.

    Department

    Medicine

Infectious Diseases

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  • Amita Gupta Lab

    The Amita Gupta Lab focuses on drug trials to prevent and treat HIV, tuberculosis (TB) and other co-morbidities in adults, including pregnant women and children who reside in low-income settings. We also conduct cohort studies assessing HIV, inflammation and nutrition in international settings; TB in pregnancy; and risk factors for TB in India (CTRIUMPH). We collaborate with several faculty in the Center for TB Research, Division of Infectious Diseases and the School of Public Health.

    Research Areas: global health, nutrition, infectious disease, HIV, inflammation, tuberculosis

    Principal Investigator

    Amita Gupta, M.D., M.H.S.

    Department

    Medicine

  • Andrea Cox Lab

    Research in the Andrea Cox Lab explores the immune response in chronic viral infections, with a focus on HIV and the hepatitis C virus (HCV). In our studies, we examine the role of the immune response upon exposure to HCV by examining responses to HCV in a longitudinal, prospective group of high-risk individuals. This enables us to compare the innate, humoral and cellular immune responses to infection with clearance versus persistence. Through our findings, we seek to identify mechanisms of prot...ective immunity against HCV infection and improve HCV vaccine design. view more

    Research Areas: virology, vaccines, viral immunology, HIV, hepatitis C, T cells

    Principal Investigator

    Andrea Cox, M.D., Ph.D.

    Department

    Medicine

  • Anne Rompalo Lab

    Research in the Anne Rompalo Lab focuses on STD research and application. We recently examined the relationship between violence against women and HIV-related risk factors in women living in the United States. Past projects include a nine-year longitudinal observation study of HIV-infected women in Baltimore.

    Research Areas: women, HIV, sexually transmitted diseases, domestic violence

    Principal Investigator

    Anne Rompalo, M.D.

    Department

    Medicine

  • Balagopal Lab - Viral Hepatitis and Translational Virology

    The Balagopal Lab has adapted high-resolution tools to study viruses in situ. Specifically, we were the first to quantify hepatitis C virus (HCV) infection in single hepatocytes by developing single-cell laser capture microdissection (scLCM) and integrating this tool with highly sensitive quantitative real-time PCR. We reported that HCV infects a minority of hepatocytes that are found in geospatial clusters. More recently, we (PIs Balagopal and Thio) integrated scLCM with droplet digital PCR (dd...PCR) to reveal the first observations of hepatitis B virus (HBV) infection at single cell resolution in the liver. We found that HBV infects nearly all hepatocytes prior to antiviral therapy. However, during antiviral therapy, HBV infection is diminished while viral transcription is markedly attenuated.

    Our lab has also focused on HIV-1 infection and immune activation for over a decade. Most recently, we have studied type 1 interferon responses to HIV-1 using RNA sequencing (RNAseq). Using this technology, we identified novel interferon-stimulated genes (ISGs) that are associated with HIV-1 restriction in vivo.
    view more

    Research Areas: HIV-1, hepatitis B, hepatitis C

    Principal Investigator

    Ashwin Balagopal, M.D.

    Department

    Medicine

  • Chloe Thio Lab

    Research in the Chloe Thio lab focuses on several areas. First, HBV virology and immunology in HBV monoinfected and HIV-HBV co-infected individuals that will ultimately help develop a cure for HBV. Second, HCV infection in men who have sex with men. Third, non-alcoholic fatty liver disease with a focus on HIV-infected individuals. Fourth, host genetic determinants of spontaneous HBV recovery and HCV clearance.

    Research Areas: HIV-HBV co-infection, hepatitis B, genomics, hepatitis C, fatty liver

    Principal Investigator

    Chloe Thio, M.D.

    Department

    Medicine

  • Christine Durand Lab

    Dr. Christine Durand, assistant professor of medicine and oncology and member of the Johns Hopkins Kimmel Cancer Center, is involved in clinical and translational research focused on individuals infected with HIV and hepatitis C virus who require cancer and transplant therapies. Her current research efforts include looking at outcomes of hepatitis C treatment after solid organ transplant, the potential use of organs from HIV-infected donors for HIV-infected solid organ transplant candidates, and... HIV cure strategies including bone marrow transplantation.

    Dr. Durand is supported by multiple grants:

    • R01 from the National Institute of Allergy and Infectious Diseases (NIAID) to study HIV-to-HIV organ transplantation in the US.
    • K23 from the National Cancer Institute (NCI) to study antiretroviral therapy during bone marrow transplant in HIV-1 infection.
    • U01 from the NIAID to study HIV-to-HIV deceased donor kidney transplantation.
    U01 from the NIAID to study HIV-to-HIV deceased donor liver transplantation.
    view more

    Research Areas: Bone Marrow Transplantation, transplants, infectious disease, AIDS, HIV, Solid Organ Transplantation, hepatitis C

    Principal Investigator

    Christine Durand, M.D.

    Department

    Medicine

  • Cynthia Sears Laboratory

    Work in the Cynthia Sears Laboratory focuses on the bacterial contributions to the development of human colon cancer and the impact of the microbiome on other cancers and the therapy of cancer. The current work involves mouse and human studies to define how enterotoxigenic Bacteroides fragilis, pks+ Escherichia coli, Fusobacterium nucleatum, biofilms and the colonic microbiota induce chronic colonic inflammation and colon cancer. Prospective human studies of the microbiome and biofilms in screen...ing colonoscopy are in progress as are studies to determine if and how the microbiome impacts the response of individuals with cancer to immunotherapy and other cancer therapies.

    view more

    Research Areas: epidemiology, AIDS, microbiome, colon cancer, enterotoxigenic Bacteroides fragilis, chronic colonic inflammation

    Principal Investigator

    Cynthia Sears, M.D.

    Department

    Medicine
    Oncology

  • David Thomas Lab

    The David Thomas Lab oversees clinical research projects that aim to understand the natural history and pathogenesis of hepatitis C virus infection. A special area of clinical and research focus is liver disease in HIV-infected people.

    Research Areas: HIV, hepatitis C, liver diseases

    Principal Investigator

    David Thomas, M.D., M.P.H.

    Department

    Medicine

  • Eric Nuermberger Lab

    Research in the Eric Nuermberger Lab focuses primarily on experimental chemotherapy for tuberculosis. We use proven murine models of active and latent tuberculosis infection to assess the effectiveness of novel antimicrobials. A key goal is to identify new agents to combine with existing drugs to shorten tuberculosis therapy or enable less frequent drug administration. We're also using a flow-controlled in vitro pharmacodynamic system to better understand the pharmacodynamics of drug efficacy an...d the selection of drug-resistant mutants during exposure to current agents. view more

    Research Areas: pharmacodynamics, chemotherapy, infectious disease, antimicrobials, drugs, antibiotics, Streptococcus pneumoniae, pneumonia, tuberculosis

    Principal Investigator

    Eric Nuermberger, M.D.

    Department

    Medicine

  • Erica Johnson Lab

    Research in the Erica Johnson Lab investigates infection control in military deployment environments as well as infections that are associated with combat trauma. We explore topics such as HIV outcomes, gender-based health issues and disparities in care.

    Research Areas: gender-based health issues, infectious disease, combat trauma, HIV, deployment infection control, health disparities

    Lab Website

    Principal Investigator

    Erica Johnson, M.D.

    Department

    Medicine

  • HIV Quality of Care

    Dr. Stephen Berry’s research focuses on healthcare quality, safety and costs among persons living with HIV, both in the outpatient and inpatient settings. He conducts observational and interventional studies of sexually transmitted infection screening in HIV clinics, with a focus on improving performance to meet national guidelines. He leads observational studies of rates and reasons for hospitalizations and of 30-day readmission rates among HIV patients. He is conducting a randomized study of a... nurse- and pharmacist-based team to reduce inpatient HIV medication errors and increase engagement in outpatient care among persons living with HIV who are hospitalized at The Johns Hopkins Hospital. view more

    Research Areas: health care quality, safety, HIV, sexually transmitted diseases

    Principal Investigator

    Stephen Berry, M.D., Ph.D.

    Department

    Medicine

  • Joel Blankson Lab

    Work in the Joel Blankson Lab explores the mechanism of control of HIV-1 replication in a cohort of patients known as elite controllers or elite suppressors. These patients are HIV-1 seropositive but maintain levels of viremia that are below the limit of detection of standard clinical assays. We feel that elite suppressors represent a potential model for a therapeutic HIV vaccine. Our central hypothesis is that many of these patients are infected with fully replication-competent HIV-1 isolates t...hat are held in check by the immune system. To test this hypothesis, we are studying many different host and viral factors in these patients. view more

    Research Areas: vaccines, infectious disease, HIV, pathogenesis, elite suppressors

    Principal Investigator

    Joel Blankson, M.D., Ph.D.

    Department

    Medicine

  • Jonathan Golub Lab

    Research in the Jonathan Golub Lab focuses primarily on the epidemiology of tuberculosis (TB), specifically in patients infected with HIV. We work with the CDC to explore potential delays in TB diagnoses as well as the risk factors that contribute to death from TB in the United States. Our research also includes ongoing studies of HIV and TB patients in Brazil and South Africa.

    Research Areas: epidemiology, infectious disease, AIDS, HIV, tuberculosis

    Principal Investigator

    Jonathan Golub, Ph.D., M.P.H.

    Department

    Medicine

  • Jonathan Zenilman Lab

    The Jonathan Zenilman lab conducts research related to sexually transmitted diseases (STDs). We are working to develop biological markers for sexual behavior to use in other research. The lab studies sexual risk behaviors in highly vulnerable populations and studies datasets from the Baltimore City Health Department to understand STD trends and behaviors. Additionally, we study nosocomial infections at Johns Hopkins Bayview Medical Center, with a focus on developing an antimicrobial control prog...ram. We also conduct clinical research related to the natural history and microbiology of chronic wounds in the outpatient setting. view more

    Research Areas: behavioral research, biomarkers, sexually transmitted diseases, nosocomial infections

    Principal Investigator

    Jonathan Zenilman, M.D.

    Department

    Medicine

  • Justin Bailey Lab

    Research in the Justin Bailey Lab explores immune responses against hepatitis C virus (HCV), particularly neutralizing antibody responses, with the goal of guiding vaccine development against the virus. Recent studies have demonstrated that early and broad neutralizing antibody (nAb) responses against HCV are associated with HCV clearance, suggesting a key role for nAb in limiting HCV replication. The findings of this research will enhance understanding of how HIV infection may contribute to the... lower rate of HCV clearance in HCV/HIV coinfected individuals, and the results could have implications for persistence of other viruses commonly occurring as coinfections with HIV. view more

    Research Areas: humoral immune response, vaccines, infectious disease, AIDS, HIV, hepatitis C

    Lab Website

    Principal Investigator

    Justin Bailey, M.D., Ph.D.

    Department

    Medicine

  • Karakousis Lab

    The Karakousis Lab is primarily focused on understanding the molecular basis of Mycobacterium tuberculosis persistence and antibiotic tolerance. A systems biology-based approach, including the use of several novel in vitro and animal models, in combination with transcriptional, proteomic, genetic, imaging, and computational techniques, is being used to identify host cytokine networks responsible for immunological control of M. tuberculosis growth, as well as M. tuberculosis regulatory and metabo...lic pathways required for bacillary growth restriction and reactivation. In particular, we are actively investigating the regulatory cascade involved in the mycobacterial stringent response. Another major focus of the lab is the development of host-directed therapies for TB, with the goal of shortening treatment and improving long-term lung function. Additional research interests include the development of novel molecular assays for the rapid diagnosis of latent TB infection and active TB disease, and for the detection of drug resistance. view more

    Research Areas: diagnostics, persistence, infectious disease, Mycobacterium tuberculosis, host-directed therapy, latency, drugs, antibiotics, tuberculosis

    Lab Website

    Principal Investigator

    Petros Karakousis, M.D.

    Department

    Medicine

  • Kathleen Page Lab

    Research in the Kathleen Page Lab examines the impact of bovine colostrum (BC) on immune activation and HIV susceptibility, and aims to develop a point-of-care diagnostic test for histoplasmosis.

    Research Areas: histoplasmosis, infectious disease, HIV, Hispanic Americans

    Principal Investigator

    Kathleen Page, M.D.

    Department

    Medicine

  • Kelly Gebo Lab

    Work in the Kelly Gebo Lab focuses on topics such as evidence-based practice, health utilization, policy generation, health disparities in patient access to health care, HIV/AIDS, aging and hepatitis. As part of the HIV Research Network (HIVRN), our lab gathers clinical and demographic data on HIV-infected patients to help develop a single, nationwide research database. In addition, our ongoing research explores evidence-based practice in relation to the management of hepatitis C as well as HIV/...AIDS in mentally ill patients. We also investigate racial and gender disparities in patients who receive highly active antiretroviral therapy. view more

    Research Areas: Hepatitis, AIDS, HIV, aging, health care policy, evidence-based medicine, health disparities

    Principal Investigator

    Kelly Gebo, M.D., M.P.H.

    Department

    Medicine

  • Lamichhane Lab

    Our research focuses on the biology of the peptidoglycan of Mycobacterium tuberculosis, the organism that causes tuberculosis, and Mycobacteroides abscessus, a related bacterium that causes opportunistic infections. We study basic mechanisms associated with peptidoglycan physiology but with an intent to leverage our findings to develop tools that will be useful in the clinic to treat mycobacterial infections.

    Peptidoglycan is the exoskeleton of bacteria that not only provides structural rigid...ity and cell shape but also several vital physiological functions. Breaching this structure is often lethal to bacteria. We are exploring fundamental mechanisms by which bacteria synthesize and preserve their peptidoglycan. Although our lab uses genetic, biochemical and biophysical approaches to study the peptidoglycan, we pursue questions irrespective of the expertise required to answer those questions. It is through these studies that we identified synergy between two beta-lactam antibiotics against select mycobacteria. view more

    Research Areas: biochemistry, infectious disease, Mycobacterium tuberculosis, genomics, tuberculosis, RNA

    Lab Website

    Principal Investigator

    Gyanu Lamichhane, Ph.D.

    Department

    Medicine

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Molecular Medicine

  • Andrew Feinberg Laboratory

    The Feinberg Laboratory studies the epigenetic basis of normal development and disease, including cancer, aging and neuropsychiatric illness. Early work from our group involved the discovery of altered DNA methylation in cancer as well as common epigenetic (methylation and imprinting) variants in the population that may be responsible for a significant population-attributable risk of cancer.

    Over the last few years, we have pioneered the field of epigenomics (i.e., epigenetics at a genom...e-scale level), founding the first NIH-supported NIH epigenome center in the country and developing many novel tools for molecular and statistical analysis. Current research examines the mechanisms of epigenetic modification, the epigenetic basis of cancer, the invention of new molecular, statistical, and epidemiological tools for genome-scale epigenetics and the epigenetic basis of neuropsychiatric disease, including schizophrenia and autism. view more

    Research Areas: autism, cancer, epigenetics, schizophrenia, human development, aging, DNA, genomics, neuropsychiatric disease

    Lab Website

    Principal Investigator

    Andrew Feinberg, M.D., M.P.H.

    Department

    Medicine

Nephrology

  • C. John Sperati Lab

    Dr. Sperati’s group focuses on complement mediated kidney disorders, glomerular disease, and renal arterial disease secondary to fibromuscular dysplasia. His team has a particular interest in thrombotic microangiopathies involving the complement system.

    Research Areas: kidney diseases, fibromuscular dysplasia, hypertension, hyperaldosteronism, atherosclerosis

    Principal Investigator

    C. John Sperati, M.D., M.H.S.

    Department

    Medicine

  • Deidra Crews Lab

    Dr. Crews’ team focuses on health disparities in chronic kidney disease. We have studied how social determinants of health, such as poverty and healthful food access, affect disparities in kidney disease outcomes. Our research on end-stage renal disease includes studies of the best timing and environment to initiate dialysis among vulnerable populations.

    Research Areas: poverty, chronic kidney disease, health disparities

    Principal Investigator

    Deidra Crews, M.D.

    Department

    Medicine

  • Duvuru Geetha Lab

    Dr. Geetha’s team focuses on renal diseases in patients with systemic vasculitis as well as BK virus nephropathy in patients who have undergone renal transplant. Our studies include clinical trials on the effectiveness of rituximab versus cyclosporine in treating idiopathic membranous nephropathy and a multinational study of belimumab with azathioprine for maintaining remission of granulomatosis with polyangiitis and microscopic polyangiitis. We also have conducted research on the treatment of A...NCA vasculitis, particularly in kidney transplant patients. view more

    Research Areas: granulomatosis with polyangiitis, kidney diseases, vasculitis, kidney transplants, Glomerulonephritis, nephrology

    Principal Investigator

    Duvuru Geetha, M.B.B.S.

    Department

    Medicine

  • Edward Kraus Lab

    Dr. Kraus’ team investigates the factors that impact the long-term success or failure of kidney transplants as well as barriers to nephrology care and transplants in minority populations. We research many topics dealing with kidney transplant rejection, including diagnostic criteria, infection risk and incompatibility factors. Our lab also has a longstanding interest in pancreas transplants and has conducted research to establish guidelines for diagnosing antibody-mediated rejection of pancreas ...allografts-updated Banff grading schema. view more

    Research Areas: kidney transplants, nephrology, health disparities, pancreas transplants

    Principal Investigator

    Edward Kraus, M.D.

    Department

    Medicine

  • Hamid Rabb Lab

    Dr. Rabb’s lab is involved in translational research aimed at understanding the molecular pathogenesis of kidney ischemia/reperfusion injury. The lab is interested in the development of novel treatments for kidney IRI.

    Research Areas: kidney diseases, kidney ischemia/reperfusion injuries, nephrology

    Principal Investigator

    Hamid Rabb, M.D.

    Department

    Medicine

  • Mohamed Atta Lab

    Dr. Atta and his research team explore the epidemiological and clinical interventions of a variety of kidney diseases. Our goal is not only to advance the understanding of many kidney diseases but also to capitalize on novel discoveries of basic science to treat a wide range of rare and common kidney disorders.




    • Multi-international observational study of a rare form of amyloid (LECT2 amyloid) to understand its natural history with the ultimate interest of treating this c...ondition.

    • Our group has launched a project investigating the impact of COVID19 on the kidney to identify risk factors influencing outcome across different clinical phenotypes

    • In collaboration with the Division of Infectious Diseases and the School of Public Health, our research has focused on the epidemiology of HIV and kidney disease. We also study clinical markers and contributing factors in the progression of kidney disease, and the association between kidney disease and heart disease.

    • Our research group is participating in a multicenter consortium serving as a clinical core site to study the pathogenesis of HIV-associated kidney disease by providing well-characterized clinical specimens and corresponding clinical and laboratory data.

    view more

    Research Areas: kidney diseases, HIV, hepatitis C

    Principal Investigator

    Mohamed Atta, M.B.B.Ch., M.D., M.P.H.

    Department

    Medicine

  • Nada Alachkar Lab

    Dr. Alachkar's research focuses on recurrent glomerular diseases post kidney transplantation. In particular, she has been studying recurrent FSGS post kidney transplant in several, partially NIH funded, prospective research projects that focuses on circulating factors associate with recurrent FSGS and new therapies of recurrent FSGS; in addition to the outcome of the disease. Also, Dr. Alachkar is the Chair of Banff recurrent GN working group that focus on the pathological changes of recurrent G...N.


    Dr. Alachkar's other research focus is incompatible living and diseases donor transplant. She has several ongoing research studies that focus on AMR and the outcome of patients with positive donor specific antibodies.
    view more

    Research Areas: Focal segmental glomerular sclerosis in the transplanted kidney, Recurrent glomerular diseases post kidney transplant, Incompatible kidney transplant

    Principal Investigator

    Nada Alachkar, M.D.

    Department

    Medicine

  • Stephen Sozio Lab

    Dr. Sozio’s research focuses on 1) Clinical research related to chronic kidney disease and end stage renal disease, and 2) Educational research in undergraduate and graduate medical education.



    The Sozio lab pursues work related to stroke, cognitive impairment, manifestations of kidney disease, and systematic reviews on clinical topics, and collaborates on multiple projects with other key investigators. In particular, Dr. Sozio has been an active investigator in the Choices for Hea...lthy Outcomes in Caring for ESRD (CHOICE) Study, Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease (PACE) Study, Chronic Renal Insufficiency Cohort (CRIC) Study, and work funded through the Agency for Healthcare Research and Quality (AHRQ) and Johns Hopkins Evidence-Based Practice Center. In addition, the Sozio lab performs studies at the UME and GME levels, investing in understanding learners’ mentorship, research, and transitional experiences. view more

    Research Areas: end stage renal disease (ESRD), epidemiology, kidney diseases, stroke

    Principal Investigator

    Stephen Sozio, M.D.

    Department

    Medicine

Occupational Medicine

  • Grant (Xuguang) Tao Lab

    Research in the Grant (Xuguang) Tao Lab explores environmental and occupational epidemiology topics, including workers' compensation and injuries, and nosocomial infections. We conduct research through clinical trials and systematic literature reviews, and also use cancer registry data and GIS applications in environmental epidemiological research. Our recent studies have explored topics such as the effectiveness of lumbar epidural steroid injections following lumbar surgery, the effect of physi...cian-dispensed medication on workers' compensation claim outcomes and how the use of opioid and psychotropic medications for workers' compensation claims impacts lost work time. view more

    Research Areas: epidemiology, drug safety, cancer, nosocomial infections, GIS applications

    Principal Investigator

    Grant Tao, M.D., Ph.D., M.S.

    Department

    Medicine

Pulmonary and Critical Care Medicine

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  • Alison E. Turnbull Lab

    Research in the Alison E. Turnbull Lab focuses on patient-clinician interactions. We study decision-making processes for ICU patients and their families and focus on the long-term outcomes of ICU survivors. Additional research examines ways to improve end-of-life care for patients.

    Research Areas: epidemiology, palliative care, medical decision making, ICU

  • Brian Garibaldi Lab

    Research in the Brian Garibaldi Lab focuses on acute lung injury (ALI) resolution. Recently, we evaluated the mechanisms underlying mobility therapy and found that therapeutic exercise reduces neutrophilic lung injury and skeletal muscle wasting in ALI mice.

    Research Areas: pulmonary medicine, acute lung injury

    Principal Investigator

    Brian Garibaldi, M.D.

    Department

    Medicine

  • Charles Wiener Lab

    The Charles Wiener Lab primarily conducts research on pulmonary circulation and hypoxia as well as respiratory muscle function in patients with neuromuscular diseases. Our recent studies have included investigating the treatment of pericardial effusions in patients with pulmonary arterial hypertension and examining the use of non-invasive ventilation in patients with amyotrophic lateral sclerosis (ALS). We also have an interest in medical education research. Our work in this area has included re...viewing the role of academic medical centers in emerging health care markets. view more

    Research Areas: respiratory system, neuromuscular diseases, ALS, pulmonary medicine, hypertension, hypoxia

    Principal Investigator

    Charles Wiener, M.D.

    Department

    Medicine

  • Christian Merlo Lab

    Work in the Christian Merlo Lab includes studies on pulmonary arteriovenous malformations, outcomes in lung transplantation and treatment of cystic fibrosis (CF), and HIV-related pulmonary disease. We have studied methods of diagnosing and managing pulmonary arteriovenous malformations as well as the outcomes of adult CF patients who are infected with multiple antibiotic-resistant Pseudomonas aeruginosa. Our recent research has also explored recipient and donor variables in the success or failur...e of lung transplants, and ways in which national healthcare delivery systems impact lung transplant outcomes for CF patients. view more

    Research Areas: cystic fibrosis, pulmonary arteriovenous malformations, HIV, lung disease, lung transplant

    Principal Investigator

    Christian Merlo, M.D., M.P.H.

    Department

    Medicine

  • David Hager Lab

    Research in the David Hager Lab focuses on critical care medicine. Recent studies includes an analysis of advances in the management of the acute respiratory distress syndrome (ARDS) and the development of a targeted real-time early warning score predicting septic shock. Other interests include ventilator-induced lung injury and high-frequency ventilation.

    Research Areas: critical care medicine, acute respiratory distress syndrome, high-frequency ventilation, ventilator-induced lung injury

    Principal Investigator

    David Hager, M.D., Ph.D.

    Department

    Medicine

  • Edward Chen Lab

    Research efforts in the Edward Chen Lab focus on bleomycin-induced pulmonary fibrosis and granulomatous inflammation as well as clinical and translational studies in sarcoidosis. Our studies have included topics such as the etiologies of sarcoidosis, hylleraas hydride binding energy in diatomic electron affinities, and molecular convergence of neurodevelopmental disorders. We have also investigated the use of quantitative mass spectrometric analysis to better understand the mechanisms of phospho...-priming and auto-activation of the checkpoint kinase Rad53 in vivo. view more

    Research Areas: pulmonary medicine, sarcoidosis, granulomatous inflammation, pulmonary fibrosis

    Principal Investigator

    Edward Chen, M.D.

    Department

    Medicine

  • Elizabeth Daugherty Lab

    The Elizabeth Daugherty Lab conducts research on patient safety, critical care infection control and critical care disaster response. We investigate methods of improving patient safety through improved infection control, with a focus on clinical outcomes, nosocomial infection rates and the individual and organizational obstacles to personal protective equipment adherence.

    Research Areas: critical care medicine, patient safety, infection control, nosocomial infections

    Principal Investigator

    Elizabeth Daugherty, M.D., M.P.H.

    Department

    Medicine

  • Elizabeth Wagner Lab

    The Elizabeth Wagner Lab conducts research on several topics within the field of pulmonary medicine. Our key areas of investigation include angiogenesis of the lung and its dependence upon systemic vascularization to regions without pulmonary perfusion as well as the role of bronchial circulation in the uptake of hydrophilic particles that are delivered to the airway surface. In addition, we are conducting several specific studies that examine the relationship between the bronchial vasculature a...nd the influx of inflammatory cells to a patientÕs airways. view more

    Research Areas: lung ischemia, pulmonary medicine, vascular remodeling, vascular biology, angiogenesis

    Principal Investigator

    Elizabeth Wagner

    Department

    Medicine

  • Franco D’Alessio Lab

    The Franco D’Alessio Lab investigates key topics within the fields of critical care, internal and pulmonary medicine. We primarily explore immunological determinants of acute lung inflammation and repair. Our lab also investigates age-dependent lung immune response in patients with acute lung injury and acute respiratory distress syndrome (ARDS), regulatory T-cells in lung injury and repair, and modulation of alveolar macrophage innate immune response in ARDS.

    Research Areas: critical care medicine, acute respiratory distress syndrome, acute lung injury, lung inflammation, lung disease, T cells

    Principal Investigator

    Franco D'Alessio, M.D.

    Department

    Medicine

  • Gregory Diette Laboratory

    The Gregory Diette Laboratory studies the epidemiology of lung diseases. Our focus is on asthma, chronic obstructive pulmonary disease (COPD) and environmental causes of lung disease, including allergens and particulate matter.

    Research Areas: epidemiology, asthma, allergies, lung disease, COPD

    Principal Investigator

    Gregory Diette, M.D.

    Department

    Medicine

  • Henry Fessler Lab

    Research in the Henry Fessler Lab is focused on pulmonary medicine. We are interested in heart-lung interaction, mechanical ventilation and lung mechanics. We’re also interested in medical education and recently examined contemporary strategies for effective lecturing.

    Research Areas: medical education, heart-lung interaction, pulmonary medicine

    Principal Investigator

    Henry Fessler, M.D.

    Department

    Medicine

  • James Sham Lab

    Research in the James Sham Lab focuses on pulmonary arteries. Studies include local calcium signaling in the pulmonary arteries and transient receptor potential (TRP) channels in pulmonary arterial smooth muscle cells. We’re also interested in calcium regulation in chronic hypoxic pulmonary hypertension.

    Research Areas: chronic hypoxic pulmonary hypertension, pulmonary medicine, arteries

    Principal Investigator

    James Sham, Ph.D.

    Department

    Medicine

  • Jonathan Jun Lab

    The Jonathan Jun Lab studies the function of lipolysis in intermittent hypoxia-induced insulin resistance.

    Research Areas: critical care medicine, lipolysis, pulmonary medicine, intermittent hypoxia-induced insulin resistance

    Lab Website

    Principal Investigator

    Jonathan Jun, M.D.

    Department

    Medicine

  • Kristin Riekert Lab

    Work in the Kristin Riekert Lab focuses on methods for improving health care quality and delivery, particularly among underserved and disadvantaged populations. Our research covers a range of important topics, including health beliefs, treatment adherence, doctor-patient communication, self-management interventions, mobile health initiatives, health disparities and patient-reported outcome methodology. We also work with the National Institutes of Health on multiple intervention trials focused on... improving adherence and health outcomes in asthma, chronic kidney disease, cystic fibrosis (CF), sickle cell disease and secondhand smoke reduction. view more

    Research Areas: health care quality, treatment adherence, cystic fibrosis, patient-provider relationships, chronic illnesses, health disparities

    Principal Investigator

    Kristin Riekert, Ph.D.

    Department

    Medicine

  • Landon King Lab

    The Landon King Lab studies aquaporins water-specific membrane channel proteins. We hope to understand how these proteins contribute to water homeostasis in the respiratory tract and how their expression or function may be altered in disease states.

    Research Areas: respiratory system, proteomics, aquaporins

    Principal Investigator

    Landon King, M.D.

    Department

    Medicine

  • Larissa Shimoda Lab

    Research in the Larissa Shimoda Lab focuses on several important topics within pulmonary and critical care medicine. We primarily study pulmonary arterial responses to chronic hypoxia as well as hypoxic pulmonary vasoconstriction and oxidant-mediated lung injury. Our recent research has included investigating the effects of chronic hypoxia on pulmonary circulation and the ways in which hypoxia-inducible factors impact pulmonary vascular responses to hypoxia. We have also studied vascular remodel...ing in patients with pulmonary hypertension. view more

    Research Areas: critical care medicine, lung injury, pulmonary medicine, lung disease, hypoxia

    Principal Investigator

    Larissa Shimoda, Ph.D., M.S.

    Department

    Medicine

  • Lonny Yarmus Lab

    Clinical trials conducted in the Lonny Yarmus Lab focus primarily on minimally-invasive diagnostic testing for patients with lung cancer and local therapy options for malignant airway obstructions. We investigate ways to improve the early diagnosis of lung cancer, as well as the treatment of later-stage cancer, using the least invasive methods possible. We are also part of the LIBERATE clinical study for patients who have difficulty breathing and suffer from severe emphysema.

    Research Areas: emphysema, interventional pulmonology, airway stenosis, minimally-invasive diagnostic testing, lung cancer, central airway obstructions, lung transplant

    Principal Investigator

    Lonny Yarmus, D.O.

    Department

    Medicine

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Rheumatology

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  • Alan Baer Lab

    Research in the Alan Baer Lab focuses on Sjogren's syndrome. Previously, we conducted the Sjogren's International Registry (SICCA), enrolling 300 patients and creating a valuable source of clinical data and biospecimens for research we're conducting with colleagues at Johns Hopkins and the University of California-San Francisco. Currently, we're conducting a longitudinal observational study of patients with Sjogren's syndrome. We're also collaborating with Dr. Ben Larman in the Department of Pathology, using phage immuno-precipation sequencing to work on a characterization of the complete autoantibody repertoire in Sjogren's syndrome patients.

    Research Areas: autoantibodies, Sjogren's syndrome, autoimmune rheumatic diseases, observational data

    Principal Investigator

    Alan Baer, M.D.

    Department

    Medicine

  • Allan Gelber Lab

    The Allan Gelber Lab conducts research on the clinical epidemiology of rheumatic disorders. Our recent studies have explored topics that include the predicting factors of prevalent and incident gout; cardiovascular disease burden and risk in patients with rheumatoid arthritis; autoantibodies in both primary and secondary SjogrenÕs syndrome; and predictors of outcomes in patients with scleroderma. In addition, we have a long-standing interest in the ways in which racial differences affect disease manifestations in relation to rheumatic disorders.

    Research Areas: rheumatology, gout, Sjogren's syndrome, scleroderma, race, health disparities, rheumatoid arthritis

    Principal Investigator

    Allan Gelber, M.D., Ph.D., M.P.H.

    Department

    Medicine

  • Ami Shah Lab

    Researchers in the Ami Shah Lab study scleroderma and Raynaud’s phenomenon. We examine the relationship between cancer and scleroderma, with a focus on how and if cancer causes scleroderma to develop in some patients. We are currently conducting clinical research to study ways to detect cardiopulmonary complications in patients with scleroderma, biological and imaging markers of Raynaud’s phenomenon, and drugs that improve aspects of scleroderma.

    Research Areas: Raynaud's phenomenon, cancer, scleroderma, drugs, cardiovascular diseases

    Lab Website

    Principal Investigator

    Ami Shah, M.D.

    Department

    Medicine

  • Ana-Marie Orbai Lab

    The Ana-Marie Orbai Lab focuses on inflammatory arthritis. Current clinical research projects in the lab examine patient symptoms and experiences in rheumatic diseases and inflammatory arthritis. We focus on stiffness in rheumatoid arthritis and patient-reported outcomes. Previous research in the lab focused on systemic lupus erythemaous (SLE).

    Research Areas: autoimmune rheumatic diseases, arthritis, rheumatoid arthritis

    Lab Website

    Principal Investigator

    Ana-Maria Orbai, M.D., M.H.S.

    Department

    Medicine

  • Antony Rosen Lab

    Research in the Antony Rosen Lab investigates the mechanisms shared by the autoimmune rheumatic diseases such as lupus, myositis, rheumatoid arthritis, scleroderma and SjogrenÕs syndrome. We focus on the fate of autoantigens in target cells during various circumstances, such as viral infection, relevant immune effector pathways and exposure to ultraviolet radiation. Our recent research has sought to define the traits of autoantibodies that enable them to induce cellular or molecular dysfunction. We also work to better understand the mechanisms that form the striking connections between autoimmunity and cancer.

    Research Areas: myositis, lupus, rheumatology, Sjogren's syndrome, scleroderma, autoimmune rheumatic diseases, rheumatoid arthritis

    Principal Investigator

    Antony Rosen, M.B.Ch.B., M.S.

    Department

    Medicine

  • Clifton O. Bingham III Lab

    Research in the Clifton O. Bingham III Lab focuses on defining clinical and biochemical disease phenotypes related to therapeutic responses in rheumatoid arthritis and osteoarthritis; developing rational clinical trial designs to test new treatments; improving patient-reported outcome measures; evaluating novel imaging modalities for arthritis; and examining the role of oral health in inflammatory arthritis.

    Research Areas: biochemistry, imaging, osteoarthritis, clinical trials, inflammation, oral health, rheumatoid arthritis

    Principal Investigator

    Clifton O. Bingham, M.D.

    Department

    Medicine

  • Erika Darrah Lab

    The Erika Darrah Lab is primarily interested in the mechanisms underlying the development and progression of autoimmunity in rheumatoid arthritis (RA), with a particular focus on the peptidyl arginine deiminase (PAD) enzymes. We’re focused on understanding the development of PAD4-activating autoantibodies over time and how they contribute to the development of erosive disease. Studies are underway to determine if the newly discovered antibody is mimicking a naturally occurring PAD4 binding partner and to identify potentially pro-inflammatory effects of citrullinated proteins on effector cells of the immune system.

    Research Areas: antibodies, autoimmune diseases, peptidylarginine deiminase enzymes, rheumatoid arthritis

    Lab Website

    Principal Investigator

    Erika Darrah, Ph.D.

    Department

    Medicine

  • Felipe Andrade Laboratory

    Research in the laboratory of Felipe Andrade, M.D., Ph.D., focuses on the mechanisms of systemic autoimmune diseases, particularly as they relate to the role of cytotoxic granule proteases in autoimmunity and viral clearance, mechanisms of autoantigen citrullination and pathways that control immune effector functions in autoimmune diseases. We currently focus on two principal areas: (1) defining the mechanisms that generate citrullinated autoantigens in vivo in rheumatoid arthritis and (2) understanding the pathways that control the activity of the peptidylarginine deiminase (PAD) enzymes in human neutrophils.

    Research Areas: autoantigens, autoimmune diseases, cytotoxic granule proteases, peptidylarginine deiminase enzymes, rheumatoid arthritis

    Principal Investigator

    Felipe Andrade, M.D., Ph.D.

    Department

    Medicine

  • Fredrick Wigley Lab

    The Frederick Wigley Lab is interested in the signs, symptoms and causes of scleroderma. We are testing new treatments for RaynaudÕs phenomenon and scleroderma. Understanding the treatment approach to Raynaud's phenomenon and associated ischemia and how to prevent digital ulcers is important for clinicians caring for these patients. Work in our lab has provided guidance in the management of Raynaud's phenomenon and digital ischemic ulcers, including options for the practical pharmacologic and nonpharmacologic interventions.

    Research Areas: Raynaud's phenomenon, rheumatology, scleroderma, autoimmune diseases, systemic sclerosis, ischemic ulcers

    Principal Investigator

    Fredrick Wigley, M.D.

    Department

    Medicine

  • John Aucott Lab

    Research in the John Aucott Lab focuses on the development of accurate diagnostic tests for all stages of Lyme disease. We work closely with Dr. Mark Soloski on the Study of Lyme disease Immunology and Clinical Events (SLICE), a longitudinal, matched-control study of patients diagnosed with early untreated Lyme disease. The objective is to use the collected biological samples to help identify novel Lyme disease biomarkers that can inform diagnoses, outcomes and the knowledge about disease pathophysiology.

    Research Areas: clinical outcomes, gender differences, biomarkers, pathophysiology, immune heterogeneity, Lyme disease

    Principal Investigator

    John Aucott, M.D.

    Department

    Medicine

  • Laura Hummers Lab

    The Laura Hummers Lab participates in a number of clinical trials and clinical investigations at the Scleroderma Center at Johns Hopkins. We have a particular interest in the predictors of outcomes in scleroderma. We’ve established a prospective cohort of 300 scleroderma patients to identify incident vascular outcomes in the hopes of identifying new biomarkers for disease development and progression.

    Research Areas: rheumatology, biomarkers, scleroderma

    Lab Website

    Principal Investigator

    Laura Hummers, M.D.

    Department

    Medicine

  • Livia Casciola-Rosen Lab

    Work in the Livia Casciola-Rosen Lab explores the shared mechanisms present in autoimmune rheumatic diseases, specifically scleroderma, Sjogren's syndrome and myositis. We use disease-specific autoantibodies to identify the factors that cause the autoimmune response in such diseases. Our current research involves identifying the antigen targets of autoimmune diseases, investigating the autoantigens targeted in cancers associated with rheumatic diseases and finding unique clinical biomarkers, such as the anti-HMGCR antibody specificity.

    Research Areas: autoantibodies, myositis, rheumatology, Sjogren's syndrome, scleroderma, autoimmune rheumatic diseases

    Principal Investigator

    Livia Casciola-Rosen, Ph.D.

    Department

    Medicine

  • Paul Rothman Lab

    Research in the Paul Rothman Lab has focused on cytokines. We’ve investigated the role these molecules play in the normal development of blood cells as well as the abnormal blood-cell development that leads to leukemia. We’ve also studied the function of cytokines in immune system responses to asthma and allergies.

    Research Areas: leukemia, asthma, allergies, cytokines, immune system

    Lab Website

    Principal Investigator

    Paul Rothman, M.D.

    Department

    Medicine

  • Philip Seo Lab

    Research interests in the Philip Seo Lab include the assessment and treatment of ANCA-associated vasculitides, particularly Churg-Strauss syndrome, granulomatosis with polyangiitis and microscopic polyangiitis.

    Research Areas: microscopic polyangiitis, granulomatosis with polyangiitis, Churg-Strauss syndrome, autoimmune diseases

    Principal Investigator

    Philip Seo, M.D.

    Department

    Medicine

  • Thomas Grader-Beck Lab

    Research in the Thomas Grader-Beck Lab aims to understand the pathogenesis of systemic autoimmune diseases—particularly systemic lupus erythematosus (SLE) and Sjögren’s syndrome—by taking a translational approach. Autoantibodies (antibodies that target self-molecules) are believed to contribute significantly to the disease process. We are studying mechanisms that may make self-structures immunogenic. We theorize that certain post-translational antigen modifications, which can occur in infections or malignant transformation, result in the expression of neoepitopes that spread autoimmunity in the proper setting. The team has combined studies that employ a number of mouse strains, certain gene-deficient mice and human biological specimens.

    Research Areas: Sjogren's syndrome, antibodies, autoimmune diseases, self-molecules, systemic lupus erythematosus

    Principal Investigator

    Thomas Grader-Beck, M.D., Ph.D.

    Department

    Medicine

  • Zsuzsanna McMahan Lab

    The Zsuzsanna McMahan Lab conducts translational research that seeks to identify the novel antigens in scleroderma and to define the target tissue in this disease. We are conducting two active clinical research trials, including one that studies skin biopsy specimens as biomarkers of scleroderma and the response to mycophenolate mofetil (MMF or Cellcept). The other study is a gastrointestinal involvement registry that follows patients who are experiencing GERD, small bowel bacterial overgrowth, constipation, fecal incontinence and gastroparesis to see if there is improvement in symptoms after a change in treatment is implemented.

    Research Areas: gastrointestinal system, rheumatology, biomarkers, scleroderma, antigens, mycophenolate mofetil

    Lab Website

    Principal Investigator

    Zsuzsanna McMahan, M.D., M.H.S.

    Department

    Medicine

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