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Title:
Pilot Study of MLN0128 in Preoperative Recurrent Glioblastoma (GBM) Patients
Protocol Number:
N1301
Phase:
Pilot
Physician:
Stuart Grossman
Sites:
Johns Hopkins Kimmel Cancer Center in Baltimore
Purpose:
The primary objective of the pilot study is to evaluate the penetration of MLN0128 across the blood brain barrier and achieve a concentration of 70 nM in tissue resected from a contrast enhancing region of the tumor in 60% of recurrent GBM patients. In addition secondary objective is to determine the ability of MLN0128 to inhibit TORC1/2 in the enhancing components of the tumor as determined by modulation of RPS6 pS235 in reverse phase protein array (RPPA) assays.
Eligibility:
Treatment:
Population:
Adult
Last Update
03/05/2019 05:03 AM