A Phase 1 Study of AZD8186 in Combination with Docetaxel in patients with PTEN mutated or PIK3CB mutated advanced solid tumors, potentially amenable to docetaxel (ETCTN10131)
Johns Hopkins Kimmel Cancer Center in Baltimore
PRIMARY OBJECTIVES:I. To determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of PI3Kbeta inhibitor AZD8186 (AZD8186) when administered in combination with docetaxel in patients with PTEN or PIK3CB mutated advanced solid tumors.II. To assess the safety and tolerability of AZD8186 when administered in combination with docetaxel in patients with PTEN or PIK3CB mutated advanced solid tumors.SECONDARY OBJECTIVES:I. To observe and record anti-tumor activity. II. To assess the objective response rate (ORR) of AZD8186 when administered in combination with docetaxel in patients with PTEN or PIK3CB mutated advanced solid tumors.III. To assess the clinical benefit rate at 24 weeks of AZD8186 when administered in combination with docetaxel in patients with PTEN or PIK3CB mutated advanced solid tumors.IV. To investigate a drug-drug interaction between docetaxel and AZD8186 and correlate drug exposure with pharmacodynamics response.TERTIARY OBJECTIVES:I. Examine the pattern of co-mutated genes in PTEN or PIK3CB mutated tumors and their association with treatment response or resistance.II. Describe possible mechanisms of acquired resistance to PI3Kbeta inhibition.III. Evaluation of protein expression of the PTEN gene and its association with treatment response or resistance.IV. Examine isoform-specific AKT inhibition and other downstream target modulation from PI3Kbeta inhibition with AZD8186.
Inclusion Criteria:•Patients must have histologically confirmed malignancy that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective•Patients must be able to swallow and retain oral medications and be without gastrointestinal illnesses that would preclude absorption of AZD8186•Unlimited prior therapies allowed•Docetaxel appropriate?Patients who have not received prior docetaxel (or other taxane therapy) in the advanced setting are eligible for all cohorts?Patients who have previously received docetaxel (or other taxane therapy) in the advanced setting are eligible for the dose escalation cohort only, if anticipated to have maintained taxane sensitivity and in the opinion of the investigator would still benefit from further docetaxel therapy•Eastern Cooperative Oncology Group (ECOG) performance status equal to less than 2 (Karnofsky greater than equal to 60%)•Leukocytes greater than equal to 3,000/mcL•Absolute neutrophil count greater than equal to 1,500/mcL•Platelets greater than equal to 100,000/mcL•Total bilirubin within normal institutional limits (patients with confirmed Gilbert's syndrome with a total bilirubin equal to less than 2.0 x upper limit of normal [ULN], may be included in this study)•Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) equal to less than 1.5 x institutional upper limit of normal•Creatinine within normal institutional limits OR creatinine clearance greater than equal to 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal•PTEN or PIK3CB mutated advanced solid tumor?PTEN loss of function mutation or PIK3CB gain of function mutation identified by local Clinical Laboratory Improvement Act (CLIA) certified next generation sequencing (NGS)?Breast cancers patients enrolled on this study must have either:?Estrogen receptor positive and HER2 negative breast cancer?Triple negative breast cancer•Adequate archival tissue (metastatic tissue sample is preferable but primary tumor tissue will be acceptable) or willing to undergo pre-treatment biopsy (for central confirmation of molecular alteration and PTEN immunohistochemical assessment) if adequate archival tissue is unavailable•Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; men treated or enrolled on this protocol must also agree to use adequate contraception prior to the study, for the duration of study participation, and 4 months after completion of AZD8186 administration•Ability to understand and the willingness to sign a written informed consent document•DOSE ESCALATION COHORT: Prior receipt of docetaxel is permitted•DOSE ESCALATION COHORT: Measurable disease is not required for enrollment•PHARMACODYNAMIC EXPANSION COHORT: Prior receipt of docetaxel is not permitted•PHARMACODYNAMIC EXPANSION COHORT: Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as greater than equal to 20 mm ( greater than equal to 2 cm) by chest x-ray or as greater than equal to 10 mm ( greater than equal to 1 cm) with computed tomography (CT) scan, magnetic resonance imaging (MRI), or calipers by clinical exam•PHARMACODYNAMIC EXPANSION COHORT: Consent to allow mandatory paired (pre- and on- treatment) fresh tissue biopsies if deemed safe to do so for quantitation of Akt pathway signaling proteins•DISEASE SPECIFIC EXPANSION COHORTS: Prior receipt of docetaxel is not permitted•DISEASE SPECIFIC EXPANSION COHORTS: Patients (excepting the prostate cancer patients) must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as greater than equal to 20 mm ( greater than equal to 2 cm) by chest x-ray or as greater than equal to 10 mm ( greater than equal to 1 cm) with CT scan, MRI, or calipers by clinical exam•DISEASE SPECIFIC EXPANSION COHORTS: Breast cancers patients enrolled on this study must have:?Metastatic or advanced (incurable and unresectable) HER2 negative breast cancer regardless of estrogen receptor status (both hormone receptor positive and triple negative patients are eligible)?Received hormonal therapy, as appropriate based on their hormone receptor status; hormone receptor positive patients who have not received endocrine therapy for recurrent/metastatic disease are eligible, permitted their physician feels they are not appropriate for first line endocrine therapy, for example for high risk visceral metastatic disease•DISEASE SPECIFIC EXPANSION COHORTS: Prostate cancers patients enrolled on this study must have:?Metastatic or advanced (incurable and unresectable) castration resistant metastatic cancer?Received at least one additional line of anti-androgen therapy with abiraterone or enzalutamide?Measurable disease is not required for enrollmentExclusion Criteria:•HER2 positive breast cancer•Prior treatment with PI3K/AKT inhibitors•Any known concurrent RAF or PIK3CA mutation•Patients who have had chemotherapy, radiotherapy, immunotherapy or anticancer agents within 4 weeks (6 weeks for nitrosoureas or mitomycin C) of the first dose of study treatment, except hormonal therapy with luteinizing hormone-releasing hormone (LHRH) analogues for medical castration in patients with prostate cancer and breast cancer, which are permitted•Patients who have not recovered from adverse events due to prior anti-cancer therapy (i.e., have residual toxicities greater than grade 1)•Patients who are receiving any other investigational agents•Patients with known brain metastases should be excluded from this clinical trial•History of clinically significant allergic reactions attributed to compounds of similar chemical or biologic composition to AZD8186 or docetaxel or to docetaxel itself•Patients receiving any medications or substances that are strong inhibitors and/or strong or moderate inducers of CYP3A4 are ineligible•Existing bleeding or condition associated with increased risk of bleeding•Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, uncontrolled hypertension, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements•Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with AZD8186; these potential risks may also apply to other agents used in this study•Human immunodeficiency virus (HIV)-patients positive for human immunodeficiency virus (HIV) are NOT excluded from this study, but HIV-positive patients must have:?A stable regimen of highly active anti-retroviral therapy (HAART) that does not include strong inhibitors and strong or moderate inducers of CYP3A4?No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections?A CD4 count above 250 cells/mcL and an undetectable HIV viral load on standard polymerase chain reaction (PCR)-based test
This is a dose-escalation study of PI3Kbeta inhibitor AZD8186.Patients receive docetaxel intravenously (IV) over 1 hour on day 1 and PI3Kbeta inhibitor AZD8186 orally (PO) twice daily (BID) for 5 days each week. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.After completion of study treatment, patients are followed up for 30 days and then every 3 months.
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