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The Sidney Kimmel Comprehensive Cancer Center

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BRAF Brain Tumor Center

The Johns Hopkins Kimmel Cancer Center has an outstanding Brain Cancer Program which is now committed to:
  1. Evaluate and treat patients with BRAF mutated primary brain tumors
  2. Explore the role of new pathway inhibitors that might work in this patient population
  3. Partner with our basic science colleagues to discover mechanisms of resistance, clinically relevant targets, and new pathway-specific drugs.

BRAF Brain Tumor Center Directors

Karisa Schreck, MD, PhD

Our specialists from Adult and Pediatric Neuro-Oncology, Radiation Oncology, Neurosurgery, Radiology, Pharmacy, and Nursing within Johns Hopkins Medicine are working together to ensure the best possible outcome for this special patient population.

About BRAF

  • BRAF is a gene that can be abnormally activated in cancers. It encodes a protein that sends signals inside the cell promoting tumor growth.
  • Drugs that inhibit this pathway have had genuine success in other cancers with BRAF mutations (such as melanoma – a type of skin cancer).
  • BRAF mutated brain tumors are uncommon.  However, as genetic testing is being conducted more frequently, more patients with this specific mutation are being found.
  • Unfortunately, the drugs used in other BRAF mutated cancers are not currently “approved” for patients with BRAF mutated brain tumors.  These drugs are expensive and are often difficult for patients to obtain.  Furthermore, it is not clear which of these drugs best penetrate the blood-brain barrier or are the most effective in brain cancers. 

Make an Appointment

To schedule an appointment, please contact Tiffany Foster by phone at 410-614-8906 or by e-mail at