The field of epigenetics, characterized by chemical alterations to genes that support the growth and spread of cancer without mutating the DNA, becomes part of mainstream cancer medicine. The Cancer Center’s discoveries in genetics and epigenetics were regarded as the most relevant in cancer biology, earning the Center the nickname “Cancer Research Powerhouse.” 

The National Cancer Act of 1971 leads to the creation of the National Cancer Institute. In 1973, the trustees of the University and Hospital approved the construction of the Johns Hopkins Oncology Center, which opened in April 1977. The Center was among the first to earn comprehensive cancer center status and recognition as a “Center of Excellence.”