In This Section      

Anxiety, Depression and Other Mood Disorders

1. Are You Over 60 and Feeling Depressed?

Are you over 60 and feeling depressed? Symptoms of depression in older adults are common yet often go undetected. They could include feelings of sadness or hopelessness, loss of energy, inability to enjoy pleasurable activities, changes in appetite or sleeping patterns, or poor concentration/memory.

If you are feeling depressed, not taking antidepressant medication and in good physical health you may be eligible to participate in a research study involving treatment. Qualified people will participate at no cost to them and will be compensated for their time and transportation.

For more information about the research study, please call 410-550-4192.

PI: Gwenn Smith, Ph.D.

2. Child Gaining Weight on Medication?

Mark Riddle, M.D., and colleagues in the Johns Hopkins Division of Child and Adolescent Psychiatry are conducting a treatment research study funded by the National Institute of Mental Health. The goal of the study is to find improved treatments for youth who have a have gained weight while taking antipsychotic medication.

We are currently seeking children ages 8-19 who are taking olanzapine (Zyprexa®), quetiapine (Seroquel®), risperidone (Risperdal®), aripiprazole (Abilify®), or ziprasidone (Geodone®) and have gained a significant amount of weight in the past year while taking one of these medications. Consenting children who meet eligibility criteria will receive a medical and psychiatric evaluation and will be assigned to one of three groups: 1) stay on current medication, 2) switch from current medication to aripiprazole (Abilify®) or perphenazine (Trilafon®), 3) stay on current medication and add metformin (Glucophage®). Participants receive study-related evaluations and treatment at no cost.

For further information, call 410-614-5174.

PI: Mark Riddle, M.D.

3. Childhood Depression and Anxiety

Childhood depression and anxiety greatly impact the lives of sufferers, taking away their ability to enjoy their childhood and making them a ghost or shadow of their former selves. We want to change this. We’re conducting ADVANCE – a clinical research study looking at how an investigational treatment called Lu AA21004 is processed in the body over time in children aged 7 to 17 years (inclusively) with depression or anxiety. Study-related treatments and procedures will be provided at no cost to you.

To find out more or to see if your child qualifies, please contact the study coordinator at 443-923-3850.

PI: Robert L. Findling, M.D., MBA

4. Sprites: Sertraline Pediatric Registry for the Evaluation of Safety

Kennedy Krieger Institute is looking for children, ages 6 through 14 years (inclusive), who have been prescribed sertraline within the last 30 days, or have initiated psychosocial rather than pharmacological treatment within the last 30 days.

This research study is being conducted by centers across the country to add meaningful information on the safety of long-term sertraline use in pediatric subjects. The research study involves visits which will consist of cognition, emotional and physical development, and pubertal maturation assessments. There are no direct medical benefits for participating in this research study. The research study will require a screening visit that could last up to two hours, as well as visits at 12 weeks, six months and every six months thereafter for three years (each lasting approximately 30 minutes). For each completed visit, you will be reimbursed up to $25 for your expenses related to your child’s participation to cover your parking, gas and time, OR your child will receive a $10 iTunes® card (or equivalent) to compensate them for their time.

For more information about this study, please contact the study coordinator at 443-923-7619.

PI: Robert L. Findling, M.D., MBA

5. Is Your Teen Too Often Angry or Irritable?

We are conducting a research study at Johns Hopkins that evaluates the effectiveness of a specific psychotherapy for adolescents, between the ages of 12 and 17, who have chronic anger and irritability, disproportionate emotional reactions (rages, outbursts), and may have other associated symptoms (problems with sleep or concentration, restlessness, talkativeness). Because of the mood symptoms, these youth may have difficulties with relationships. The goal of the study is to improve mood and relationships through interpersonal psychotherapy.

Participating teens will receive a free comprehensive evaluation and may earn up to $135 in gift cards. Parents may earn up to $135 for participation.

For more information or to enroll, please call 410-550-9014.

PI: Leslie Miller, M.D.