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Heng Zhu, Ph.D.

Heng Zhu, Ph.D. Heng Zhu, Ph.D.

Key Publications

HOT PAPER!  Hu S, Wan J, Su Y, Song Q, Zeng Y, Nguyen HN, Shin J, Cox E, Rho HS, Woodard C, Xia S, Liu S, Lyu H, Ming GL, Wade H, Song H, Qian J, Zhu H. (2013). DNA methylation presents distinct binding sites for human transcription factors. Elife 2013;2:e00726.  PubMed Link

Hu S, Feng Y, Henson B, Wang B, Huang X, Li M, Desai P, Zhu H. (2013). VirD: a virion display array for profiling functional membrane proteins. Anal Chem. 85(17):8046-8054.  PubMed Link

Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J. (2013). Construction of human activity-based phosphorylation networks. Mol Syst Biol. 9:655.  PubMed Link

Hu CJ, Song G, Huang W, Liu GZ, Deng CW, Zeng HP, Wang L, Zhang FC, Zhang X, Jeong JS, Blackshaw S, Jiang LZ, Zhu H, Wu L, Li YZ. (2012). Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays. Mol Cell Proteomics. 11(9):669-680.  PubMed Link

Jeong JS, Jiang L, Albino E, Marrero J, Rho HS, Hu J, Hu S, Vera C, Bayron-Poueymiroy D, Rivera-Pacheco ZA, Ramos L, Torres-Castro C, Qian J, Bonaventura J, Boeke JD, Yap WY, Pino I, Eichinger DJ, Zhu H, Blackshaw S. (2012). Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics. 11(6):O111.016253.  PubMed Link

Xie Z, Hu S, Qian J, Blackshaw S, Zhu H. (2011). Systematic characterization of protein-DNA interactions. Cell Mol Life Sci. 68(10):1657-1668.  PubMed Link

Xie Z, Hu S, Blackshaw S, Zhu H, Qian J. (2010). hPDI: a database of experimental human protein-DNA interactions. Bioinformatics. 26(2):287-289.  PubMed Link

Hu S, Xie Z, Onishi A, Yu X, Jiang L, Lin J, Rho HS, Woodard C, Wang H, Jeong JS, Long S, He X, Wade H, Blackshaw S, Qian J, Zhu H. (2009). Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell. 139(3):610-622.  PubMed Link  

HOT PAPER!  Lin Y-Y, Lu J-Y, Zhang J, Walter W, Dang W, Wan J, Tao S-C, Qian J, Zhao Y, Boeke JD, Berger SL, Zhu H. (2009). Protein acetylation microarray reveals NuA4 controls key metabolic target regulating gluconeogenesis. Cell. 136, 1073-1084.  PubMed Link

Chen C-S, Korobkova E, Chen H, Zhu J, Jian X, Tao S-C, He H and Zhu H. (2008). A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli. Nature Methods. 5, 69-74.  PubMed Link

Evans-Nguyen KM, Tao SC, Zhu H and Cotter RJ. (2008). Protein arrays on patterned porous gold substrates interrogated with mass spectrometry: detection of peptides in plasma. Anal Chem. 80, 1448-1458.  PubMed Link

Lu J-Y, Lin Y-Y, Tao S-C, Zhu J, Pickart CM, Qian J and Zhu H. (2008). Functional dissection of a HECT ubiquitin E3 ligase. Mol Cell Proteomics. 7, 35-45.  PubMed Link

Tao SC, Li Y, Zhou J, Qian J, Schnaar RL, Zhang Y, Goldstein IJ, Zhu H and Schneck JP. (2008). Lectin microarrays identify cell-specific and functionally significant cell surface glycan markers. Glycobiology. Jul 17. [Epub ahead of print].  PubMed Link

Hu S, Li Y, Liu G, Song Q, Wang L, Han Y, Zhang Y, Song Y, Yao X, Tao Y, Zeng H, Wang J, Zhu H, Chen Z-N and Wu L. (2007). A protein chip approach for high-throughput antigen identification and characterization. Proteomics. 7, 2151-61.  PubMed Link

Tao SC, Chen CS and Zhu H. (2007). Applications of protein microarray technology. Comb Chem High Throughput Screen. 10, 706-718.  PubMed Link

Zhu J, Gopinath K, Murali A, Yi G, Hayward SD, Zhu H and Kao C. (2007). RNA-binding proteins that inhibit RNA virus infection. Proc Natl Acad Sci U S A. 104, 3129-3134.  PubMed Link

Tao S-C and Zhu H. (2006). Protein chip fabrication by capture of nascent polypeptides. Nature Biotechnology. 24, 1253-1254.  PubMed Link

Zhu H, Hu S, Jona G, Zhu X, Kreiswirth N, Willey BM, Mazzulli T, Liu G, Song Q, Chen P, Cameron M, Tyler A, Wang J, Wen J, Chen W, Compton S and Snyder M. (2006). Severe acute respiratory syndrome diagnostics using a coronavirus protein microarray. Proc Natl Acad Sci U S A. 103, 4011-4016.  PubMed Link

Chen CS and Zhu H. (2006). Protein microarrays. Biotechniques. 40, 423-429. NO PMID.

Ptacek J, Devgan G, Michaud G, Zhu H, Zhu X, et al. (2005). Global analysis of protein phosphorylation in yeast. Nature. 438, 679-684.  PubMed Link

Huang J, Zhu H, Haggarty SJ, Spring DR, Hwang H, Jin F, Snyder M, Schreiber SL. (2004). Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc Natl Acad Sci U S A. 101, 16594-16599.  PubMed Link

Hall DA, Zhu H, Zhu X, Royce T, Gerstein M, Snyder M. (2004). Regulation of gene expression by a metabolic enzyme. Science. 306, 482-484.  PubMed Link

Kafadar KA, Zhu H, Snyder M, Cyert MS. (2003). Negative regulation of calcineurin signaling by Hrr25p, a yeast homolog of casein kinase I. Genes Dev. 17, 2698-2708.  PubMed Link

Zhu H, Bilgin M, Bangham R, Hall D, Casamayor A, Bertone P, Lan N, Jansen R, Bidlingmaier S, Houfek T, Mitchell T, Miller P, Dean RA, Gerstein M, Snyder M. (2001). Global analysis of protein activities using proteome chips. Science. 293, 2101-2105.  PubMed Link

Zhu H, Klemic JF, Chang S, Bertone P, Casamayor A, Klemic KG, Smith D, Gerstein M, Reed MA, Snyder M. (2000). Analysis of yeast protein kinases using protein chips. Nat. Genet. 26, 283-289.  PubMed Link

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