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Robert E. Cohen, Ph.D.

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Key Publications

Cooper EM, Boeke JD, Cohen RE. (2010). Specificity of the BRISC deubiquitinating enzyme is not due to selective binding to Lys63-linked polyubiquitin. J Biol Chem. 285, 10344-10352.  PubMed Link

Sims JJ and Cohen RE. (2009). Linkage-specific avidity defines the lysine 63-linked polyubiquitin binding preference of Rap80. Molec. Cell.33, 775-783PubMed Link

Wang T, Yin L, Cooper EM, Lai MY, Dickey S, Pickart CM, Fushman D, Wilkinson KD, Cohen RE*, Wolberger C.* (2009). Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of Otubain 1. J. Molec. Biol. 386, 1011-1023.  *Co-corresponding authors.  PubMed Link

Cooper EM, Cutcliffe C, Kristiansen TZ, Pandey A, Pickart CM, Cohen RE. (2009). K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated BRCC36 and proteasomal POH1. EMBO Journal. 28, 621-631.  PubMed Link

Yao T, Song L, Jin J, Cai Y, Takahashi H, Swanson SK, Washburn MP, Florens L, Conaway RC, Cohen RE, Conaway JW. (2008). Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin remodeling complex.  Molecular Cell. 31, 909–917.  PubMed Link

Winborn BJ, Travis SM, Todi SV, Scaglione KM, Xu P, Williams AJ, Cohen RE, Peng J, Paulson HL. (2008). The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J Biol Chem. 283, 26436-26443.  PubMed Link

Yao T, Song L, Xu W, DeMartino GN, Florens L, Swanson SK, Washburn MP, Conaway RC, Conaway JW, Cohen RE. (2006). Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol. 8, 994-1002.  PubMed Link

Yao T, Cohen RE. (2005). Ubiquitin-ovomucoid fusion proteins as model substrates for monitoring degradation and deubiquitination by proteasomes. Methods Enzymol. 398, 522-540.  PubMed Link

Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y. (2005). Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J. 24, 3747-3756.  PubMed Link

Pickart CM, Cohen RE. (2004). Proteasomes and their kin: proteases in the machine age. Nat Rev Mol Cell Biol. 5, 177-187.  PubMed Link

Yao T, Cohen RE. (2002). A cryptic protease couples deubiquitination and degradation by the proteasome. Nature. 419, 403-407.  PubMed Link

Hu M, Li P, Li M, Li W, Yao T, Wu JW, Gu W, Cohen RE, Shi Y. (2002). Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell. 111, 1041-1054.  PubMed Link