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Journalists are invited to hear from several Johns Hopkins-affiliated startups as Digital Health Day continues with Mid-Atlantic University Technology Day.
Protein chemists at Johns Hopkins report they are closer to explaining why certain blood cancers are able to crack a molecular security system and run rampant.
In a small clinical study with an anticancer drug that halts blood vessel growth, a handful of people with neurofibromatosis type 2 (NF2) and hearing loss had restoration of hearing. Results of the collaborative study by researchers at Johns Hopkins Medicine, the National Institutes of Health and Massachusetts General Hospital were described online March 14 in the Journal of Clinical Oncology.
Physicians and biomedical engineers from Johns Hopkins report what they believe is the first successful effort to wiggle fingers individually and independently of each other using a mind-controlled artificial “arm” to control the movement.
While working to improve a tool that measures the pushes and pulls sensed by proteins in living cells, biophysicists discovered one reason spiders’ silk is so elastic: Pieces of the silk’s protein threads act like supersprings, stretching to five times their initial length. The investigators say the tool will shed light on many biological events, including the shifting forces between cells during cancer metastasis.
Taking a high dose of vitamin D3 is safe for people with multiple sclerosis and may help regulate the body’s hyperactive immune response, according to a pilot study published by Johns Hopkins physicians in the Dec. 30 online issue of Neurology, the medical journal of the American Academy of Neurology.
Using information gleaned from more than 20,000 men, researchers at Johns Hopkins have affirmed the value of their alternative system for assessing the likelihood of growth and spread of prostate cancer. The new grading system, they say, is not only easier to use and understand, but also more accurate than the long-used Gleason grading system, and it has the potential to substantially reduce overtreatment of low-risk tumors.
Although the vast majority of pediatric spine surgeries are safe, a handful of neuromuscular conditions seem to fuel the risk of cardiac arrest during such operations, according to research led by investigators at the Johns Hopkins Children’s Center.
A major source of American health information data contains a handful of glaring flaws related to health risks, say Johns Hopkins researchers in a study published online Wednesday in the journal PLOS ONE.
The Johns Hopkins University and Microsoft have announced plans to work together to redesign the way medical devices in an intensive care unit (ICU) talk to each other.
Today, Johns Hopkins researchers introduced EpiWatch, designed to use Apple Watch to collect patient data through the open source ResearchKit framework designed by Apple. The app, which runs on Apple Watch and iPhone, collects data from patients with epilepsy before, during and after their seizures.
A study led by Johns Hopkins researchers has linked the immunosuppressive drug mycophenolate mofetil (MMF) to an increased risk of central nervous system (CNS) lymphoma in solid organ transplant patients. But the same study also found that another class of immunosuppressive drugs, called calcineurin inhibitors (CNIs), given alone or in combination with MMF, appears to protect transplant patients against this rare form of lymphoma.
Disease gene hunters usually focus on the regions of the genome known as exons, which form the genetic blueprints of proteins. In recent decades, it’s become clear that the DNA letters located between genes play a critical regulatory role, determining whether proteins get made. But exons retain their starring role in disease research. Now, however, as Sumantra Chatterjee, Ph.D., reports Oct. 7 at the annual meeting of the American Society of Human Genetics in Baltimore, newly found genetic contributors to Hirschsprung’s disease suggest that increased research on noncoding DNA could help complete the map of genetic causes of many complex diseases.
Human Tumor "Avatars" Reveal New Genetic Sources of Drug Response in Late-Stage Colorectal Cancer ...
Using pieces of human tumors grafted into mice, a team led by Johns Hopkins Kimmel Cancer Center researchers and their colleagues from the University of Torino has identified new mutations in six genes related to drug resistance and sensitivity in late-stage colorectal cancer.
Working with tissue, blood and DNA from six people with precancerous and cancerous lung lesions, a team of Johns Hopkins scientists has identified what it believes are among the very earliest “premalignant” genetic changes that mark the potential onset of the most common and deadliest form of disease.
Using data from their detailed analysis of senior medical services offered by nearly 5,000 U.S. hospitals before the 2009 passage of the Affordable Care Act (ACA), researchers led by a Johns Hopkins geriatrician say they have developed a Senior Care Services Scale (SCSS) that suggests a serious “mismatch” between what’s offered and what older adult populations need.
Researchers at the Johns Hopkins University School of Medicine, along with colleagues at Emory University and Cedars-Sinai, have published in the journal Gastroenterology the first major, in-depth analysis of genetic risk factors of inflammatory bowel disease in African-Americans
Scientists at Johns Hopkins report they have deciphered the structure and unusual shape of a bacterial protein that prepares segments of DNA for the insertion of so-called jumping genes. The clamshell shape, they say, has never before been seen in a protein but connects nicely with its function: that of bending a segment of DNA into a 180-degree U-turn.
Results of a trio of studies done on human cancer tissue biopsies have added to growing evidence that a so-called jumping gene called LINE-1 is active during the development of many gastrointestinal cancers. The Johns Hopkins scientists who conducted the studies caution there is no proof that the numerous new “insertions” of these rogue genetic elements in the human genome actually cause cancers, but they say their experiments do suggest that these elements, formally known as transposons, might one day serve as a marker for early cancer diagnosis.
Research Advances Potential for a Globally Accurate Diagnostic Test and Vaccine for Genital and Oral ...
Findings from a pair of new studies could speed up the development of a universally accurate diagnostic test for human herpes simplex viruses (HSV), according to researchers at Johns Hopkins and Harvard universities and the National Institutes of Health (NIH). The work may also lead to the development of a vaccine that protects against the virus.
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