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Research
The Division of Immunogenetics and Transplantation Immunology is engaged in research in a variety of areas including regulation of the immune response in both solid organ and hematopoetic stem cell transplantation, varying immunogenicity of HLA antigens, immune monitoring, identification of non-HLA targets in allogeneic transplantation, the role of non-HLA antibodies in allogeneic transplantation, isolation and characterization of HLA-specific B cells, disease associations and pharmacogenetics. The division is also involved in the development and improvement of various technologies to assess allosensitization.
Ongoing Studies
- Frequency and strength of the humoral response to HLA antigens
- Evaluation of the humoral response in composite tissue allografts
- Impact of red blood cell transfusion on allosensitization
- Impact of non-HLA antibodies on transplanted allografts
- Impact of desensitization treatment on HLA and AT1R antibody
- Role of AT1R antibodies in other disease processes
- Detection, quantification and isolation of HLA-specific B cells
- Impact of HLA mismatches in HLA-haploidentical hematopoietic stem cell transplantation
- Effect of KIR gene and ligand incompatibility in hematopoietic stem cell transplantation
- Genomic loss of mismatched HLA haplotypes in recipients of haploidentical hematopoietic stem cell transplantation
- Role of HLA in drug sensitivity
- Variable effect of bortezomib on HLA antibodies
- Improvement of HLA antibody testing methods
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