In This Section      


lab technician

The Division of Immunogenetics and Transplantation Immunology is engaged in research in a variety of areas including regulation of the immune response in both solid organ and hematopoetic stem cell transplantation, varying immunogenicity of HLA antigens, immune monitoring, identification of non-HLA targets in allogeneic transplantation, the role of non-HLA antibodies in allogeneic transplantation, isolation and characterization of HLA-specific B cells, disease associations and pharmacogenetics. The division is also involved in the development and improvement of various technologies to assess allosensitization.

Ongoing Studies

  • Frequency and strength of the humoral response to HLA antigens
  • Evaluation of the humoral response in composite tissue allografts
  • Impact of red blood cell transfusion on allosensitization
  • Impact of non-HLA antibodies on transplanted allografts
  • Impact of desensitization treatment on HLA and AT1R antibody
  • Role of AT1R antibodies in other disease processes
  • Detection, quantification and isolation of HLA-specific B cells
  • Impact of HLA mismatches in HLA-haploidentical hematopoietic stem cell transplantation
  • Effect of KIR gene and ligand incompatibility in hematopoietic stem cell transplantation
  • Genomic loss of mismatched HLA haplotypes in recipients of haploidentical hematopoietic stem cell transplantation
  • Role of HLA in drug sensitivity
  • Variable effect of bortezomib on HLA antibodies
  • Improvement of HLA antibody testing methods