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School of Medicine
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Mary S. Leffell, Ph.D., Diplomate, ABMLI, ABHI
Professor of Medicine, Emeritus
Mary S. (Sue) Leffell is a Professor of Medicine Emeritus and the former Director of the Immunogenetics and Transplantation Immunology Division. She has been an active participant in clinical histocompatibility and transplantation for over thirty-eight years. Her research interests have included population studies of the distribution of HLA alleles and haplotypes, minor histocompatibility antigens, KIR, and cytokine alleles among various racial/ethnic groups. In transplantation immunology, she helped define the effect of proinflammatory events and infection on the breadth and strength of HLA-specific antibodies among solid organ transplant candidates and determined the incidence of post-transplant sensitization following mismatched allogeneic hematopoietic cell transplantation (HCT). She was instrumental in development of a protocol for desensitization and subsequent successful engraftment of HCT candidates with donor HLA-specific antibodies. She is a past president of the American Society for Histocompatibility and Immunogenetics (ASHI) and served two terms on the Board of Directors for the national OPTN/UNOS. She was the first nationally elected Chair of the OPTN/UNOS Histocompatibility Committee. She was one of the founders and a member of the program faculty for the Histocompatibility Specialist Course of the American Foundation for Donation and Transplantation for over thirty years. From 2005-2009 she was a member of the Advisory Committee on Organ Transplantation to the Secretary of the Department of Health and Human Services. She is currently a member of the International Histocompatibility and Immunogenetics Council and has been honored with both the Distinguished Scientist Award and a Distinguished Service Award from the ASHI. Since retiring from the Johns Hopkins University School of Medicine, she has stayed active in the field through collaboration with other faculty on research projects and manuscripts as well as consulting on certain issues in transplantation.
Dr. Leffell's publications: PubMed database