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Institutional Review Entity (DURC)
Agents and Toxins
Work with one or more of the following fifteen (15) agents and/or toxins listed in the US Government DURC Policy may constitute DURC and must be evaluated by the IRE. (Note that all agents and toxins listed below also are controlled by the US Government as Select Agents, see HSE505 for details):
- Avian influenza virus (highly pathogenic)
- Bacillus anthracis
- Botulinum neurotoxins (any quantity and includes Botox)
- Burkholderia mallei
- Burkholderia pseudomallei
- Ebola virus
- Foot-and-mouth disease virus
- Francisella tularensis
- Marburg virus
- Reconstructed 1918 influenza virus
- Rinderpest virus
- Toxin-producing strains of Clostridium botulinum
- Variola major virus
- Variola minor virus
- Yersinia pestis
Categories of Experiments
The following seven (7) categories of experiments are evaluated, in conjunction with the use of one of the fifteen (15) agents or toxins above to assess the dual use potential of a research project:
- Enhances the harmful consequences of the agent or toxin.
- Disrupts the immunity or the effectiveness of an immunization against the agent or toxin without clinical and/or agricultural justification.
- Confers to the agent or toxin resistance to clinically and/or agriculturally useful prophylactic or therapeutic interventions against that agent or toxin or facilitates their ability to evade detection methodologies.
- Increases the stability, transmissibility, or the ability to disseminate the agent or toxin.
- Alters the host range or tropism of the agent or toxin.
- Enhances the susceptibility of a host population to the agent or toxin.
- Generates or reconstitutes an eradicated or extinct agent or toxin listed above.