Clostridium difficile (C. difficile)

At the Johns Hopkins Hospital, we perform surveillance for healthcare-associated transmission of C. difficile on all hospital units. Healthcare-associated transmission of C. difficile is defined as a positive test for the organism in the setting of diarrheal disease and a clinical picture consistent with C. difficile disease >48 hours after hospital admission if the condition did not appear to be present upon hospital or unit admission.  C. difficile healthcare-associated transmission rates are expressed as the number of C. difficile transmissions per 10,000 patient days.  Our C. difficile transmission prevention program includes hand hygiene promotion, antimicrobial stewardship, isolation precautions, environmental cleaning and disinfection, and programs to promote, monitor and sustain evidence-based best practices for MDRO prevention. 

Tools and Resources

• JHH Hand Hygiene Policy
• JHH Isolation Policy
• HICPAC Management of Multidrug-Resistant Organisms in Healthcare Settings, 2006
• SHEA-IDSA Compendium of Strategies to Prevent Clostridium difficile Infections in Acute Care Hospitals
• HICPAC Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings

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