In This Section      

Behavioral Cardiology

Contact Information:

Roy C. Ziegelstein, M.D. (

Laboratory Location:

The Johns Hopkins Bayview Medical Center

Research Focus:

Our research group focuses on behavioral cardiology, i.e., on the relationship between psychological distress and cardiovascular disease.  The group consists of individuals from several divisions and departments at Johns Hopkins (particularly cardiology and psychiatry) and we also collaborate with individuals at other institutions. 

Funding Support:

NIH Center for Mind-Body Research Grant

Active Projects:

Among the projects our group is currently involved in are natural history studies of the relationship between depression and/or anxiety and post-myocardial infarction prognosis; studies of patients with implantable defibrillators; studies of platelet activation in patients with acute coronary syndromes and depression; and studies on the impact of altered sleep on heart rate variability.

Laboratory Collaborators:

  • Gina Magyar-Russell, PhD, Department of Psychiatry, Johns Hopkins
  • James Fauerbach, PhD, Department of Psychiatry, Johns Hopkins
  • David Bush, MD, Division of Cardiology, Johns Hopkins
  • Constantine Lyketsos, MD, Department of Psychiatry, Johns Hopkins
  • Una McCann, MD, Department of Psychiatry, Johns Hopkins
  • Kapil Parakh, MD, MPH, Department of Medicine, Johns Hopkins

Selected Bibliography:

1. Thombs BD, Bass EB, Ford DE, Stewart KJ, Tsilidis KK, Patel U, Fauerbach JA, Bush DE, Ziegelstein RC.  Prevalence of depression in survivors of acute myocardial infarction. J Gen Intern Med 2006; 21:30-8.
2. Ziegelstein RC, Thombs BD. The brain and the heart: the twain meet. Eur Heart J 2005; 26:2607-8.
3. Fauerbach JA, Bush DE, Thombs BD, McCann UD, Fogel J, Ziegelstein RC. Depression following acute myocardial infarction: a prospective relationship with ongoing health and function. Psychosomatics 2005; 46:355-61.
4. Bush DE, Ziegelstein RC, Patel UV, Thombs BD, Ford DE, Fauerbach JA, McCann UD, Stewart KJ, Tsilidis KK, Patel AL, Feuerstein CJ, Bass EB. Post-myocardial infarction depression. Evid Rep Technol Assess (Summ) 2005;123:1-8.
5. Ziegelstein RC, Kim SY, Kao D, Fauerbach JA, Thombs BD, McCann U, Colburn J, Bush DE. Can doctors and nurses recognize depression in patients hospitalized with an acute myocardial infarction in the absence of formal screening? Psychosom Med 2005; 67:393-7. 
6. Fogel J, Fauerbach JA, Ziegelstein RC, Bush DE. Quality of life in physical health domains predicts adherence among myocardial infarction patients even after adjusting for depressive symptoms.
J Psychosom Res 2004; 56:75-82. 
7. Romanelli J, Fauerbach JA, Bush DE, Ziegelstein RC. The significance of depression in older patients after myocardial infarction.  J Am Geriatr Soc 2002; 50:817-22.
8. Ziegelstein RC. Depression in patients recovering from a myocardial infarction. JAMA 2001; 286:1621-7.
9. Bush DE, Ziegelstein RC, Tayback M, Richter D, Stevens S, Zahalsky H, Fauerbach JA.  Even minimal symptoms of depression increase mortality risk after acute myocardial infarction. Am J Cardiol 2001; 88:337-41.
10. Ziegelstein RC, Fauerbach JA, Stevens SS, Romanelli J, Richter DP, Bush DE. Patients with depression are less likely to follow recommendations to reduce cardiac risk during recovery from a myocardial infarction. Arch Intern Med 2000;160:1818-23.