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Weiss Lab

Dr. Robert Weiss directs a multi-disciplinary team at Johns Hopkins as well as collaborators at Cedars Sinai Medical Center in Los Angeles dedicated to identifying the most important clinical, genetic, structural, contractile and metabolic causes of sudden cardiac death as well as the means to reverse the underlying pathology and lower risk.

Contact Information:

Robert G. Weiss, MD      

Research Focus:

Energetic Consequences and Causes of Heart Failure -Predictors of Sudden Cardiac Death -Non-Invasive Magnetic Resonance -Role of Creatine Kinase in Heart Failure -Spectroscopy and Imaging -Coronary Endothelial Function -Small animal cardiovascular imaging

Funding Support:

NIH/HLBI D.W. Reynolds Foundation      

Active Projects:

1. Role of altered energy metabolism in exercise intolerance and fatigue in patients with heart failure
2. Mitochondrial creatine kinase in myocardial remodeling and heart failure
3. Mechanistic role of inflammation in patients with coronary atherosclerosis 
4. Inflammatory contribution to accelerated atherosclerosis in HIV+ people
5. Skeletal muscle contribution to fatigability in the elderly

Collaborators

Selected Bibliography

  • Weiss K, Schar M, Panjrath GS, Zhang Y, Sharma K, Bottomley PA, Golozar A, Steinberg A, Gerstenblith G, Russell SD, Weiss RG: Fatigability, exercise intolerance, and abnormal skeletal muscle energetics in heart failure. Circulation Heart Failure (in press) 2017.
  • Iantorno M, Schär M, Soleimanifard S, Brown T, Moore R, Barditch-Crovo P, Stuber M, Lai S, Gerstenblith G, Weiss RG, Hays AG. Coronary artery endothelial dysfunction is present in HIV positive individuals without significant coronary artery disease. AIDS 2017 (in press).
  • Iantorno M, Hays A, Schär M, Krishnasswamy R, Solemanifard S, Steinberg AM, Stuber M, Gerstenblith G, Weiss RG: Simultaneous non-invasive assessment of systemic and coronary endothelial function. Circulation, Cardiovascular Imaging.  2016: 9(3):e003954
  • Hays AG, Iantorno M, Soleimanifard S, Steinberg A, Schär M, Gerstenblith G, Stuber M, Weiss RG, Coronary vasomotor responses to isometric handgrip exercise are primarily mediated by nitric oxide: a noninvasive MRI test of coronary endothelial function, Am J Physiol Heart Circ Physiol. 2015 Mar 27:ajpheart.00023.2015.   doi:10.1152/ajpheart.00023.2015.
  • Bottomley, PA, Gurusher SP, Sheghan, L, Hirsch GA, Wu K, Najjar SS, Steinberg A, 
  • Gerstenblith G, Weiss RG. Metabolic Rates of ATP Transfer Through Creatine Kinase (CK FLUX) Predict Clinical Heart Failure Events and Death. Science Translational Medicine 2013; 5: 215re3
  • Gupta A, Akki A, Wang Y, Leppo ML, Chacko VP, Foster DB, Caceres V, Shi S, Kirk JA, Su J, Lai S, Paolocci N, Steenbergen C, Gerstenblith G, Weiss RG: Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved.   The Journal of Clinical Investigation.  2012;122:291-302.
  • Wu KC, Gerstenblith G, Guallar E, Marine JE, Dalal D, Cheng A, Marban E, Lima JA, Tomaselli GF, Weiss RG: Combined cardiac MRI and C-reactive protein levels identify a cohort at low risk for defibrillator firings and death.  Circulation Cardiovascular Imaging 2012;5:178-186.
  • Hays AG,  Hirsch GA, Kelle S, Gerstenblith G, Weiss RG, Stuber M:  Non-Invasive visualization of coronary artery endothelial function in healthy subjects and patients with coronary artery disease.  Journal of American College of Cardiology.  2010;56:1657-65. 
  • Wu KC, Weiss RG, Thiemann DR, Kitagawa K, Schmidt A, Dalal D, Lai S, Bluemke DA, Gerstenblith G, Marban E, Tomaselli GF, Lima JAC, Late Gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy.  Journal of American College of Cardiology 2008; 51:2414-2421.
  • Weiss RG, Gerstenblith G, Bottomley PA: ATP Flux through creatine kinase in the normal, stressed, and failing human heart.  Proceedings of the National Academy of Science 2005: 1002:808-813