In This Section      

Hwang Lab

Principal Investigator:  Chao-Wei Hwang, MDPeter Johnston, MD,

Development and optimization of stem cell and regenerative therapies for heart failure and myocardial infarction.


Active Projects


  • Development of implantable bioreactors for paracrine factor production.
  • Operations research modeling of clinical decisions in interventional cardiology.
  • TWILIGHT Trial 
  • PARADISE-MI Trial 


  • Hwang CW, Levin AD, Jonas M, Li PH, Edelman ER.  Thrombosis modulates arterial drug distribution for drug-eluting stents.  Circulation.  2005 Apr 5; 111(13): 1619-1626.
  • Levin AD, Jonas M, Hwang CW, Edelman ER.  Local and systemic drug competition in drug-eluting stent tissue deposition properties.  J Control Release.  2005 Dec 5; 109(1-3):236-43.
  • Hwang CW and Edelman ER.  “Principles of continuum pharmacokinetics in stent-based drug elution,” in Handbook of Drug-Eluting Stents, Serruys PW and Gershlick AH, eds.  London, United Kingdom: Taylor & Francis Press, 2005: 47-56. 
  • Blumenthal RS, Hwang CW, Nasir K.  Selective use of coronary artery calcium screening: Worth the cost?  J Am Coll Cardiol.  2009 Sep 29; 54(14): 1268-1270.
  •  Le KN, Hwang CW, Tzafriri AR, Lovich MA, Hayward A, Edelman ER.  Vascular regeneration by local growth factor release is self-limited by microvascular clearance.  Circulation. 2009 Jun 9; 119(22): 2928-2935.
  • Hwang CW, Johnston PV, Gerstenblith G, Weiss RG, Tomaselli GF, Bogdan VE, Panigrahi A, Leszczynska A, Xia Z.  Stem cell impregnated nanofiber stent sleeve for on-stent production and intravascular delivery of paracrine factors.  Biomaterials.  2015 Jun; 52: 318-326.
  • Galiatsatos P, Win TT, Monti J, Johnston PV, Herzog W, Trost J, Hwang CW, Fridman GY, Wang NY, Silber HA.  A noninvasive hand-held device identifies elevated left ventricular filling pressure using finger photoplethysmography during the Valsalva maneuver.  Am J Cardiol.  2017 Apr 1.  119(7): 1053-1060.
  • Czarny MJ, Hwang CW, Naiman DQ, Lemmon CC, Hasan RK, Wang T, Aversano T. Heparin Versus Bivalirudin for Elective Percutaneous Coronary Intervention in a Community Cohort.  Catheter Cardiovasc Interv.  2017 Sep 1.  90(3): 366-377.

1.    US Patent 8,696,740:  Implantable pressure-actuated drug delivery systems and methods of manufacture and use.  Johns Hopkins University Applied Physics Laboratory.  Issued April 15, 2014.
2.    US Patent 9,504,586: Methods of Manufacture and Use of Implantable Pressure-Actuated Drug Delivery Systems.  Johns Hopkins University Applied Physics Laboratory.  Issued November 29, 2016.

Johnston-Hwang Lab Collaborators